BRD-K36038115_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

103 genes differentially expressed following the BRD-K36038115_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABHD4 abhydrolase domain containing 4
ADORA2B adenosine A2b receptor
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
BCHE butyrylcholinesterase
BLVRB biliverdin reductase B
CA12 carbonic anhydrase XII
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CD47 CD47 molecule
CDKN2A cyclin-dependent kinase inhibitor 2A
CLDN4 claudin 4
COLEC12 collectin sub-family member 12
COPS7A COP9 signalosome subunit 7A
CRABP2 cellular retinoic acid binding protein 2
CSTA cystatin A (stefin A)
EFS embryonal Fyn-associated substrate
EMP1 epithelial membrane protein 1
EPN2 epsin 2
F12 coagulation factor XII (Hageman factor)
G6PD glucose-6-phosphate dehydrogenase
GCLC glutamate-cysteine ligase, catalytic subunit
HOPX HOP homeobox
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit)
KRT13 keratin 13, type I
KRT5 keratin 5, type II
LAMA4 laminin, alpha 4
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MEST mesoderm specific transcript
NES nestin
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain)
NSG1 neuron specific gene family member 1
RGCC regulator of cell cycle
S100A2 S100 calcium binding protein A2
S100A9 S100 calcium binding protein A9
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SERPINB13 serpin peptidase inhibitor, clade B (ovalbumin), member 13
SFN stratifin
SFTPA2 surfactant protein A2
SFTPB surfactant protein B
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
TACSTD2 tumor-associated calcium signal transducer 2
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TRIM16 tripartite motif containing 16
TSKU tsukushi, small leucine rich proteoglycan
TUBB2A tubulin, beta 2A class IIa
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VEGFA vascular endothelial growth factor A
VPS72 vacuolar protein sorting 72 homolog (S. cerevisiae)
YBX3 Y box binding protein 3
ZNF395 zinc finger protein 395
ZNF586 zinc finger protein 586

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADD3 adducin 3 (gamma)
ADIRF adipogenesis regulatory factor
ALCAM activated leukocyte cell adhesion molecule
AREG amphiregulin
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
CGA glycoprotein hormones, alpha polypeptide
COL10A1 collagen, type X, alpha 1
COMP cartilage oligomeric matrix protein
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CYBA cytochrome b-245, alpha polypeptide
DACH1 dachshund family transcription factor 1
DACT1 dishevelled-binding antagonist of beta-catenin 1
DLK1 delta-like 1 homolog (Drosophila)
EFHD1 EF-hand domain family, member D1
EPHA3 EPH receptor A3
FBLN5 fibulin 5
FBN1 fibrillin 1
GCH1 GTP cyclohydrolase 1
HACD2 3-hydroxyacyl-CoA dehydratase 2
HIST1H4C histone cluster 1, H4c
HOXC6 homeobox C6
IL1R1 interleukin 1 receptor, type I
ITGAV integrin, alpha V
LEFTY1 left-right determination factor 1
LY75 lymphocyte antigen 75
NID2 nidogen 2 (osteonidogen)
NKTR natural killer cell triggering receptor
NPY1R neuropeptide Y receptor Y1
NTS neurotensin
PCDH9 protocadherin 9
PCSK1 proprotein convertase subtilisin/kexin type 1
PDE1A phosphodiesterase 1A, calmodulin-dependent
PEG3 paternally expressed 3
PIP4K2C phosphatidylinositol-5-phosphate 4-kinase, type II, gamma
PPM1H protein phosphatase, Mg2+/Mn2+ dependent, 1H
RBM34 RNA binding motif protein 34
RBP4 retinol binding protein 4, plasma
RPS11 ribosomal protein S11
S100P S100 calcium binding protein P
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINA6 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6
SFPQ splicing factor proline/glutamine-rich
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
THBS1 thrombospondin 1
TMEM47 transmembrane protein 47
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TSPYL5 TSPY-like 5
ZNF721 zinc finger protein 721