BRD-K33882852_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

108 genes differentially expressed following the BRD-K33882852_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD6 abhydrolase domain containing 6
ANXA1 annexin A1
AREG amphiregulin
ASNS asparagine synthetase (glutamine-hydrolyzing)
CD47 CD47 molecule
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHI3L2 chitinase 3-like 2
CLC Charcot-Leyden crystal galectin
COTL1 coactosin-like F-actin binding protein 1
CREG1 cellular repressor of E1A-stimulated genes 1
CSTA cystatin A (stefin A)
CTSZ cathepsin Z
CXCL8 chemokine (C-X-C motif) ligand 8
CYBA cytochrome b-245, alpha polypeptide
DDIT4 DNA-damage-inducible transcript 4
DUSP1 dual specificity phosphatase 1
EREG epiregulin
FTH1 ferritin, heavy polypeptide 1
GDF15 growth differentiation factor 15
IARS isoleucyl-tRNA synthetase
IFITM1 interferon induced transmembrane protein 1
IFITM2 interferon induced transmembrane protein 2
IFITM3 interferon induced transmembrane protein 3
ITM2A integral membrane protein 2A
KLF6 Kruppel-like factor 6
KYNU kynureninase
LCN2 lipocalin 2
LMO2 LIM domain only 2 (rhombotin-like 1)
LXN latexin
LY6D lymphocyte antigen 6 complex, locus D
MAP7 microtubule-associated protein 7
MBNL2 muscleblind-like splicing regulator 2
MET MET proto-oncogene, receptor tyrosine kinase
MKNK2 MAP kinase interacting serine/threonine kinase 2
MPO myeloperoxidase
NAMPT nicotinamide phosphoribosyltransferase
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NMU neuromedin U
NRN1 neuritin 1
PCP4 Purkinje cell protein 4
PDLIM1 PDZ and LIM domain 1
PERP PERP, TP53 apoptosis effector
PLIN3 perilipin 3
PSAP prosaposin
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RGS2 regulator of G-protein signaling 2
S100A12 S100 calcium binding protein A12
S100A7 S100 calcium binding protein A7
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SELL selectin L
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC25A14 solute carrier family 25 (mitochondrial carrier, brain), member 14
SLC38A1 solute carrier family 38, member 1
SOD2 superoxide dismutase 2, mitochondrial
SORD sorbitol dehydrogenase
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
STC2 stanniocalcin 2
TBC1D31 TBC1 domain family, member 31
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TMEM176B transmembrane protein 176B
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TRBC1 T cell receptor beta constant 1
UBE2L6 ubiquitin-conjugating enzyme E2L 6
ZFAND5 zinc finger, AN1-type domain 5
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ADGRL2 adhesion G protein-coupled receptor L2
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ASPN asporin
CADM1 cell adhesion molecule 1
CDC25A cell division cycle 25A
COL10A1 collagen, type X, alpha 1
COL11A1 collagen, type XI, alpha 1
DPT dermatopontin
FBXL12 F-box and leucine-rich repeat protein 12
GAB2 GRB2-associated binding protein 2
GRWD1 glutamate-rich WD repeat containing 1
HNMT histamine N-methyltransferase
IGF1 insulin-like growth factor 1 (somatomedin C)
LPAR6 lysophosphatidic acid receptor 6
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
MECOM MDS1 and EVI1 complex locus
MFAP5 microfibrillar associated protein 5
MSLN mesothelin
MX2 MX dynamin-like GTPase 2
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NCAPD2 non-SMC condensin I complex, subunit D2
NID1 nidogen 1
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae)
PAPD7 PAP associated domain containing 7
PEG10 paternally expressed 10
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PLEKHM1 pleckstrin homology domain containing, family M (with RUN domain) member 1
PLLP plasmolipin
PMM2 phosphomannomutase 2
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SNX7 sorting nexin 7
SPINK1 serine peptidase inhibitor, Kazal type 1
SPON1 spondin 1, extracellular matrix protein
TWIST1 twist family bHLH transcription factor 1