BRD-K35128472_CC-100_PC3_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

169 genes differentially expressed following the BRD-K35128472_CC-100_PC3_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADAM28 ADAM metallopeptidase domain 28
ADD3 adducin 3 (gamma)
AKR1C3 aldo-keto reductase family 1, member C3
ANGPTL4 angiopoietin-like 4
ANPEP alanyl (membrane) aminopeptidase
ANXA4 annexin A4
AREG amphiregulin
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BCL6 B-cell CLL/lymphoma 6
BTG2 BTG family, member 2
C10ORF10 chromosome 10 open reading frame 10
CCNG2 cyclin G2
CD24 CD24 molecule
CD9 CD9 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN2A cyclin-dependent kinase inhibitor 2A
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CLDN3 claudin 3
COL4A5 collagen, type IV, alpha 5
COL4A6 collagen, type IV, alpha 6
CPA3 carboxypeptidase A3 (mast cell)
CRIP2 cysteine-rich protein 2
CTNND1 catenin (cadherin-associated protein), delta 1
DDIT4 DNA-damage-inducible transcript 4
DENND1B DENN/MADD domain containing 1B
DGKA diacylglycerol kinase, alpha 80kDa
DHRS3 dehydrogenase/reductase (SDR family) member 3
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
EPAS1 endothelial PAS domain protein 1
F11R F11 receptor
FAM69A family with sequence similarity 69, member A
FHL1 four and a half LIM domains 1
FILIP1L filamin A interacting protein 1-like
FLRT3 fibronectin leucine rich transmembrane protein 3
FRZB frizzled-related protein
FZD5 frizzled class receptor 5
GLRX glutaredoxin (thioltransferase)
GLUL glutamate-ammonia ligase
GRB10 growth factor receptor-bound protein 10
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H3H histone cluster 1, H3h
IFITM1 interferon induced transmembrane protein 1
IL1B interleukin 1, beta
IL1R1 interleukin 1 receptor, type I
IRF9 interferon regulatory factor 9
ITM2C integral membrane protein 2C
KLF9 Kruppel-like factor 9
KRT19 keratin 19, type I
KRT23 keratin 23, type I
LGALS4 lectin, galactoside-binding, soluble, 4
LITAF lipopolysaccharide-induced TNF factor
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAOA monoamine oxidase A
MAP7 microtubule-associated protein 7
MMD monocyte to macrophage differentiation-associated
MT1F metallothionein 1F
NDRG1 N-myc downstream regulated 1
NET1 neuroepithelial cell transforming 1
NT5E 5'-nucleotidase, ecto (CD73)
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PDZK1IP1 PDZK1 interacting protein 1
PID1 phosphotyrosine interaction domain containing 1
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PLAU plasminogen activator, urokinase
PLIN2 perilipin 2
PLVAP plasmalemma vesicle associated protein
PLXNB2 plexin B2
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTK2 protein tyrosine kinase 2
RAB13 RAB13, member RAS oncogene family
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RGCC regulator of cell cycle
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
SALL2 spalt-like transcription factor 2
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SH3BGRL SH3 domain binding glutamate-rich protein like
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC38A2 solute carrier family 38, member 2
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
STC1 stanniocalcin 1
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TPBG trophoblast glycoprotein
TRIB1 tribbles pseudokinase 1
TRIB2 tribbles pseudokinase 2
TXNIP thioredoxin interacting protein
UBE2L6 ubiquitin-conjugating enzyme E2L 6
VEGFA vascular endothelial growth factor A
VNN1 vanin 1
XIST X inactive specific transcript (non-protein coding)
YPEL5 yippee-like 5 (Drosophila)

decreased expression

Symbol Name
AK1 adenylate kinase 1
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
BCAT1 branched chain amino-acid transaminase 1, cytosolic
BIRC5 baculoviral IAP repeat containing 5
CCNA2 cyclin A2
CCND1 cyclin D1
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDK1 cyclin-dependent kinase 1
CDK4 cyclin-dependent kinase 4
CDKN3 cyclin-dependent kinase inhibitor 3
CENPA centromere protein A
CEP55 centrosomal protein 55kDa
CKS2 CDC28 protein kinase regulatory subunit 2
CSE1L CSE1 chromosome segregation 1-like (yeast)
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLC1 DLC1 Rho GTPase activating protein
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUSP14 dual specificity phosphatase 14
EBNA1BP2 EBNA1 binding protein 2
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FKBP11 FK506 binding protein 11, 19 kDa
FOSL1 FOS-like antigen 1
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GINS2 GINS complex subunit 2 (Psf2 homolog)
H2AFX H2A histone family, member X
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HN1 hematological and neurological expressed 1
KRT10 keratin 10, type I
KRT15 keratin 15, type I
LIPA lipase A, lysosomal acid, cholesterol esterase
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MAP2K3 mitogen-activated protein kinase kinase 3
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
NRN1 neuritin 1
NUP62 nucleoporin 62kDa
NUP98 nucleoporin 98kDa
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PBK PDZ binding kinase
PEBP1 phosphatidylethanolamine binding protein 1
PITRM1 pitrilysin metallopeptidase 1
PLK1 polo-like kinase 1
PPIF peptidylprolyl isomerase F
PRMT1 protein arginine methyltransferase 1
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
PTS 6-pyruvoyltetrahydropterin synthase
RFC2 replication factor C (activator 1) 2, 40kDa
RPL36AL ribosomal protein L36a-like
RPP40 ribonuclease P/MRP 40kDa subunit
RRM1 ribonucleotide reductase M1
SACS sacsin molecular chaperone
SHCBP1 SHC SH2-domain binding protein 1
SLIRP SRA stem-loop interacting RNA binding protein
SLIT2 slit homolog 2 (Drosophila)
SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa
SRM spermidine synthase
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TACC3 transforming, acidic coiled-coil containing protein 3
TIMM13 translocase of inner mitochondrial membrane 13 homolog (yeast)
TNPO1 transportin 1
TOP2A topoisomerase (DNA) II alpha 170kDa
TRIP13 thyroid hormone receptor interactor 13
TSPYL5 TSPY-like 5
TYMS thymidylate synthetase
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
UBE2E3 ubiquitin-conjugating enzyme E2E 3
UBE2S ubiquitin-conjugating enzyme E2S