BRD-K35708212_Strophantine octahydrate_PC3_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

172 genes differentially expressed following the BRD-K35708212_Strophantine octahydrate_PC3_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
AIF1 allograft inflammatory factor 1
AKAP8L A kinase (PRKA) anchor protein 8-like
ANOS1 anosmin 1
AREG amphiregulin
ARL8B ADP-ribosylation factor-like 8B
ATF3 activating transcription factor 3
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BMP2 bone morphogenetic protein 2
C3 complement component 3
C5AR1 complement component 5a receptor 1
CADM1 cell adhesion molecule 1
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCL20 chemokine (C-C motif) ligand 20
CCNL1 cyclin L1
CD163 CD163 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CGA glycoprotein hormones, alpha polypeptide
CLU clusterin
COX17 COX17 cytochrome c oxidase copper chaperone
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL5 chemokine (C-X-C motif) ligand 5
CXCL8 chemokine (C-X-C motif) ligand 8
CYR61 cysteine-rich, angiogenic inducer, 61
DUSP1 dual specificity phosphatase 1
EDN1 endothelin 1
EFNA1 ephrin-A1
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
F3 coagulation factor III (thromboplastin, tissue factor)
FBN2 fibrillin 2
FNDC3B fibronectin type III domain containing 3B
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOXF1 forkhead box F1
FST follistatin
GABPB1 GA binding protein transcription factor, beta subunit 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GBP1 guanylate binding protein 1, interferon-inducible
GLUL glutamate-ammonia ligase
GSTP1 glutathione S-transferase pi 1
HBEGF heparin-binding EGF-like growth factor
HCAR3 hydroxycarboxylic acid receptor 3
HIST1H1C histone cluster 1, H1c
HIST1H2BD histone cluster 1, H2bd
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
ICAM1 intercellular adhesion molecule 1
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IL1B interleukin 1, beta
IL6 interleukin 6
IPW imprinted in Prader-Willi syndrome (non-protein coding)
JUN jun proto-oncogene
KLF6 Kruppel-like factor 6
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP3K8 mitogen-activated protein kinase kinase kinase 8
MIR22HG MIR22 host gene
MMP19 matrix metallopeptidase 19
MMP9 matrix metallopeptidase 9
NACA nascent polypeptide-associated complex alpha subunit
NDRG1 N-myc downstream regulated 1
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NINJ1 ninjurin 1
NPC1 Niemann-Pick disease, type C1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
NRG1 neuregulin 1
OPHN1 oligophrenin 1
OXSR1 oxidative stress responsive 1
PAN2 PAN2 poly(A) specific ribonuclease subunit
PEG3 paternally expressed 3
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PILRB paired immunoglobin-like type 2 receptor beta
PLAUR plasminogen activator, urokinase receptor
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PLXNB1 plexin B1
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PNISR PNN-interacting serine/arginine-rich protein
PPIF peptidylprolyl isomerase F
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTX3 pentraxin 3, long
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGS1 regulator of G-protein signaling 1
RGS2 regulator of G-protein signaling 2
RPS21 ribosomal protein S21
SAT1 spermidine/spermine N1-acetyltransferase 1
SCD5 stearoyl-CoA desaturase 5
SELE selectin E
SEPP1 selenoprotein P, plasma, 1
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SIK1 salt-inducible kinase 1
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLPI secretory leukocyte peptidase inhibitor
SOD2 superoxide dismutase 2, mitochondrial
SRSF5 serine/arginine-rich splicing factor 5
THY1 Thy-1 cell surface antigen
TICAM1 toll-like receptor adaptor molecule 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNIP1 TNFAIP3 interacting protein 1
TNS3 tensin 3
ZBED2 zinc finger, BED-type containing 2
ZC3H12A zinc finger CCCH-type containing 12A
ZFP36 ZFP36 ring finger protein
ZNF331 zinc finger protein 331

decreased expression

Symbol Name
ADO 2-aminoethanethiol (cysteamine) dioxygenase
ATMIN ATM interactor
BAG3 BCL2-associated athanogene 3
C14ORF132 chromosome 14 open reading frame 132
CACYBP calcyclin binding protein
CBR3 carbonyl reductase 3
CCNA2 cyclin A2
CDC25B cell division cycle 25B
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CGRRF1 cell growth regulator with ring finger domain 1
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CRYM crystallin, mu
CSTF2T cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa, tau variant
DPP4 dipeptidyl-peptidase 4
DUSP22 dual specificity phosphatase 22
EGR2 early growth response 2
FABP6 fatty acid binding protein 6, ileal
FAM129A family with sequence similarity 129, member A
FZD2 frizzled class receptor 2
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GAGE3 G antigen 3
GAS1 growth arrest-specific 1
GATA3 GATA binding protein 3
GNG11 guanine nucleotide binding protein (G protein), gamma 11
HOXA10 homeobox A10
HOXB2 homeobox B2
HOXB7 homeobox B7
HOXC6 homeobox C6
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
IGL immunoglobulin lambda locus
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
KCNS3 potassium voltage-gated channel, modifier subfamily S, member 3
KRT15 keratin 15, type I
LGALS3 lectin, galactoside-binding, soluble, 3
LINC00341 long intergenic non-protein coding RNA 341
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MTSS1 metastasis suppressor 1
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NES nestin
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
PLEKHF2 pleckstrin homology domain containing, family F (with FYVE domain) member 2
PPP1R3C protein phosphatase 1, regulatory subunit 3C
RBM15B RNA binding motif protein 15B
RRAGA Ras-related GTP binding A
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TMEM158 transmembrane protein 158 (gene/pseudogene)
TRIB2 tribbles pseudokinase 2
TXNDC9 thioredoxin domain containing 9
UBL4A ubiquitin-like 4A
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta