BRD-K33379087_tivantinib_MCF7_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

228 genes differentially expressed following the BRD-K33379087_tivantinib_MCF7_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACTC1 actin, alpha, cardiac muscle 1
ADGRG2 adhesion G protein-coupled receptor G2
AIM1 absent in melanoma 1
AKAP8L A kinase (PRKA) anchor protein 8-like
ALAS2 5'-aminolevulinate synthase 2
ASS1 argininosuccinate synthase 1
AURKA aurora kinase A
AUTS2 autism susceptibility candidate 2
BAG2 BCL2-associated athanogene 2
BIK BCL2-interacting killer (apoptosis-inducing)
CAPN2 calpain 2, (m/II) large subunit
CAV2 caveolin 2
CCL5 chemokine (C-C motif) ligand 5
CCND2 cyclin D2
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLEC11A C-type lectin domain family 11, member A
CNR1 cannabinoid receptor 1 (brain)
COCH cochlin
COL18A1 collagen, type XVIII, alpha 1
CP ceruloplasmin (ferroxidase)
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
CSRP2 cysteine and glycine-rich protein 2
CTGF connective tissue growth factor
CXCL8 chemokine (C-X-C motif) ligand 8
CYR61 cysteine-rich, angiogenic inducer, 61
DKK1 dickkopf WNT signaling pathway inhibitor 1
DKK3 dickkopf WNT signaling pathway inhibitor 3
EGR1 early growth response 1
F13A1 coagulation factor XIII, A1 polypeptide
FGF13 fibroblast growth factor 13
FGF9 fibroblast growth factor 9
FOSL1 FOS-like antigen 1
FSTL1 follistatin-like 1
GPM6A glycoprotein M6A
H2BFS H2B histone family, member S (pseudogene)
H3F3B H3 histone, family 3B (H3.3B)
HBD hemoglobin, delta
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BC histone cluster 1, H2bc
HIST1H2BD histone cluster 1, H2bd
HIST1H2BE histone cluster 1, H2be
HIST1H2BF histone cluster 1, H2bf
HIST1H2BG histone cluster 1, H2bg
HIST1H3H histone cluster 1, H3h
HIST2H2BE histone cluster 2, H2be
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
IGHM immunoglobulin heavy constant mu
IL7R interleukin 7 receptor
INHBB inhibin, beta B
KIF20A kinesin family member 20A
LCN2 lipocalin 2
LDLR low density lipoprotein receptor
LGALS4 lectin, galactoside-binding, soluble, 4
MAOB monoamine oxidase B
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1X metallothionein 1X
NACC2 NACC family member 2, BEN and BTB (POZ) domain containing
NCF1C neutrophil cytosolic factor 1C pseudogene
NELL2 NEL-like 2 (chicken)
NOSIP nitric oxide synthase interacting protein
NPTX2 neuronal pentraxin II
NTS neurotensin
OBSL1 obscurin-like 1
PCDH9 protocadherin 9
PCSK6 proprotein convertase subtilisin/kexin type 6
PDIA3 protein disulfide isomerase family A, member 3
PHLDA1 pleckstrin homology-like domain, family A, member 1
PIEZO1 piezo-type mechanosensitive ion channel component 1
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLK2 polo-like kinase 2
PODXL podocalyxin-like
PPA1 pyrophosphatase (inorganic) 1
PPIC peptidylprolyl isomerase C (cyclophilin C)
PRR7 proline rich 7 (synaptic)
PSMD9 proteasome (prosome, macropain) 26S subunit, non-ATPase, 9
PTX3 pentraxin 3, long
RABEP2 rabaptin, RAB GTPase binding effector protein 2
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RNF11 ring finger protein 11
S100A12 S100 calcium binding protein A12
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SACM1L SAC1 suppressor of actin mutations 1-like (yeast)
SAP18 Sin3A-associated protein, 18kDa
SCYL3 SCY1-like 3 (S. cerevisiae)
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLPI secretory leukocyte peptidase inhibitor
