BRD-K36354764_-666_HA1E_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

103 genes differentially expressed following the BRD-K36354764_-666_HA1E_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF4 activating transcription factor 4
BAG3 BCL2-associated athanogene 3
CBS cystathionine-beta-synthase
CCND2 cyclin D2
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHIC2 cysteine-rich hydrophobic domain 2
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
G6PD glucose-6-phosphate dehydrogenase
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GCLM glutamate-cysteine ligase, modifier subunit
GULP1 GULP, engulfment adaptor PTB domain containing 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HK2 hexokinase 2
HMOX1 heme oxygenase 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
KLK5 kallikrein-related peptidase 5
LDOC1 leucine zipper, down-regulated in cancer 1
MBOAT7 membrane bound O-acyltransferase domain containing 7
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MLPH melanophilin
MT1F metallothionein 1F
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
NELL2 NEL-like 2 (chicken)
NRCAM neuronal cell adhesion molecule
NUPR1 nuclear protein, transcriptional regulator, 1
OSBPL10 oxysterol binding protein-like 10
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PEA15 phosphoprotein enriched in astrocytes 15
PELI1 pellino E3 ubiquitin protein ligase 1
PHGDH phosphoglycerate dehydrogenase
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PNKP polynucleotide kinase 3'-phosphatase
PPARD peroxisome proliferator-activated receptor delta
SCG5 secretogranin V
SCGB2A1 secretoglobin, family 2A, member 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC38A1 solute carrier family 38, member 1
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SLCO4A1 solute carrier organic anion transporter family, member 4A1
SPINT2 serine peptidase inhibitor, Kunitz type, 2
STC2 stanniocalcin 2
STX1A syntaxin 1A (brain)
TNNT1 troponin T type 1 (skeletal, slow)
TPD52L1 tumor protein D52-like 1
TXNRD1 thioredoxin reductase 1
VEGFA vascular endothelial growth factor A
WARS tryptophanyl-tRNA synthetase
XBP1 X-box binding protein 1
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
AKAP12 A kinase (PRKA) anchor protein 12
ANXA6 annexin A6
CCND1 cyclin D1
CCNE2 cyclin E2
CD59 CD59 molecule, complement regulatory protein
CDC20 cell division cycle 20
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CXCL8 chemokine (C-X-C motif) ligand 8
CYTH1 cytohesin 1
CYTL1 cytokine-like 1
DHRS2 dehydrogenase/reductase (SDR family) member 2
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FABP7 fatty acid binding protein 7, brain
GTPBP8 GTP-binding protein 8 (putative)
HES1 hes family bHLH transcription factor 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HN1 hematological and neurological expressed 1
HOXA10 homeobox A10
HOXA5 homeobox A5
HOXC6 homeobox C6
ISG15 ISG15 ubiquitin-like modifier
KRT13 keratin 13, type I
KRT4 keratin 4, type II
LYPLA1 lysophospholipase I
MARCKS myristoylated alanine-rich protein kinase C substrate
MATN2 matrilin 2
MGP matrix Gla protein
MSH6 mutS homolog 6
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
PDE4B phosphodiesterase 4B, cAMP-specific
PFKL phosphofructokinase, liver
RRAGD Ras-related GTP binding D
S100A8 S100 calcium binding protein A8
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TNS1 tensin 1
USP22 ubiquitin specific peptidase 22