BRD-K35424586_-666_VCAP_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

251 genes differentially expressed following the BRD-K35424586_-666_VCAP_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AAMDC adipogenesis associated, Mth938 domain containing
ABLIM1 actin binding LIM protein 1
ACTN1 actinin, alpha 1
ADD3 adducin 3 (gamma)
ADGRG6 adhesion G protein-coupled receptor G6
AKAP12 A kinase (PRKA) anchor protein 12
AKAP13 A kinase (PRKA) anchor protein 13
ALAS2 5'-aminolevulinate synthase 2
AMIGO2 adhesion molecule with Ig-like domain 2
ANKMY2 ankyrin repeat and MYND domain containing 2
AREG amphiregulin
ASPH aspartate beta-hydroxylase
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BAMBI BMP and activin membrane-bound inhibitor
BASP1 brain abundant, membrane attached signal protein 1
BIRC2 baculoviral IAP repeat containing 2
BTG1 B-cell translocation gene 1, anti-proliferative
CA2 carbonic anhydrase II
CALD1 caldesmon 1
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast)
CCND1 cyclin D1
CCNG2 cyclin G2
CD24 CD24 molecule
CD36 CD36 molecule (thrombospondin receptor)
CDC42 cell division cycle 42
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN2A cyclin-dependent kinase inhibitor 2A
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CLIC4 chloride intracellular channel 4
CREB3L2 cAMP responsive element binding protein 3-like 2
CSRP2 cysteine and glycine-rich protein 2
CSTA cystatin A (stefin A)
CTSL cathepsin L
CTSV cathepsin V
DDIT4 DNA-damage-inducible transcript 4
DSP desmoplakin
DSTN destrin (actin depolymerizing factor)
DUSP4 dual specificity phosphatase 4
EFHD1 EF-hand domain family, member D1
ENC1 ectodermal-neural cortex 1 (with BTB domain)
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
EVL Enah/Vasp-like
FAM46A family with sequence similarity 46, member A
FAT1 FAT atypical cadherin 1
FERMT2 fermitin family member 2
FHL1 four and a half LIM domains 1
FKBP1B FK506 binding protein 1B, 12.6 kDa
FNDC3B fibronectin type III domain containing 3B
FOXO3 forkhead box O3
FOXO4 forkhead box O4
FYN FYN proto-oncogene, Src family tyrosine kinase
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GADD45A growth arrest and DNA-damage-inducible, alpha
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GLRX glutaredoxin (thioltransferase)
GLUL glutamate-ammonia ligase
GPM6B glycoprotein M6B
GPR161 G protein-coupled receptor 161
GPRC5A G protein-coupled receptor, class C, group 5, member A
GRB10 growth factor receptor-bound protein 10
GSN gelsolin
HEBP1 heme binding protein 1
HECA headcase homolog (Drosophila)
HES1 hes family bHLH transcription factor 1
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IGSF3 immunoglobulin superfamily, member 3
INHBA inhibin, beta A
ITGA6 integrin, alpha 6
JARID2 jumonji, AT rich interactive domain 2
JUN jun proto-oncogene
KLF6 Kruppel-like factor 6
KLF7 Kruppel-like factor 7 (ubiquitous)
KLF9 Kruppel-like factor 9
KRT18 keratin 18, type I
LAMA3 laminin, alpha 3
LGMN legumain
LITAF lipopolysaccharide-induced TNF factor
LMCD1 LIM and cysteine-rich domains 1
LRRC16A leucine rich repeat containing 16A
MAPRE2 microtubule-associated protein, RP/EB family, member 2
MARCH3 membrane-associated ring finger (C3HC4) 3, E3 ubiquitin protein ligase
MARCKS myristoylated alanine-rich protein kinase C substrate
MFGE8 milk fat globule-EGF factor 8 protein
MGST3 microsomal glutathione S-transferase 3
MICAL1 microtubule associated monooxygenase, calponin and LIM domain containing 1
MID1 midline 1
MMD monocyte to macrophage differentiation-associated
MMP11 matrix metallopeptidase 11
MYO1B myosin IB
MYO6 myosin VI
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NRIP1 nuclear receptor interacting protein 1
NTS neurotensin
NUCB2 nucleobindin 2
OLFM4 olfactomedin 4
OLFML2A olfactomedin-like 2A
OPN3 opsin 3
OSBPL1A oxysterol binding protein-like 1A
OSBPL8 oxysterol binding protein-like 8
OSR2 odd-skipped related transciption factor 2
PALLD palladin, cytoskeletal associated protein
PAM peptidylglycine alpha-amidating monooxygenase
PCSK5 proprotein convertase subtilisin/kexin type 5
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PLAU plasminogen activator, urokinase
PLIN2 perilipin 2
PNP purine nucleoside phosphorylase
PNRC1 proline-rich nuclear receptor coactivator 1
PPIC peptidylprolyl isomerase C (cyclophilin C)
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PROM1 prominin 1
PXDN peroxidasin
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RAB31 RAB31, member RAS oncogene family
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2
RBP1 retinol binding protein 1, cellular
RBP4 retinol binding protein 4, plasma
REEP1 receptor accessory protein 1
REG1A regenerating islet-derived 1 alpha
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
RHOBTB3 Rho-related BTB domain containing 3
RIMS3 regulating synaptic membrane exocytosis 3
RTN4 reticulon 4
RYBP RING1 and YY1 binding protein
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SDCBP syndecan binding protein (syntenin)
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SKAP2 src kinase associated phosphoprotein 2
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SOX4 SRY (sex determining region Y)-box 4
SOX9 SRY (sex determining region Y)-box 9
STMN2 stathmin 2
SYT1 synaptotagmin I
TBX3 T-box 3
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TES testin LIM domain protein
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM2 transmembrane protein 2
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TRIB2 tribbles pseudokinase 2
TRIM2 tripartite motif containing 2
TSC22D1 TSC22 domain family, member 1
TSC22D3 TSC22 domain family, member 3
TSPAN13 tetraspanin 13
TUBB2B tubulin, beta 2B class IIb
TXNIP thioredoxin interacting protein
TXNRD1 thioredoxin reductase 1
VCAN versican
VCL vinculin
VNN1 vanin 1

