BRD-K36198571_-666_HT29_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

126 genes differentially expressed following the BRD-K36198571_-666_HT29_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ADIRF adipogenesis regulatory factor
ADM adrenomedullin
ALDOC aldolase C, fructose-bisphosphate
ASPN asporin
BMP2 bone morphogenetic protein 2
BTG3 BTG family, member 3
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
COL10A1 collagen, type X, alpha 1
COL11A1 collagen, type XI, alpha 1
COMP cartilage oligomeric matrix protein
CPB1 carboxypeptidase B1 (tissue)
CPM carboxypeptidase M
CSRP2 cysteine and glycine-rich protein 2
CTSK cathepsin K
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL11 chemokine (C-X-C motif) ligand 11
CYB5R2 cytochrome b5 reductase 2
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DCN decorin
DDIT4 DNA-damage-inducible transcript 4
DHCR7 7-dehydrocholesterol reductase
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DPYSL2 dihydropyrimidinase-like 2
DUSP6 dual specificity phosphatase 6
EGLN3 egl-9 family hypoxia-inducible factor 3
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
FADS1 fatty acid desaturase 1
FAM129A family with sequence similarity 129, member A
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FOSL1 FOS-like antigen 1
FSCN1 fascin actin-bundling protein 1
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GAS6 growth arrest-specific 6
GLRX glutaredoxin (thioltransferase)
GPM6B glycoprotein M6B
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H2BG histone cluster 1, H2bg
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA2 heat shock 70kDa protein 2
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
IDI1 isopentenyl-diphosphate delta isomerase 1
IFI27 interferon, alpha-inducible protein 27
IL1R2 interleukin 1 receptor, type II
IL32 interleukin 32
INSIG1 insulin induced gene 1
IRF7 interferon regulatory factor 7
ISG20 interferon stimulated exonuclease gene 20kDa
JAG1 jagged 1
KCNK1 potassium channel, two pore domain subfamily K, member 1
KDM3A lysine (K)-specific demethylase 3A
KRT14 keratin 14, type I
LARP6 La ribonucleoprotein domain family, member 6
LDLR low density lipoprotein receptor
MAN1A1 mannosidase, alpha, class 1A, member 1
MAP7 microtubule-associated protein 7
MSMO1 methylsterol monooxygenase 1
MX1 MX dynamin-like GTPase 1
NCF2 neutrophil cytosolic factor 2
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NLRP2 NLR family, pyrin domain containing 2
NR4A1 nuclear receptor subfamily 4, group A, member 1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NUCB2 nucleobindin 2
PDGFRL platelet-derived growth factor receptor-like
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PGK1 phosphoglycerate kinase 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PMP22 peripheral myelin protein 22
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRELP proline/arginine-rich end leucine-rich repeat protein
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SDC4 syndecan 4
SEC24D SEC24 family member D
SFN stratifin
SFRP4 secreted frizzled-related protein 4
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC43A3 solute carrier family 43, member 3
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SOCS2 suppressor of cytokine signaling 2
SOX9 SRY (sex determining region Y)-box 9
SQLE squalene epoxidase
TCF4 transcription factor 4
THBS2 thrombospondin 2
TIMP3 TIMP metallopeptidase inhibitor 3
TRD T cell receptor delta locus
TXNIP thioredoxin interacting protein
VEGFA vascular endothelial growth factor A
WISP2 WNT1 inducible signaling pathway protein 2

decreased expression

Symbol Name
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
CCNA2 cyclin A2
CCNF cyclin F
CDC25B cell division cycle 25B
CENPF centromere protein F, 350/400kDa
F12 coagulation factor XII (Hageman factor)
GATA2 GATA binding protein 2
GOLGA8A golgin A8 family, member A
HMG20B high mobility group 20B
KIF20A kinesin family member 20A
KRT7 keratin 7, type II
NRIP1 nuclear receptor interacting protein 1
OXTR oxytocin receptor
PEBP1 phosphatidylethanolamine binding protein 1
PLAC8 placenta-specific 8
PLK1 polo-like kinase 1
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
S100A11 S100 calcium binding protein A11
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPTBN1 spectrin, beta, non-erythrocytic 1
TACC3 transforming, acidic coiled-coil containing protein 3
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TNC tenascin C
TOR1A torsin family 1, member A (torsin A)
TPX2 TPX2, microtubule-associated