BRD-K35708212_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

180 genes differentially expressed following the BRD-K35708212_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
AKAP8L A kinase (PRKA) anchor protein 8-like
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
APLP2 amyloid beta (A4) precursor-like protein 2
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BRD4 bromodomain containing 4
BTG3 BTG family, member 3
CCL20 chemokine (C-C motif) ligand 20
CDC25A cell division cycle 25A
CDC42 cell division cycle 42
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHERP calcium homeostasis endoplasmic reticulum protein
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
COL11A1 collagen, type XI, alpha 1
COL15A1 collagen, type XV, alpha 1
COL1A1 collagen, type I, alpha 1
COL6A2 collagen, type VI, alpha 2
CTGF connective tissue growth factor
CTSV cathepsin V
CXCL8 chemokine (C-X-C motif) ligand 8
CYBRD1 cytochrome b reductase 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
DHCR7 7-dehydrocholesterol reductase
DLX2 distal-less homeobox 2
DMTF1 cyclin D binding myb-like transcription factor 1
EGR1 early growth response 1
EIF5A eukaryotic translation initiation factor 5A
ELF1 E74-like factor 1 (ets domain transcription factor)
FAM60A family with sequence similarity 60, member A
FBLN1 fibulin 1
FKBP14 FK506 binding protein 14, 22 kDa
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOXJ3 forkhead box J3
FOXO1 forkhead box O1
GADD45B growth arrest and DNA-damage-inducible, beta
GATA3 GATA binding protein 3
GLUL glutamate-ammonia ligase
GSTM3 glutathione S-transferase mu 3 (brain)
GSTP1 glutathione S-transferase pi 1
H1FX H1 histone family, member X
HEG1 heart development protein with EGF-like domains 1
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
HES1 hes family bHLH transcription factor 1
HIST1H1C histone cluster 1, H1c
HIST1H2BC histone cluster 1, H2bc
HIST1H2BG histone cluster 1, H2bg
HMGB2 high mobility group box 2
HNRNPL heterogeneous nuclear ribonucleoprotein L
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IER2 immediate early response 2
IER3 immediate early response 3
IGFBP5 insulin-like growth factor binding protein 5
IL6 interleukin 6
INHBA inhibin, beta A
INSIG1 insulin induced gene 1
JUN jun proto-oncogene
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15
KDM3A lysine (K)-specific demethylase 3A
KLF6 Kruppel-like factor 6
LDLR low density lipoprotein receptor
LPIN1 lipin 1
LTF lactotransferrin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAN1A1 mannosidase, alpha, class 1A, member 1
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MDK midkine (neurite growth-promoting factor 2)
MFAP5 microfibrillar associated protein 5
MMP9 matrix metallopeptidase 9
MXRA5 matrix-remodelling associated 5
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NUSAP1 nucleolar and spindle associated protein 1
PCDH9 protocadherin 9
PLAU plasminogen activator, urokinase
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PSPC1 paraspeckle component 1
RAD9A RAD9 homolog A (S. pombe)
RBP4 retinol binding protein 4, plasma
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGCC regulator of cell cycle
RYBP RING1 and YY1 binding protein
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SFRP1 secreted frizzled-related protein 1
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SMAD7 SMAD family member 7
SNRK SNF related kinase
STOM stomatin
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TSKU tsukushi, small leucine rich proteoglycan
TUFT1 tuftelin 1
TXNIP thioredoxin interacting protein
UFM1 ubiquitin-fold modifier 1
WEE1 WEE1 G2 checkpoint kinase
ZFP36 ZFP36 ring finger protein
ZFP36L1 ZFP36 ring finger protein-like 1
ZFP36L2 ZFP36 ring finger protein-like 2

decreased expression

Symbol Name
AMZ2 archaelysin family metallopeptidase 2
ANXA6 annexin A6
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
ATMIN ATM interactor
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4
B3GNT1
C1ORF116 chromosome 1 open reading frame 116
C1QB complement component 1, q subcomponent, B chain
C2CD5 C2 calcium-dependent domain containing 5
C6ORF62 chromosome 6 open reading frame 62
CANT1 calcium activated nucleotidase 1
CBR3 carbonyl reductase 3
CBX6 chromobox homolog 6
CCNF cyclin F
CD14 CD14 molecule
CSK c-src tyrosine kinase
CTSL cathepsin L
CX3CR1 chemokine (C-X3-C motif) receptor 1
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
EIF5 eukaryotic translation initiation factor 5
F12 coagulation factor XII (Hageman factor)
FANCF Fanconi anemia, complementation group F
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
HMG20B high mobility group 20B
HMOX1 heme oxygenase 1
HSPA8 heat shock 70kDa protein 8
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGLV2-23 immunoglobulin lambda variable 2-23
INTS3 integrator complex subunit 3
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
KAZN kazrin, periplakin interacting protein
KCNN2 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2
LOC100505650 uncharacterized LOC100505650
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAT2A methionine adenosyltransferase II, alpha
MEIS1 Meis homeobox 1
METTL13 methyltransferase like 13
MS4A6A membrane-spanning 4-domains, subfamily A, member 6A
MSMB microseminoprotein, beta-
NES nestin
NNMT nicotinamide N-methyltransferase
NREP neuronal regeneration related protein
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
PRR7 proline rich 7 (synaptic)
PRUNE2 prune homolog 2 (Drosophila)
PWP1 PWP1 homolog (S. cerevisiae)
RAP2A RAP2A, member of RAS oncogene family
RNASE6 ribonuclease, RNase A family, k6
RPS4Y1 ribosomal protein S4, Y-linked 1
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SEPT9 septin 9
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4
SRSF7 serine/arginine-rich splicing factor 7
STEAP3 STEAP family member 3, metalloreductase
TSEN2 TSEN2 tRNA splicing endonuclease subunit
TSPAN12 tetraspanin 12
TUBB tubulin, beta class I
USP34 ubiquitin specific peptidase 34
XBP1 X-box binding protein 1
ZBTB20 zinc finger and BTB domain containing 20
ZNF185 zinc finger protein 185 (LIM domain)