BRD-K33551950_R2146_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

269 genes differentially expressed following the BRD-K33551950_R2146_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5
ABHD4 abhydrolase domain containing 4
ACSL3 acyl-CoA synthetase long-chain family member 3
ADM adrenomedullin
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ALDOC aldolase C, fructose-bisphosphate
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
BCAP31 B-cell receptor-associated protein 31
BMP7 bone morphogenetic protein 7
BRD2 bromodomain containing 2
BRD4 bromodomain containing 4
CA2 carbonic anhydrase II
CBR3 carbonyl reductase 3
CCND3 cyclin D3
CD24 CD24 molecule
CHPF2 chondroitin polymerizing factor 2
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11
CKAP4 cytoskeleton-associated protein 4
CLEC3B C-type lectin domain family 3, member B
CLU clusterin
CNOT4 CCR4-NOT transcription complex, subunit 4
COL4A5 collagen, type IV, alpha 5
CRABP1 cellular retinoic acid binding protein 1
CREB3L2 cAMP responsive element binding protein 3-like 2
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CUX1 cut-like homeobox 1
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
EFHD1 EF-hand domain family, member D1
EPAS1 endothelial PAS domain protein 1
EPCAM epithelial cell adhesion molecule
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FADS2 fatty acid desaturase 2
FAM117A family with sequence similarity 117, member A
FAM129A family with sequence similarity 129, member A
FASTKD5 FAST kinase domains 5
FN1 fibronectin 1
FOSL1 FOS-like antigen 1
FTH1 ferritin, heavy polypeptide 1
G6PD glucose-6-phosphate dehydrogenase
GABARAPL1 GABA(A) receptor-associated protein like 1
GABRE gamma-aminobutyric acid (GABA) A receptor, epsilon
GADD45A growth arrest and DNA-damage-inducible, alpha
GCLC glutamate-cysteine ligase, catalytic subunit
GCLM glutamate-cysteine ligase, modifier subunit
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GULP1 GULP, engulfment adaptor PTB domain containing 1
HBB hemoglobin, beta
HBD hemoglobin, delta
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIC2 hypermethylated in cancer 2
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA1A heat shock 70kDa protein 1A
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
IDS iduronate 2-sulfatase
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGFBP5 insulin-like growth factor binding protein 5
INSR insulin receptor
JAG1 jagged 1
KDM3A lysine (K)-specific demethylase 3A
KRT6A keratin 6A, type II
LAMP1 lysosomal-associated membrane protein 1
LBH limb bud and heart development
LIPG lipase, endothelial
LPIN1 lipin 1
MAFG v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G
MAP1A microtubule-associated protein 1A
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MAP7 microtubule-associated protein 7
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MFAP5 microfibrillar associated protein 5
MIR22HG MIR22 host gene
MKNK2 MAP kinase interacting serine/threonine kinase 2
MSMO1 methylsterol monooxygenase 1
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NPTX2 neuronal pentraxin II
NSDHL NAD(P) dependent steroid dehydrogenase-like
OSBPL2 oxysterol binding protein-like 2
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PCDH17 protocadherin 17
PCDH9 protocadherin 9
PRNP prion protein
PSAP prosaposin
PSME4 proteasome (prosome, macropain) activator subunit 4
PTHLH parathyroid hormone-like hormone
QPRT quinolinate phosphoribosyltransferase
RABEP2 rabaptin, RAB GTPase binding effector protein 2
RGCC regulator of cell cycle
RIOK3 RIO kinase 3
RIT1 Ras-like without CAAX 1
RNF24 ring finger protein 24
RRBP1 ribosome binding protein 1
SAT1 spermidine/spermine N1-acetyltransferase 1
SCPEP1 serine carboxypeptidase 1
SEC14L1 SEC14-like 1 (S. cerevisiae)
SEC62 SEC62 homolog (S. cerevisiae)
SERTAD2 SERTA domain containing 2
SIK3 SIK family kinase 3
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SON SON DNA binding protein
SPAG9 sperm associated antigen 9
SQLE squalene epoxidase
SQSTM1 sequestosome 1
STC1 stanniocalcin 1
STX1A syntaxin 1A (brain)
TGM2 transglutaminase 2
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM41B transmembrane protein 41B
TOP1 topoisomerase (DNA) I
TUBB2A tubulin, beta 2A class IIa
TXNL4B thioredoxin-like 4B
TXNRD1 thioredoxin reductase 1
USP47 ubiquitin specific peptidase 47
XIST X inactive specific transcript (non-protein coding)
YPEL5 yippee-like 5 (Drosophila)
ZNF12 zinc finger protein 12

