BRD-K35638681_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

75 genes differentially expressed following the BRD-K35638681_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
A2M alpha-2-macroglobulin
ADGRE5 adhesion G protein-coupled receptor E5
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALB albumin
ARG2 arginase 2
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2
C10ORF10 chromosome 10 open reading frame 10
CA2 carbonic anhydrase II
CD24 CD24 molecule
CD96 CD96 molecule
CMAHP cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene
CRABP2 cellular retinoic acid binding protein 2
CTNND1 catenin (cadherin-associated protein), delta 1
EPAS1 endothelial PAS domain protein 1
ERBB3 erb-b2 receptor tyrosine kinase 3
EXT1 exostosin glycosyltransferase 1
FHL1 four and a half LIM domains 1
GLRX glutaredoxin (thioltransferase)
HIST1H1C histone cluster 1, H1c
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IL32 interleukin 32
KRT23 keratin 23, type I
MVP major vault protein
NIT1 nitrilase 1
NNMT nicotinamide N-methyltransferase
PDE8B phosphodiesterase 8B
PEG10 paternally expressed 10
PLK1 polo-like kinase 1
POSTN periostin, osteoblast specific factor
PPAP2A phosphatidic acid phosphatase type 2A
RAD21 RAD21 homolog (S. pombe)
SCGB2A1 secretoglobin, family 2A, member 1
SPRED2 sprouty-related, EVH1 domain containing 2
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
TMEM2 transmembrane protein 2
TNNT1 troponin T type 1 (skeletal, slow)
TSPAN13 tetraspanin 13
XIST X inactive specific transcript (non-protein coding)
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AK4 adenylate kinase 4
AKAP8 A kinase (PRKA) anchor protein 8
ATF5 activating transcription factor 5
CCND1 cyclin D1
CDC25A cell division cycle 25A
CXCL5 chemokine (C-X-C motif) ligand 5
CXCL8 chemokine (C-X-C motif) ligand 8
DAPK1 death-associated protein kinase 1
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
EGFR epidermal growth factor receptor
ENC1 ectodermal-neural cortex 1 (with BTB domain)
GADD45B growth arrest and DNA-damage-inducible, beta
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HS3ST1 heparan sulfate (glucosamine) 3-O-sulfotransferase 1
HSPA1A heat shock 70kDa protein 1A
HSPH1 heat shock 105kDa/110kDa protein 1
LCN2 lipocalin 2
LTF lactotransferrin
MMP12 matrix metallopeptidase 12
MRPS2 mitochondrial ribosomal protein S2
MUC5B mucin 5B, oligomeric mucus/gel-forming
NIP7 NIP7, nucleolar pre-rRNA processing protein
PTX3 pentraxin 3, long
SPRY2 sprouty homolog 2 (Drosophila)
SRRM2 serine/arginine repetitive matrix 2
SRSF7 serine/arginine-rich splicing factor 7
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
ZBTB18 zinc finger and BTB domain containing 18