BRD-K35716340_-666_HA1E_6.0_h_12.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

114 genes differentially expressed following the BRD-K35716340_-666_HA1E_6.0_h_12.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD6 abhydrolase domain containing 6
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2
BGN biglycan
CA2 carbonic anhydrase II
CCND2 cyclin D2
CD24 CD24 molecule
CD40 CD40 molecule, TNF receptor superfamily member 5
CD52 CD52 molecule
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CTSZ cathepsin Z
CXCL9 chemokine (C-X-C motif) ligand 9
DYNLT3 dynein, light chain, Tctex-type 3
FGFR3 fibroblast growth factor receptor 3
FN1 fibronectin 1
GFOD1 glucose-fructose oxidoreductase domain containing 1
GRB7 growth factor receptor-bound protein 7
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
KCTD12 potassium channel tetramerization domain containing 12
LMO3 LIM domain only 3 (rhombotin-like 2)
MKNK1 MAP kinase interacting serine/threonine kinase 1
MMP9 matrix metallopeptidase 9
MYO1B myosin IB
MYO6 myosin VI
OBSL1 obscurin-like 1
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PON3 paraoxonase 3
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PSMF1 proteasome (prosome, macropain) inhibitor subunit 1 (PI31)
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RGCC regulator of cell cycle
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SIRPA signal-regulatory protein alpha
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3
SLCO3A1 solute carrier organic anion transporter family, member 3A1
SNX13 sorting nexin 13
SOX11 SRY (sex determining region Y)-box 11
TRD T cell receptor delta locus
TRIB3 tribbles pseudokinase 3
TYROBP TYRO protein tyrosine kinase binding protein
XIST X inactive specific transcript (non-protein coding)
ZNF395 zinc finger protein 395

decreased expression

Symbol Name
ABHD2 abhydrolase domain containing 2
AKAP12 A kinase (PRKA) anchor protein 12
ANO10 anoctamin 10
APOD apolipoprotein D
ASCC3 activating signal cointegrator 1 complex subunit 3
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BACE2 beta-site APP-cleaving enzyme 2
BBX bobby sox homolog (Drosophila)
C8ORF4 chromosome 8 open reading frame 4
CDC20 cell division cycle 20
CSRP1 cysteine and glycine-rich protein 1
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DICER1 dicer 1, ribonuclease type III
DLC1 DLC1 Rho GTPase activating protein
ECI2 enoyl-CoA delta isomerase 2
F2RL1 coagulation factor II (thrombin) receptor-like 1
FOLR1 folate receptor 1 (adult)
GMDS GDP-mannose 4,6-dehydratase
GPM6B glycoprotein M6B
GPR137B G protein-coupled receptor 137B
GULP1 GULP, engulfment adaptor PTB domain containing 1
HMG20B high mobility group 20B
HOXA5 homeobox A5
HOXC6 homeobox C6
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
LTBP3 latent transforming growth factor beta binding protein 3
MATN2 matrilin 2
MT1X metallothionein 1X
NFIB nuclear factor I/B
NKX3-1 NK3 homeobox 1
NRIP1 nuclear receptor interacting protein 1
PCM1 pericentriolar material 1
PCP4 Purkinje cell protein 4
PDGFRL platelet-derived growth factor receptor-like
PFN2 profilin 2
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PIR pirin (iron-binding nuclear protein)
PKN2 protein kinase N2
RAD51C RAD51 paralog C
RHOQ ras homolog family member Q
RRAGD Ras-related GTP binding D
SACS sacsin molecular chaperone
SFN stratifin
SIX1 SIX homeobox 1
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SLIT2 slit homolog 2 (Drosophila)
SMAD3 SMAD family member 3
SRPX sushi-repeat containing protein, X-linked
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
TBC1D4 TBC1 domain family, member 4
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TNPO1 transportin 1
TTC3 tetratricopeptide repeat domain 3
UBE2S ubiquitin-conjugating enzyme E2S
UGCG UDP-glucose ceramide glucosyltransferase
ZBTB20 zinc finger and BTB domain containing 20
ZCCHC24 zinc finger, CCHC domain containing 24