decreased expression

Symbol Name
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
AHCY adenosylhomocysteinase
AKT1 v-akt murine thymoma viral oncogene homolog 1
AQP3 aquaporin 3 (Gill blood group)
ATF5 activating transcription factor 5
ATP5D ATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit
B3GNT1
BAD BCL2-associated agonist of cell death
BANF1 barrier to autointegration factor 1
BDH1 3-hydroxybutyrate dehydrogenase, type 1
C1QBP complement component 1, q subcomponent binding protein
CA12 carbonic anhydrase XII
CD320 CD320 molecule
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CLU clusterin
CTBP1 C-terminal binding protein 1
DHCR24 24-dehydrocholesterol reductase
DNPH1 2'-deoxynucleoside 5'-phosphate N-hydrolase 1
DOK5 docking protein 5
EBP emopamil binding protein (sterol isomerase)
EIF5A eukaryotic translation initiation factor 5A
ELOVL1 ELOVL fatty acid elongase 1
ESR1 estrogen receptor 1
FAM57A family with sequence similarity 57, member A
FASN fatty acid synthase
FEN1 flap structure-specific endonuclease 1
FJX1 four jointed box 1 (Drosophila)
GCAT glycine C-acetyltransferase
GLOD4 glyoxalase domain containing 4
GPI glucose-6-phosphate isomerase
GRPEL1 GrpE-like 1, mitochondrial (E. coli)
GRWD1 glutamate-rich WD repeat containing 1
GSTT1 glutathione S-transferase theta 1
HIST3H2A histone cluster 3, H2a
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HN1L hematological and neurological expressed 1-like
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPE1 heat shock 10kDa protein 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IMP3 IMP3, U3 small nucleolar ribonucleoprotein
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KLK6 kallikrein-related peptidase 6
LIG1 ligase I, DNA, ATP-dependent
LONP1 lon peptidase 1, mitochondrial
LY6E lymphocyte antigen 6 complex, locus E
LYPD1 LY6/PLAUR domain containing 1
MCCC2 methylcrotonoyl-CoA carboxylase 2 (beta)
MCM2 minichromosome maintenance complex component 2
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MRPL11 mitochondrial ribosomal protein L11
MRPL12 mitochondrial ribosomal protein L12
MRPL15 mitochondrial ribosomal protein L15
MRPS12 mitochondrial ribosomal protein S12
MRPS30 mitochondrial ribosomal protein S30
MRTO4 mRNA turnover 4 homolog (S. cerevisiae)
MUC16 mucin 16, cell surface associated
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAAA N-acylethanolamine acid amidase
NCAPD3 non-SMC condensin II complex, subunit D3
NHP2 NHP2 ribonucleoprotein
NME1 NME/NM23 nucleoside diphosphate kinase 1
NME3 NME/NM23 nucleoside diphosphate kinase 3
NME4 NME/NM23 nucleoside diphosphate kinase 4
NOP16 NOP16 nucleolar protein
NUP62 nucleoporin 62kDa
OXTR oxytocin receptor
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PCNA proliferating cell nuclear antigen
PPIF peptidylprolyl isomerase F
PRR7 proline rich 7 (synaptic)
PTGDS prostaglandin D2 synthase 21kDa (brain)
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SAC3D1 SAC3 domain containing 1
SFTPA2 surfactant protein A2
SFTPC surfactant protein C
SLC19A1 solute carrier family 19 (folate transporter), member 1
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SPINK5 serine peptidase inhibitor, Kazal type 5
SRM spermidine synthase
TIMM13 translocase of inner mitochondrial membrane 13 homolog (yeast)
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TMEM97 transmembrane protein 97
TP53 tumor protein p53
TSPAN4 tetraspanin 4
TSPYL5 TSPY-like 5
WDR74 WD repeat domain 74