BRD-K36007650_-666_HT29_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

124 genes differentially expressed following the BRD-K36007650_-666_HT29_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ABAT 4-aminobutyrate aminotransferase
ACSL3 acyl-CoA synthetase long-chain family member 3
ARMCX3 armadillo repeat containing, X-linked 3
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
BAG3 BCL2-associated athanogene 3
BUD31 BUD31 homolog (S. cerevisiae)
C5AR1 complement component 5a receptor 1
CARS cysteinyl-tRNA synthetase
CBS cystathionine-beta-synthase
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
COL11A1 collagen, type XI, alpha 1
COL1A1 collagen, type I, alpha 1
CXCL13 chemokine (C-X-C motif) ligand 13
DCN decorin
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DLK1 delta-like 1 homolog (Drosophila)
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP1 dual specificity phosphatase 1
EGFR epidermal growth factor receptor
EGR1 early growth response 1
EPRS glutamyl-prolyl-tRNA synthetase
EZR ezrin
FHL2 four and a half LIM domains 2
FOSL1 FOS-like antigen 1
GABPB1 GA binding protein transcription factor, beta subunit 1
GARS glycyl-tRNA synthetase
GPRC5A G protein-coupled receptor, class C, group 5, member A
GSTA1 glutathione S-transferase alpha 1
HBEGF heparin-binding EGF-like growth factor
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HSPA13 heat shock protein 70kDa family, member 13
HSPA1A heat shock 70kDa protein 1A
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPB1 heat shock 27kDa protein 1
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPH1 heat shock 105kDa/110kDa protein 1
IFI27 interferon, alpha-inducible protein 27
IFI6 interferon, alpha-inducible protein 6
IFRD1 interferon-related developmental regulator 1
IGHD immunoglobulin heavy constant delta
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
IGLJ3 immunoglobulin lambda joining 3
IGLV3-19 immunoglobulin lambda variable 3-19
IL6ST interleukin 6 signal transducer
IRS2 insulin receptor substrate 2
JMJD6 jumonji domain containing 6
JUN jun proto-oncogene
JUND jun D proto-oncogene
KLF9 Kruppel-like factor 9
LDLR low density lipoprotein receptor
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MARCH6 membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase
MARS methionyl-tRNA synthetase
MBNL2 muscleblind-like splicing regulator 2
MCL1 myeloid cell leukemia 1
MIR22HG MIR22 host gene
MLF1 myeloid leukemia factor 1
MT1E metallothionein 1E
NFIL3 nuclear factor, interleukin 3 regulated
NPC1 Niemann-Pick disease, type C1
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
NRIP1 nuclear receptor interacting protein 1
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PER1 period circadian clock 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGS1 regulator of G-protein signaling 1
RHOB ras homolog family member B
RIOK3 RIO kinase 3
SERP1 stress-associated endoplasmic reticulum protein 1
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SH3TC1 SH3 domain and tetratricopeptide repeats 1
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
STAR steroidogenic acute regulatory protein
TARS threonyl-tRNA synthetase
THBS1 thrombospondin 1
TRIB3 tribbles pseudokinase 3
TSC22D3 TSC22 domain family, member 3
XBP1 X-box binding protein 1

decreased expression

Symbol Name
AQP3 aquaporin 3 (Gill blood group)
CA12 carbonic anhydrase XII
CCL4 chemokine (C-C motif) ligand 4
CCNA2 cyclin A2
CCNF cyclin F
CLIC3 chloride intracellular channel 3
CXCL9 chemokine (C-X-C motif) ligand 9
DACH1 dachshund family transcription factor 1
ENC1 ectodermal-neural cortex 1 (with BTB domain)
FBLN1 fibulin 1
GATA2 GATA binding protein 2
KANK1 KN motif and ankyrin repeat domains 1
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KIF20A kinesin family member 20A
MREG melanoregulin
MYH11 myosin, heavy chain 11, smooth muscle
NRGN neurogranin (protein kinase C substrate, RC3)
NRN1 neuritin 1
PDZRN3 PDZ domain containing ring finger 3
PODXL podocalyxin-like
PPAP2B phosphatidic acid phosphatase type 2B
RAB25 RAB25, member RAS oncogene family
S100A8 S100 calcium binding protein A8
SPRR1A small proline-rich protein 1A
STC1 stanniocalcin 1
TARBP1 TAR (HIV-1) RNA binding protein 1
TMEM109 transmembrane protein 109
WDTC1 WD and tetratricopeptide repeats 1