BRD-K34363599_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

124 genes differentially expressed following the BRD-K34363599_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ANGPTL2 angiopoietin-like 2
AQP3 aquaporin 3 (Gill blood group)
AREG amphiregulin
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARID5B AT rich interactive domain 5B (MRF1-like)
ARL4C ADP-ribosylation factor-like 4C
ARMCX1 armadillo repeat containing, X-linked 1
ARMCX2 armadillo repeat containing, X-linked 2
ATF3 activating transcription factor 3
CCNA1 cyclin A1
CD40 CD40 molecule, TNF receptor superfamily member 5
CD9 CD9 molecule
CELF2 CUGBP, Elav-like family member 2
CLEC2B C-type lectin domain family 2, member B
CRABP1 cellular retinoic acid binding protein 1
CSRP2 cysteine and glycine-rich protein 2
CXCL8 chemokine (C-X-C motif) ligand 8
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DKK3 dickkopf WNT signaling pathway inhibitor 3
DUSP6 dual specificity phosphatase 6
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EGR1 early growth response 1
EGR3 early growth response 3
EMP1 epithelial membrane protein 1
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FABP4 fatty acid binding protein 4, adipocyte
FAM107A family with sequence similarity 107, member A
FAM129A family with sequence similarity 129, member A
FBXL12 F-box and leucine-rich repeat protein 12
GEM GTP binding protein overexpressed in skeletal muscle
GOLT1B golgi transport 1B
GPNMB glycoprotein (transmembrane) nmb
GRB10 growth factor receptor-bound protein 10
GREM1 gremlin 1, DAN family BMP antagonist
GYPC glycophorin C (Gerbich blood group)
HBEGF heparin-binding EGF-like growth factor
HBP1 HMG-box transcription factor 1
HES1 hes family bHLH transcription factor 1
IDO1 indoleamine 2,3-dioxygenase 1
IER3 immediate early response 3
IGFBP5 insulin-like growth factor binding protein 5
IGHM immunoglobulin heavy constant mu
IGLL3P immunoglobulin lambda-like polypeptide 3, pseudogene
IL7R interleukin 7 receptor
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
JCHAIN joining chain of multimeric IgA and IgM
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
KRT13 keratin 13, type I
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
LY96 lymphocyte antigen 96
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MBNL2 muscleblind-like splicing regulator 2
MECOM MDS1 and EVI1 complex locus
MEIS1 Meis homeobox 1
MEIS2 Meis homeobox 2
MME membrane metallo-endopeptidase
NAV2 neuron navigator 2
NFE2L2 nuclear factor, erythroid 2-like 2
NMRK1 nicotinamide riboside kinase 1
NQO1 NAD(P)H dehydrogenase, quinone 1
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A3 nuclear receptor subfamily 4, group A, member 3
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
PHLDA1 pleckstrin homology-like domain, family A, member 1
PTN pleiotrophin
RND3 Rho family GTPase 3
RRAGD Ras-related GTP binding D
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFRP1 secreted frizzled-related protein 1
SMAD3 SMAD family member 3
SOCS2 suppressor of cytokine signaling 2
SPRR3 small proline-rich protein 3
SQSTM1 sequestosome 1
STC1 stanniocalcin 1
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
THBS1 thrombospondin 1
TIMP2 TIMP metallopeptidase inhibitor 2
TRIM2 tripartite motif containing 2
WARS tryptophanyl-tRNA synthetase
WIPI1 WD repeat domain, phosphoinositide interacting 1
XIST X inactive specific transcript (non-protein coding)
ZFP36 ZFP36 ring finger protein
ZFP36L1 ZFP36 ring finger protein-like 1

decreased expression

Symbol Name
ACAT2 acetyl-CoA acetyltransferase 2
AP2B1 adaptor-related protein complex 2, beta 1 subunit
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1
ASCL1 achaete-scute family bHLH transcription factor 1
CLU clusterin
CST3 cystatin C
DCN decorin
DDB2 damage-specific DNA binding protein 2, 48kDa
DHRS11 dehydrogenase/reductase (SDR family) member 11
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EIF4B eukaryotic translation initiation factor 4B
FASTKD5 FAST kinase domains 5
HEXIM1 hexamethylene bis-acetamide inducible 1
HSPA1A heat shock 70kDa protein 1A
ITGB1BP1 integrin beta 1 binding protein 1
KBTBD11 kelch repeat and BTB (POZ) domain containing 11
KDM5D lysine (K)-specific demethylase 5D
KIF20A kinesin family member 20A
MAP7 microtubule-associated protein 7
METRN meteorin, glial cell differentiation regulator
NDRG3 NDRG family member 3
NME4 NME/NM23 nucleoside diphosphate kinase 4
NNMT nicotinamide N-methyltransferase
NPY neuropeptide Y
NUP62 nucleoporin 62kDa
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta
PRKCA protein kinase C, alpha
QPCT glutaminyl-peptide cyclotransferase
SLC25A15 solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15
SLC39A6 solute carrier family 39 (zinc transporter), member 6
TIMM13 translocase of inner mitochondrial membrane 13 homolog (yeast)
TLR4 toll-like receptor 4
TMEM14A transmembrane protein 14A
TRAPPC3 trafficking protein particle complex 3
VCAN versican