BRD-K35424586_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

169 genes differentially expressed following the BRD-K35424586_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ADD3 adducin 3 (gamma)
ADGRE5 adhesion G protein-coupled receptor E5
AKAP12 A kinase (PRKA) anchor protein 12
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
APOLD1 apolipoprotein L domain containing 1
ATP2A3 ATPase, Ca++ transporting, ubiquitous
ATP5S ATP synthase, H+ transporting, mitochondrial Fo complex, subunit s (factor B)
CBR3 carbonyl reductase 3
CCNG2 cyclin G2
CD47 CD47 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CFD complement factor D (adipsin)
CLDN3 claudin 3
CLDN5 claudin 5
COL6A3 collagen, type VI, alpha 3
CPA3 carboxypeptidase A3 (mast cell)
CRABP2 cellular retinoic acid binding protein 2
CRIP1 cysteine-rich protein 1 (intestinal)
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCL5 chemokine (C-X-C motif) ligand 5
CXCL6 chemokine (C-X-C motif) ligand 6
DACH1 dachshund family transcription factor 1
DCLK1 doublecortin-like kinase 1
DCN decorin
DDIT4 DNA-damage-inducible transcript 4
DHRS3 dehydrogenase/reductase (SDR family) member 3
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EDNRB endothelin receptor type B
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
ERG v-ets avian erythroblastosis virus E26 oncogene homolog
FAR2 fatty acyl CoA reductase 2
FCGBP Fc fragment of IgG binding protein
FHL1 four and a half LIM domains 1
FSD1 fibronectin type III and SPRY domain containing 1
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase)
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GDF15 growth differentiation factor 15
GLRX glutaredoxin (thioltransferase)
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GULP1 GULP, engulfment adaptor PTB domain containing 1
H1FX H1 histone family, member X
HMOX1 heme oxygenase 1
HOXB2 homeobox B2
HOXB7 homeobox B7
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPB8 heat shock 22kDa protein 8
IER3 immediate early response 3
IFI30 interferon, gamma-inducible protein 30
IL32 interleukin 32
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
KLF2 Kruppel-like factor 2
LEF1 lymphoid enhancer-binding factor 1
LGALS1 lectin, galactoside-binding, soluble, 1
LMO3 LIM domain only 3 (rhombotin-like 2)
LOXL2 lysyl oxidase-like 2
MBNL2 muscleblind-like splicing regulator 2
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MLPH melanophilin
MMD monocyte to macrophage differentiation-associated
MYH11 myosin, heavy chain 11, smooth muscle
OLFM4 olfactomedin 4
PAM peptidylglycine alpha-amidating monooxygenase
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PDZK1IP1 PDZK1 interacting protein 1
PECAM1 platelet/endothelial cell adhesion molecule 1
PERP PERP, TP53 apoptosis effector
PON2 paraoxonase 2
PPAP2C phosphatidic acid phosphatase type 2C
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform
PTGIS prostaglandin I2 (prostacyclin) synthase
RCAN1 regulator of calcineurin 1
RFX5 regulatory factor X, 5 (influences HLA class II expression)
RGS5 regulator of G-protein signaling 5
RHOB ras homolog family member B
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
S100A10 S100 calcium binding protein A10
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SCGB2A2 secretoglobin, family 2A, member 2
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC16A4 solute carrier family 16, member 4
SLC25A14 solute carrier family 25 (mitochondrial carrier, brain), member 14
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SORBS1 sorbin and SH3 domain containing 1
STC1 stanniocalcin 1
STMN2 stathmin 2
SYT1 synaptotagmin I
TAC1 tachykinin, precursor 1
TFPI2 tissue factor pathway inhibitor 2
TGFBI transforming growth factor, beta-induced, 68kDa
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TM4SF1 transmembrane 4 L six family member 1
TMEM106C transmembrane protein 106C
TPD52L1 tumor protein D52-like 1
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TSPAN7 tetraspanin 7
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UGCG UDP-glucose ceramide glucosyltransferase
VAV3 vav 3 guanine nucleotide exchange factor

decreased expression

Symbol Name
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3
ADO 2-aminoethanethiol (cysteamine) dioxygenase
ASS1 argininosuccinate synthase 1
BLCAP bladder cancer associated protein
C1ORF106 chromosome 1 open reading frame 106
C2CD2 C2 calcium-dependent domain containing 2
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCND2 cyclin D2
CD59 CD59 molecule, complement regulatory protein
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CLU clusterin
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
CXCL13 chemokine (C-X-C motif) ligand 13
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EXOSC4 exosome component 4
F3 coagulation factor III (thromboplastin, tissue factor)
FST follistatin
GFOD1 glucose-fructose oxidoreductase domain containing 1
GLUL glutamate-ammonia ligase
GRWD1 glutamate-rich WD repeat containing 1
GTPBP1 GTP binding protein 1
HBD hemoglobin, delta
HBEGF heparin-binding EGF-like growth factor
IGFBP7 insulin-like growth factor binding protein 7
IL1RN interleukin 1 receptor antagonist
IRS2 insulin receptor substrate 2
JADE2 jade family PHD finger 2
JMJD6 jumonji domain containing 6
KDM5D lysine (K)-specific demethylase 5D
KRT17 keratin 17, type I
MAP3K4 mitogen-activated protein kinase kinase kinase 4
MMP9 matrix metallopeptidase 9
MT1E metallothionein 1E
MT1X metallothionein 1X
NUP98 nucleoporin 98kDa
PDGFA platelet-derived growth factor alpha polypeptide
PDXK pyridoxal (pyridoxine, vitamin B6) kinase
PEG3 paternally expressed 3
PODXL podocalyxin-like
PPIF peptidylprolyl isomerase F
PRR5 proline rich 5 (renal)
RPL36 ribosomal protein L36
RPP38 ribonuclease P/MRP 38kDa subunit
RPS4Y1 ribosomal protein S4, Y-linked 1
RRAS2 related RAS viral (r-ras) oncogene homolog 2
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
RRP8 ribosomal RNA processing 8, methyltransferase, homolog (yeast)
RXRA retinoid X receptor, alpha
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SLC35D1 solute carrier family 35 (UDP-GlcA/UDP-GalNAc transporter), member D1
SLC52A2 solute carrier family 52 (riboflavin transporter), member 2
SMAD7 SMAD family member 7
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SPRY2 sprouty homolog 2 (Drosophila)
VSNL1 visinin-like 1
WBP5 WW domain binding protein 5
ZCCHC2 zinc finger, CCHC domain containing 2
ZNF593 zinc finger protein 593