BRD-K35638681_-666_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

133 genes differentially expressed following the BRD-K35638681_-666_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ADGRE5 adhesion G protein-coupled receptor E5
ADM adrenomedullin
AKR1C3 aldo-keto reductase family 1, member C3
ALDOC aldolase C, fructose-bisphosphate
ANGPTL4 angiopoietin-like 4
ANXA1 annexin A1
ANXA4 annexin A4
APOL1 apolipoprotein L, 1
C3 complement component 3
CA12 carbonic anhydrase XII
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CFB complement factor B
COL4A5 collagen, type IV, alpha 5
CTSL cathepsin L
CYP2B7P cytochrome P450, family 2, subfamily B, polypeptide 7, pseudogene
DDIT4 DNA-damage-inducible transcript 4
DFNA5 deafness, autosomal dominant 5
DHRS3 dehydrogenase/reductase (SDR family) member 3
ENO2 enolase 2 (gamma, neuronal)
EPAS1 endothelial PAS domain protein 1
FADS1 fatty acid desaturase 1
FAP fibroblast activation protein, alpha
FBLN1 fibulin 1
FCGR1B Fc fragment of IgG, high affinity Ib, receptor (CD64)
FTH1 ferritin, heavy polypeptide 1
FZD2 frizzled class receptor 2
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GDF15 growth differentiation factor 15
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5
GLRX glutaredoxin (thioltransferase)
GPR161 G protein-coupled receptor 161
HBE1 hemoglobin, epsilon 1
HEPH hephaestin
HK2 hexokinase 2
HMOX1 heme oxygenase 1
HSPA2 heat shock 70kDa protein 2
IER3 immediate early response 3
IFI16 interferon, gamma-inducible protein 16
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
KRT81 keratin 81, type II
LAMB1 laminin, beta 1
LAPTM5 lysosomal protein transmembrane 5
LGALS1 lectin, galactoside-binding, soluble, 1
LIMCH1 LIM and calponin homology domains 1
LINC00341 long intergenic non-protein coding RNA 341
LOC100505650 uncharacterized LOC100505650
LOXL2 lysyl oxidase-like 2
LRRC15 leucine rich repeat containing 15
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MMD monocyte to macrophage differentiation-associated
MMP11 matrix metallopeptidase 11
MSN moesin
MYRF myelin regulatory factor
NDRG1 N-myc downstream regulated 1
NELL2 NEL-like 2 (chicken)
NNMT nicotinamide N-methyltransferase
NTS neurotensin
NUCB2 nucleobindin 2
NUPR1 nuclear protein, transcriptional regulator, 1
PAM peptidylglycine alpha-amidating monooxygenase
PBX1 pre-B-cell leukemia homeobox 1
PFKM phosphofructokinase, muscle
PGM1 phosphoglucomutase 1
PLAU plasminogen activator, urokinase
PLIN2 perilipin 2
PRAME preferentially expressed antigen in melanoma
PROCR protein C receptor, endothelial
PRSS8 protease, serine, 8
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RBP4 retinol binding protein 4, plasma
RHOBTB3 Rho-related BTB domain containing 3
S100A4 S100 calcium binding protein A4
S100A8 S100 calcium binding protein A8
SAT1 spermidine/spermine N1-acetyltransferase 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SCGB2A2 secretoglobin, family 2A, member 2
SCPEP1 serine carboxypeptidase 1
SELENBP1 selenium binding protein 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
STC1 stanniocalcin 1
TMSB15A thymosin beta 15a
TPSAB1 tryptase alpha/beta 1
TRIM2 tripartite motif containing 2
TSKU tsukushi, small leucine rich proteoglycan
UBE2L6 ubiquitin-conjugating enzyme E2L 6
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VCAN versican
VTCN1 V-set domain containing T cell activation inhibitor 1
WNT5A wingless-type MMTV integration site family, member 5A
XIST X inactive specific transcript (non-protein coding)
ZFP36L1 ZFP36 ring finger protein-like 1

decreased expression

Symbol Name
ADI1 acireductone dioxygenase 1
ATF1 activating transcription factor 1
CALB1 calbindin 1, 28kDa
CCNA2 cyclin A2
CENPU centromere protein U
CXCL12 chemokine (C-X-C motif) ligand 12
CYC1 cytochrome c-1
DBF4 DBF4 zinc finger
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DPH2 DPH2 homolog (S. cerevisiae)
EGR3 early growth response 3
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
FABP5 fatty acid binding protein 5 (psoriasis-associated)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GRWD1 glutamate-rich WD repeat containing 1
ICAM3 intercellular adhesion molecule 3
IFRD2 interferon-related developmental regulator 2
KDM5D lysine (K)-specific demethylase 5D
LIG1 ligase I, DNA, ATP-dependent
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MCM4 minichromosome maintenance complex component 4
MYCBP MYC binding protein
ODC1 ornithine decarboxylase 1
PEBP1 phosphatidylethanolamine binding protein 1
PNN pinin, desmosome associated protein
PPIF peptidylprolyl isomerase F
RFC5 replication factor C (activator 1) 5, 36.5kDa
RPL37A ribosomal protein L37a
RPS4Y1 ribosomal protein S4, Y-linked 1
SCUBE2 signal peptide, CUB domain, EGF-like 2
TRIP13 thyroid hormone receptor interactor 13
TSPYL5 TSPY-like 5
VRK1 vaccinia related kinase 1