BRD-K33551950_R2146_VCAP_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

124 genes differentially expressed following the BRD-K33551950_R2146_VCAP_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ABHD4 abhydrolase domain containing 4
AKAP9 A kinase (PRKA) anchor protein 9
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ANKRD12 ankyrin repeat domain 12
ANXA1 annexin A1
ANXA2 annexin A2
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BAG3 BCL2-associated athanogene 3
BAMBI BMP and activin membrane-bound inhibitor
CACYBP calcyclin binding protein
CBR1 carbonyl reductase 1
CBS cystathionine-beta-synthase
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHMP1B charged multivesicular body protein 1B
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CLIC4 chloride intracellular channel 4
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DDIT3 DNA-damage-inducible transcript 3
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DSG2 desmoglein 2
DSP desmoplakin
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
EPRS glutamyl-prolyl-tRNA synthetase
FGG fibrinogen gamma chain
GCLC glutamate-cysteine ligase, catalytic subunit
GCLM glutamate-cysteine ligase, modifier subunit
GRB10 growth factor receptor-bound protein 10
HBP1 HMG-box transcription factor 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMOX1 heme oxygenase 1
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA13 heat shock protein 70kDa family, member 13
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPE1 heat shock 10kDa protein 1
HSPH1 heat shock 105kDa/110kDa protein 1
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
IARS isoleucyl-tRNA synthetase
IFRD1 interferon-related developmental regulator 1
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
JMJD6 jumonji domain containing 6
MAP7 microtubule-associated protein 7
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NQO1 NAD(P)H dehydrogenase, quinone 1
NRIP1 nuclear receptor interacting protein 1
NUPR1 nuclear protein, transcriptional regulator, 1
ODC1 ornithine decarboxylase 1
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDIA6 protein disulfide isomerase family A, member 6
PERP PERP, TP53 apoptosis effector
PKD1P1 polycystic kidney disease 1 (autosomal dominant) pseudogene 1
PRDX1 peroxiredoxin 1
PSAT1 phosphoserine aminotransferase 1
RIOK3 RIO kinase 3
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SLC35B1 solute carrier family 35, member B1
SLC38A1 solute carrier family 38, member 1
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SPATS2L spermatogenesis associated, serine-rich 2-like
STK26 serine/threonine protein kinase 26
TARS threonyl-tRNA synthetase
TGIF1 TGFB-induced factor homeobox 1
TMEM2 transmembrane protein 2
TMEM97 transmembrane protein 97
TPBG trophoblast glycoprotein
TXNRD1 thioredoxin reductase 1
UGDH UDP-glucose 6-dehydrogenase
WARS tryptophanyl-tRNA synthetase
WSB1 WD repeat and SOCS box containing 1
XBP1 X-box binding protein 1
YARS tyrosyl-tRNA synthetase

decreased expression

Symbol Name
ADGRF5 adhesion G protein-coupled receptor F5
AIM1 absent in melanoma 1
B3GNT1
C14ORF159 chromosome 14 open reading frame 159
CCDC85B coiled-coil domain containing 85B
CCND1 cyclin D1
CHRDL1 chordin-like 1
CKB creatine kinase, brain
CRIP2 cysteine-rich protein 2
FBLN1 fibulin 1
FEN1 flap structure-specific endonuclease 1
HOXA10 homeobox A10
IGF1 insulin-like growth factor 1 (somatomedin C)
LRRC17 leucine rich repeat containing 17
MTA1 metastasis associated 1
MYH11 myosin, heavy chain 11, smooth muscle
PLAT plasminogen activator, tissue
PPIF peptidylprolyl isomerase F
PRKCD protein kinase C, delta
PRR7 proline rich 7 (synaptic)
PTGDS prostaglandin D2 synthase 21kDa (brain)
RAP1GAP RAP1 GTPase activating protein
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RBP1 retinol binding protein 1, cellular
RFC3 replication factor C (activator 1) 3, 38kDa
SPDEF SAM pointed domain containing ETS transcription factor
TKTL1 transketolase-like 1
TMEM109 transmembrane protein 109