BRD-K36055864_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

230 genes differentially expressed following the BRD-K36055864_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ATF3 activating transcription factor 3
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
C2CD2L C2CD2-like
CA1 carbonic anhydrase I
CADM1 cell adhesion molecule 1
CCL20 chemokine (C-C motif) ligand 20
CCP110 centriolar coiled coil protein 110kDa
CD1A CD1a molecule
CD9 CD9 molecule
CDKN2AIP CDKN2A interacting protein
CHERP calcium homeostasis endoplasmic reticulum protein
CHRDL1 chordin-like 1
CLDN18 claudin 18
CLU clusterin
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL5 chemokine (C-X-C motif) ligand 5
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42
DLX2 distal-less homeobox 2
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DUSP1 dual specificity phosphatase 1
DUSP6 dual specificity phosphatase 6
EFNA1 ephrin-A1
ENC1 ectodermal-neural cortex 1 (with BTB domain)
FCN1 ficolin (collagen/fibrinogen domain containing) 1
FNDC3B fibronectin type III domain containing 3B
G0S2 G0/G1 switch 2
GUCY1B3 guanylate cyclase 1, soluble, beta 3
H2BFS H2B histone family, member S (pseudogene)
H3F3B H3 histone, family 3B (H3.3B)
HES1 hes family bHLH transcription factor 1
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2AM histone cluster 1, H2am
HIST1H2BC histone cluster 1, H2bc
HIST1H2BD histone cluster 1, H2bd
HIST1H2BE histone cluster 1, H2be
HIST1H2BF histone cluster 1, H2bf
HIST1H2BG histone cluster 1, H2bg
HIST1H2BH histone cluster 1, H2bh
HIST1H2BK histone cluster 1, H2bk
HIST1H4C histone cluster 1, H4c
HIST1H4H histone cluster 1, H4h
HIST2H2BE histone cluster 2, H2be
HLF hepatic leukemia factor
ICAM1 intercellular adhesion molecule 1
ICAM2 intercellular adhesion molecule 2
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IGKC immunoglobulin kappa constant
IGL immunoglobulin lambda locus
IL1RN interleukin 1 receptor antagonist
ISG15 ISG15 ubiquitin-like modifier
JMJD6 jumonji domain containing 6
JUN jun proto-oncogene
KLF10 Kruppel-like factor 10
KLK11 kallikrein-related peptidase 11
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
LGALS8 lectin, galactoside-binding, soluble, 8
LTF lactotransferrin
MAOA monoamine oxidase A
MMP9 matrix metallopeptidase 9
MT1X metallothionein 1X
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYH10 myosin, heavy chain 10, non-muscle
NDN necdin, melanoma antigen (MAGE) family member
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
NINJ1 ninjurin 1
NKX2-1 NK2 homeobox 1
PDGFRL platelet-derived growth factor receptor-like
PER2 period circadian clock 2
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D
PSPC1 paraspeckle component 1
PYGB phosphorylase, glycogen; brain
RAE1 ribonucleic acid export 1
REEP1 receptor accessory protein 1
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RHOB ras homolog family member B
RPS4Y1 ribosomal protein S4, Y-linked 1
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
S100A12 S100 calcium binding protein A12
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SAT1 spermidine/spermine N1-acetyltransferase 1
SCYL3 SCY1-like 3 (S. cerevisiae)
SDC4 syndecan 4
SELL selectin L
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SFTPA2 surfactant protein A2
SFTPB surfactant protein B
SFTPC surfactant protein C
SFTPD surfactant protein D
SIGLEC15 sialic acid binding Ig-like lectin 15
SLC16A6 solute carrier family 16, member 6
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa
SOX4 SRY (sex determining region Y)-box 4
SQRDL sulfide quinone reductase-like (yeast)
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STK38L serine/threonine kinase 38 like
SYNGR3 synaptogyrin 3
TERF2IP telomeric repeat binding factor 2, interacting protein
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TRIT1 tRNA isopentenyltransferase 1
TSC22D3 TSC22 domain family, member 3
TUFT1 tuftelin 1
TXNIP thioredoxin interacting protein
TXNL4B thioredoxin-like 4B
VCAN versican
ZNF451 zinc finger protein 451

