BRD-K36007650_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

129 genes differentially expressed following the BRD-K36007650_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
APOBEC3G apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
BBOX1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
BTG1 B-cell translocation gene 1, anti-proliferative
CA2 carbonic anhydrase II
CAST calpastatin
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CLCA4 chloride channel accessory 4
CX3CL1 chemokine (C-X3-C motif) ligand 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DENND1B DENN/MADD domain containing 1B
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
EIF5 eukaryotic translation initiation factor 5
ENC1 ectodermal-neural cortex 1 (with BTB domain)
FN1 fibronectin 1
FXYD6 FXYD domain containing ion transport regulator 6
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GADD45A growth arrest and DNA-damage-inducible, alpha
GRB7 growth factor receptor-bound protein 7
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HSPA13 heat shock protein 70kDa family, member 13
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
ICAM1 intercellular adhesion molecule 1
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IER5 immediate early response 5
IFNGR1 interferon gamma receptor 1
IFRD1 interferon-related developmental regulator 1
ITM2C integral membrane protein 2C
JUN jun proto-oncogene
KCTD5 potassium channel tetramerization domain containing 5
KLF6 Kruppel-like factor 6
KLF9 Kruppel-like factor 9
KRT23 keratin 23, type I
LGALS2 lectin, galactoside-binding, soluble, 2
LRMP lymphoid-restricted membrane protein
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MYC v-myc avian myelocytomatosis viral oncogene homolog
NET1 neuroepithelial cell transforming 1
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NT5E 5'-nucleotidase, ecto (CD73)
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PDZK1IP1 PDZK1 interacting protein 1
PHGDH phosphoglycerate dehydrogenase
PHLDA1 pleckstrin homology-like domain, family A, member 1
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPAP2B phosphatidic acid phosphatase type 2B
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PROM1 prominin 1
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RGS1 regulator of G-protein signaling 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SNAI2 snail family zinc finger 2
SWAP70 SWAP switching B-cell complex 70kDa subunit
TGFA transforming growth factor, alpha
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFRSF17 tumor necrosis factor receptor superfamily, member 17
TNNT1 troponin T type 1 (skeletal, slow)
TSC22D3 TSC22 domain family, member 3
TXNL4B thioredoxin-like 4B
UBE2J1 ubiquitin-conjugating enzyme E2, J1
WARS tryptophanyl-tRNA synthetase
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ADIRF adipogenesis regulatory factor
AGR2 anterior gradient 2
ALCAM activated leukocyte cell adhesion molecule
ASCL1 achaete-scute family bHLH transcription factor 1
ATF5 activating transcription factor 5
B3GNT1
BASP1 brain abundant, membrane attached signal protein 1
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
DHRS1 dehydrogenase/reductase (SDR family) member 1
DSP desmoplakin
EPB41L4B erythrocyte membrane protein band 4.1 like 4B
EPCAM epithelial cell adhesion molecule
ERBB2 erb-b2 receptor tyrosine kinase 2
FASTKD5 FAST kinase domains 5
GPD1L glycerol-3-phosphate dehydrogenase 1-like
GPX3 glutathione peroxidase 3
GRWD1 glutamate-rich WD repeat containing 1
HOXC6 homeobox C6
IFI30 interferon, gamma-inducible protein 30
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains)
KANK2 KN motif and ankyrin repeat domains 2
KDM4B lysine (K)-specific demethylase 4B
KLK11 kallikrein-related peptidase 11
LEPR leptin receptor
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LIG1 ligase I, DNA, ATP-dependent
LUC7L3 LUC7-like 3 (S. cerevisiae)
MEGF9 multiple EGF-like-domains 9
MFSD10 major facilitator superfamily domain containing 10
MSLN mesothelin
NEFH neurofilament, heavy polypeptide
NR2F1 nuclear receptor subfamily 2, group F, member 1
PCP4 Purkinje cell protein 4
PGD phosphogluconate dehydrogenase
PRPF19 pre-mRNA processing factor 19
PRSS23 protease, serine, 23
RAB31 RAB31, member RAS oncogene family
RAD51C RAD51 paralog C
RPS4Y1 ribosomal protein S4, Y-linked 1
SFN stratifin
SIDT2 SID1 transmembrane family, member 2
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SLPI secretory leukocyte peptidase inhibitor
SORD sorbitol dehydrogenase
TACSTD2 tumor-associated calcium signal transducer 2
TARBP1 TAR (HIV-1) RNA binding protein 1
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
TM7SF2 transmembrane 7 superfamily member 2
TRAPPC3 trafficking protein particle complex 3
TSPAN13 tetraspanin 13
TSPAN8 tetraspanin 8
UBL3 ubiquitin-like 3
UTP3 UTP3, small subunit (SSU) processome component, homolog (S. cerevisiae)
ZNF185 zinc finger protein 185 (LIM domain)