decreased expression

Symbol Name
ABLIM1 actin binding LIM protein 1
ACSL5 acyl-CoA synthetase long-chain family member 5
ACTN1 actinin, alpha 1
ADD3 adducin 3 (gamma)
AGR2 anterior gradient 2
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
ARMCX2 armadillo repeat containing, X-linked 2
ARMT1 acidic residue methyltransferase 1
ASF1B anti-silencing function 1B histone chaperone
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATP5S ATP synthase, H+ transporting, mitochondrial Fo complex, subunit s (factor B)
BASP1 brain abundant, membrane attached signal protein 1
BDH1 3-hydroxybutyrate dehydrogenase, type 1
BIRC5 baculoviral IAP repeat containing 5
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C1QBP complement component 1, q subcomponent binding protein
C2CD5 C2 calcium-dependent domain containing 5
C3 complement component 3
C7 complement component 7
CCNA2 cyclin A2
CCNB2 cyclin B2
CCNF cyclin F
CDC20 cell division cycle 20
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDC45 cell division cycle 45
CDK1 cyclin-dependent kinase 1
CDK4 cyclin-dependent kinase 4
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CDKN3 cyclin-dependent kinase inhibitor 3
CELF2 CUGBP, Elav-like family member 2
CENPA centromere protein A
CEP55 centrosomal protein 55kDa
CFB complement factor B
CFI complement factor I
COA1 cytochrome c oxidase assembly factor 1 homolog (S. cerevisiae)
CP ceruloplasmin (ferroxidase)
CXCL12 chemokine (C-X-C motif) ligand 12
DHFR dihydrofolate reductase
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNPH1 2'-deoxynucleoside 5'-phosphate N-hydrolase 1
DUT deoxyuridine triphosphatase
DYRK4 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4
EIF5A eukaryotic translation initiation factor 5A
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
ELP5 elongator acetyltransferase complex subunit 5
ESR1 estrogen receptor 1
FAM216A family with sequence similarity 216, member A
FKBP3 FK506 binding protein 3, 25kDa
FOLR1 folate receptor 1 (adult)
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GINS1 GINS complex subunit 1 (Psf1 homolog)
GJA1 gap junction protein, alpha 1, 43kDa
HAUS4 HAUS augmin-like complex, subunit 4
HMGB2 high mobility group box 2
HMMR hyaluronan-mediated motility receptor (RHAMM)
HNMT histamine N-methyltransferase
IFITM2 interferon induced transmembrane protein 2
IFITM3 interferon induced transmembrane protein 3
IGFBP7 insulin-like growth factor binding protein 7
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
IPO4 importin 4
ITGB3BP integrin beta 3 binding protein (beta3-endonexin)
KIAA0101 KIAA0101
KIF14 kinesin family member 14
KIF20A kinesin family member 20A
KIF2C kinesin family member 2C
LAPTM4B lysosomal protein transmembrane 4 beta
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LIG1 ligase I, DNA, ATP-dependent
LMNB1 lamin B1
LSM2 LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LYPLA1 lysophospholipase I
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MARCKS myristoylated alanine-rich protein kinase C substrate
MAT2B methionine adenosyltransferase II, beta
MELK maternal embryonic leucine zipper kinase
MRPL15 mitochondrial ribosomal protein L15
MUC16 mucin 16, cell surface associated
MYB v-myb avian myeloblastosis viral oncogene homolog
NBN nibrin
NEK2 NIMA-related kinase 2
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NHP2 NHP2 ribonucleoprotein
NMU neuromedin U
NR2F1 nuclear receptor subfamily 2, group F, member 1
NR2F2 nuclear receptor subfamily 2, group F, member 2
NREP neuronal regeneration related protein
NRIP1 nuclear receptor interacting protein 1
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)
PBK PDZ binding kinase
PLK1 polo-like kinase 1
PLK4 polo-like kinase 4
PLS1 plastin 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PSPH phosphoserine phosphatase
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTTG1 pituitary tumor-transforming 1
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RBM3 RNA binding motif (RNP1, RRM) protein 3
RFC3 replication factor C (activator 1) 3, 38kDa
RGS1 regulator of G-protein signaling 1
RGS10 regulator of G-protein signaling 10
RHOBTB3 Rho-related BTB domain containing 3
RMND1 required for meiotic nuclear division 1 homolog (S. cerevisiae)
RNASE4 ribonuclease, RNase A family, 4
RNASEH2A ribonuclease H2, subunit A
RPIA ribose 5-phosphate isomerase A
SDHAF3 succinate dehydrogenase complex assembly factor 3
SPC25 SPC25, NDC80 kinetochore complex component
SPDEF SAM pointed domain containing ETS transcription factor
SPDL1 spindle apparatus coiled-coil protein 1
SRSF7 serine/arginine-rich splicing factor 7
STMN1 stathmin 1
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
TACSTD2 tumor-associated calcium signal transducer 2
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
TFPI2 tissue factor pathway inhibitor 2
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TMEM126B transmembrane protein 126B
TMEM176A transmembrane protein 176A
TMEM251 transmembrane protein 251
TMPO thymopoietin
TOP2A topoisomerase (DNA) II alpha 170kDa
TOX thymocyte selection-associated high mobility group box
TPX2 TPX2, microtubule-associated
TRIP6 thyroid hormone receptor interactor 6
TRMT5 tRNA methyltransferase 5
TSEN2 TSEN2 tRNA splicing endonuclease subunit
TSPAN6 tetraspanin 6
TUSC3 tumor suppressor candidate 3
TYMS thymidylate synthetase
TYRP1 tyrosinase-related protein 1
UBE2C ubiquitin-conjugating enzyme E2C
VRK1 vaccinia related kinase 1
WFDC2 WAP four-disulfide core domain 2
XBP1 X-box binding protein 1
ZBTB20 zinc finger and BTB domain containing 20
ZNF22 zinc finger protein 22
ZWINT ZW10 interacting kinetochore protein