decreased expression

Symbol Name
ABHD2 abhydrolase domain containing 2
ACTA2 actin, alpha 2, smooth muscle, aorta
AGTR1 angiotensin II receptor, type 1
ALAS1 5'-aminolevulinate synthase 1
ALB albumin
ANPEP alanyl (membrane) aminopeptidase
AP2M1 adaptor-related protein complex 2, mu 1 subunit
ATF5 activating transcription factor 5
AXL AXL receptor tyrosine kinase
C6ORF62 chromosome 6 open reading frame 62
C9 complement component 9
CANT1 calcium activated nucleotidase 1
CBS cystathionine-beta-synthase
CCNG1 cyclin G1
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDK19 cyclin-dependent kinase 19
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
COCH cochlin
CRABP2 cellular retinoic acid binding protein 2
CRP C-reactive protein, pentraxin-related
CSK c-src tyrosine kinase
CXCL12 chemokine (C-X-C motif) ligand 12
DEFB1 defensin, beta 1
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DPYD dihydropyrimidine dehydrogenase
DPYSL2 dihydropyrimidinase-like 2
ECM1 extracellular matrix protein 1
EIF5 eukaryotic translation initiation factor 5
ENDOD1 endonuclease domain containing 1
EVI2B ecotropic viral integration site 2B
EVL Enah/Vasp-like
FAM20B family with sequence similarity 20, member B
FAM3C family with sequence similarity 3, member C
FAP fibroblast activation protein, alpha
FBXO9 F-box protein 9
FSTL1 follistatin-like 1
GOLM1 golgi membrane protein 1
GPM6A glycoprotein M6A
GSTA1 glutathione S-transferase alpha 1
GYPC glycophorin C (Gerbich blood group)
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
IDO1 indoleamine 2,3-dioxygenase 1
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
INSIG1 insulin induced gene 1
KCTD12 potassium channel tetramerization domain containing 12
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3
KIAA0907 KIAA0907
LBH limb bud and heart development
LGR4 leucine-rich repeat containing G protein-coupled receptor 4
MAN1A1 mannosidase, alpha, class 1A, member 1
MAST2 microtubule associated serine/threonine kinase 2
MBTPS1 membrane-bound transcription factor peptidase, site 1
MELK maternal embryonic leucine zipper kinase
MICB MHC class I polypeptide-related sequence B
MME membrane metallo-endopeptidase
MS4A6A membrane-spanning 4-domains, subfamily A, member 6A
NCK2 NCK adaptor protein 2
NDRG2 NDRG family member 2
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NT5DC2 5'-nucleotidase domain containing 2
OLFML3 olfactomedin-like 3
PAM peptidylglycine alpha-amidating monooxygenase
PDGFD platelet derived growth factor D
PIR pirin (iron-binding nuclear protein)
PKM pyruvate kinase, muscle
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PRKD3 protein kinase D3
PRKX protein kinase, X-linked
RAB31 RAB31, member RAS oncogene family
RCAN1 regulator of calcineurin 1
RECK reversion-inducing-cysteine-rich protein with kazal motifs
RPL38 ribosomal protein L38
RPS11 ribosomal protein S11
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCGB2A1 secretoglobin, family 2A, member 1
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERINC5 serine incorporator 5
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SLC33A1 solute carrier family 33 (acetyl-CoA transporter), member 1
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLPI secretory leukocyte peptidase inhibitor
SNN stannin
SRGN serglycin
STARD7 StAR-related lipid transfer (START) domain containing 7
STK17A serine/threonine kinase 17a
STS steroid sulfatase (microsomal), isozyme S
TARP TCR gamma alternate reading frame protein
TATDN2 TatD DNase domain containing 2
TBC1D16 TBC1 domain family, member 16
TDO2 tryptophan 2,3-dioxygenase
TFDP1 transcription factor Dp-1
TMEM47 transmembrane protein 47
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TPBG trophoblast glycoprotein
TRAK2 trafficking protein, kinesin binding 2
TUBB tubulin, beta class I
WSB2 WD repeat and SOCS box containing 2
WWP1 WW domain containing E3 ubiquitin protein ligase 1
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
ZDHHC6 zinc finger, DHHC-type containing 6
ZIC1 Zic family member 1