BRD-K34014345_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

113 genes differentially expressed following the BRD-K34014345_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ALCAM activated leukocyte cell adhesion molecule
APOD apolipoprotein D
AQP3 aquaporin 3 (Gill blood group)
BANK1 B-cell scaffold protein with ankyrin repeats 1
C7 complement component 7
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CCL19 chemokine (C-C motif) ligand 19
CCR7 chemokine (C-C motif) receptor 7
CD59 CD59 molecule, complement regulatory protein
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
COBL cordon-bleu WH2 repeat protein
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CYBA cytochrome b-245, alpha polypeptide
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
FNDC3B fibronectin type III domain containing 3B
HOPX HOP homeobox
HOXC6 homeobox C6
HSPA1A heat shock 70kDa protein 1A
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
IGFBP4 insulin-like growth factor binding protein 4
IGHM immunoglobulin heavy constant mu
IL6ST interleukin 6 signal transducer
KIAA1033 KIAA1033
KRT7 keratin 7, type II
LAMP5 lysosomal-associated membrane protein family, member 5
LPL lipoprotein lipase
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MAP7 microtubule-associated protein 7
MGLL monoglyceride lipase
NME4 NME/NM23 nucleoside diphosphate kinase 4
PMP2 peripheral myelin protein 2
PPARG peroxisome proliferator-activated receptor gamma
RDX radixin
RHOBTB3 Rho-related BTB domain containing 3
RPS11 ribosomal protein S11
RRP8 ribosomal RNA processing 8, methyltransferase, homolog (yeast)
S100B S100 calcium binding protein B
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SFRP1 secreted frizzled-related protein 1
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SRPX sushi-repeat containing protein, X-linked
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
TBX3 T-box 3
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TGFBI transforming growth factor, beta-induced, 68kDa
TNC tenascin C
TRIB2 tribbles pseudokinase 2
TSC22D1 TSC22 domain family, member 1
TSPAN13 tetraspanin 13
TSPAN8 tetraspanin 8
WNT5A wingless-type MMTV integration site family, member 5A

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACAT2 acetyl-CoA acetyltransferase 2
ADIRF adipogenesis regulatory factor
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
ASPN asporin
ASS1 argininosuccinate synthase 1
BCAM basal cell adhesion molecule (Lutheran blood group)
BCHE butyrylcholinesterase
CAP2 CAP, adenylate cyclase-associated protein, 2 (yeast)
CCL20 chemokine (C-C motif) ligand 20
CCL4 chemokine (C-C motif) ligand 4
CCL5 chemokine (C-C motif) ligand 5
CD200 CD200 molecule
CD24 CD24 molecule
CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7
COL6A1 collagen, type VI, alpha 1
COL8A2 collagen, type VIII, alpha 2
CP ceruloplasmin (ferroxidase)
CPE carboxypeptidase E
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCL10 chemokine (C-X-C motif) ligand 10
DACH1 dachshund family transcription factor 1
DEFB1 defensin, beta 1
DHCR24 24-dehydrocholesterol reductase
ESR1 estrogen receptor 1
FGFR1 fibroblast growth factor receptor 1
GBP1 guanylate binding protein 1, interferon-inducible
GJA1 gap junction protein, alpha 1, 43kDa
GLUL glutamate-ammonia ligase
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
IFI27 interferon, alpha-inducible protein 27
KRAS Kirsten rat sarcoma viral oncogene homolog
LRRC17 leucine rich repeat containing 17
LYPD1 LY6/PLAUR domain containing 1
MNDA myeloid cell nuclear differentiation antigen
MX1 MX dynamin-like GTPase 1
NCF2 neutrophil cytosolic factor 2
NREP neuronal regeneration related protein
NRIP1 nuclear receptor interacting protein 1
PEG10 paternally expressed 10
PI3 peptidase inhibitor 3, skin-derived
PLEKHM1 pleckstrin homology domain containing, family M (with RUN domain) member 1
PLK2 polo-like kinase 2
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform
PRUNE2 prune homolog 2 (Drosophila)
RGCC regulator of cell cycle
RGS1 regulator of G-protein signaling 1
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SNX7 sorting nexin 7
SQLE squalene epoxidase
STC2 stanniocalcin 2
SULF1 sulfatase 1
TMEM45A transmembrane protein 45A
TWIST1 twist family bHLH transcription factor 1
WARS tryptophanyl-tRNA synthetase