BRD-K35708212_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

114 genes differentially expressed following the BRD-K35708212_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKIRIN1 akirin 1
ARF4 ADP-ribosylation factor 4
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
ATP6V1G1 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1
BIRC2 baculoviral IAP repeat containing 2
CCL20 chemokine (C-C motif) ligand 20
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CELF2 CUGBP, Elav-like family member 2
CHIC2 cysteine-rich hydrophobic domain 2
CTSB cathepsin B
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CYR61 cysteine-rich, angiogenic inducer, 61
DUSP6 dual specificity phosphatase 6
EBP emopamil binding protein (sterol isomerase)
EFNA1 ephrin-A1
EGR1 early growth response 1
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GNAS GNAS complex locus
H1F0 H1 histone family, member 0
HES1 hes family bHLH transcription factor 1
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IFRD2 interferon-related developmental regulator 2
IGHM immunoglobulin heavy constant mu
INSR insulin receptor
JARID2 jumonji, AT rich interactive domain 2
JMJD1C jumonji domain containing 1C
JUN jun proto-oncogene
JUNB jun B proto-oncogene
JUND jun D proto-oncogene
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NPC2 Niemann-Pick disease, type C2
NUPL1 nucleoporin like 1
OPN3 opsin 3
PER2 period circadian clock 2
PHACTR2 phosphatase and actin regulator 2
PLAGL1 pleiomorphic adenoma gene-like 1
RALGDS ral guanine nucleotide dissociation stimulator
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RB1CC1 RB1-inducible coiled-coil 1
RGS1 regulator of G-protein signaling 1
RYBP RING1 and YY1 binding protein
SEPP1 selenoprotein P, plasma, 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SMAD3 SMAD family member 3
SPATS2L spermatogenesis associated, serine-rich 2-like
STK17A serine/threonine kinase 17a
STOM stomatin
TGM2 transglutaminase 2
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNPO1 transportin 1
TSC22D2 TSC22 domain family, member 2
TXNIP thioredoxin interacting protein
UGCG UDP-glucose ceramide glucosyltransferase
ZMYM2 zinc finger, MYM-type 2

decreased expression

Symbol Name
ACTG2 actin, gamma 2, smooth muscle, enteric
ADD3 adducin 3 (gamma)
AMIGO2 adhesion molecule with Ig-like domain 2
CA12 carbonic anhydrase XII
CASP1 caspase 1, apoptosis-related cysteine peptidase
CD40 CD40 molecule, TNF receptor superfamily member 5
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
COL1A2 collagen, type I, alpha 2
CPB1 carboxypeptidase B1 (tissue)
CRIP1 cysteine-rich protein 1 (intestinal)
CRYAB crystallin, alpha B
CSRP1 cysteine and glycine-rich protein 1
CSTA cystatin A (stefin A)
CYBB cytochrome b-245, beta polypeptide
DCN decorin
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6
DPYSL2 dihydropyrimidinase-like 2
DPYSL3 dihydropyrimidinase-like 3
EIF5 eukaryotic translation initiation factor 5
ELANE elastase, neutrophil expressed
FAM198B family with sequence similarity 198, member B
G0S2 G0/G1 switch 2
HBB hemoglobin, beta
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IGFBP7 insulin-like growth factor binding protein 7
LDHB lactate dehydrogenase B
MME membrane metallo-endopeptidase
MMP12 matrix metallopeptidase 12
POSTN periostin, osteoblast specific factor
PRPF4 pre-mRNA processing factor 4
PRTN3 proteinase 3
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
S100A8 S100 calcium binding protein A8
SEMA6A sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SLCO3A1 solute carrier organic anion transporter family, member 3A1
SRGN serglycin
STEAP1 six transmembrane epithelial antigen of the prostate 1
SYNM synemin, intermediate filament protein
TBX3 T-box 3
TLR4 toll-like receptor 4
VCAN versican
WNT5A wingless-type MMTV integration site family, member 5A
ZDHHC11 zinc finger, DHHC-type containing 11
ZNF586 zinc finger protein 586