SNRPF small nuclear ribonucleoprotein polypeptide F
TCL1A T-cell leukemia/lymphoma 1A
TGFBI transforming growth factor, beta-induced, 68kDa
TIMP1 TIMP metallopeptidase inhibitor 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TPM1 tropomyosin 1 (alpha)
TSPAN8 tetraspanin 8
TUBB2A tubulin, beta 2A class IIa
TUBB2B tubulin, beta 2B class IIb
UBE2S ubiquitin-conjugating enzyme E2S
UPF3A UPF3 regulator of nonsense transcripts homolog A (yeast)
ZDHHC11 zinc finger, DHHC-type containing 11
ZIC1 Zic family member 1
ZMYND8 zinc finger, MYND-type containing 8
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
AHR aryl hydrocarbon receptor
AKR1C3 aldo-keto reductase family 1, member C3
ALOX15B arachidonate 15-lipoxygenase, type B
APOC1 apolipoprotein C-I
AQP1 aquaporin 1 (Colton blood group)
ARMCX3 armadillo repeat containing, X-linked 3
ATAD2 ATPase family, AAA domain containing 2
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5
BET1 Bet1 golgi vesicular membrane trafficking protein
BEX4 brain expressed, X-linked 4
BHLHE41 basic helix-loop-helix family, member e41
C10ORF10 chromosome 10 open reading frame 10
CCDC86 coiled-coil domain containing 86
CCNE2 cyclin E2
CCNF cyclin F
CD24 CD24 molecule
CDCA4 cell division cycle associated 4
CDK1 cyclin-dependent kinase 1
CDK2 cyclin-dependent kinase 2
CHEK2 checkpoint kinase 2
CLDN3 claudin 3
COPS7A COP9 signalosome subunit 7A
CRTAP cartilage associated protein
CTSK cathepsin K
CXCL14 chemokine (C-X-C motif) ligand 14
DEPTOR DEP domain containing MTOR-interacting protein
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DPT dermatopontin
DSP desmoplakin
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EAPP E2F-associated phosphoprotein
EFR3A EFR3 homolog A (S. cerevisiae)
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2
ELAVL4 ELAV like neuron-specific RNA binding protein 4
ESR1 estrogen receptor 1
FANCI Fanconi anemia, complementation group I
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)
FMO5 flavin containing monooxygenase 5
FOXG1 forkhead box G1
GATA3 GATA binding protein 3
GINS1 GINS complex subunit 1 (Psf1 homolog)
GLS glutaminase
GNPDA1 glucosamine-6-phosphate deaminase 1
GPNMB glycoprotein (transmembrane) nmb
HADH hydroxyacyl-CoA dehydrogenase
HES1 hes family bHLH transcription factor 1
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA1A heat shock 70kDa protein 1A
IFI27 interferon, alpha-inducible protein 27
IFI44L interferon-induced protein 44-like
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFITM1 interferon induced transmembrane protein 1
IGF1R insulin-like growth factor 1 receptor
IL1R1 interleukin 1 receptor, type I
ISG15 ISG15 ubiquitin-like modifier
KIAA0101 KIAA0101
KRT15 keratin 15, type I
LOC100505650 uncharacterized LOC100505650
LXN latexin
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAP2K6 mitogen-activated protein kinase kinase 6
MBP myelin basic protein
MCM6 minichromosome maintenance complex component 6
MELK maternal embryonic leucine zipper kinase
MFAP5 microfibrillar associated protein 5
MFSD10 major facilitator superfamily domain containing 10
MMP12 matrix metallopeptidase 12
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MUC16 mucin 16, cell surface associated
MX1 MX dynamin-like GTPase 1
MXRA5 matrix-remodelling associated 5
MYBPC1 myosin binding protein C, slow type
MYH10 myosin, heavy chain 10, non-muscle
NCAPD3 non-SMC condensin II complex, subunit D3
NET1 neuroepithelial cell transforming 1
NFIB nuclear factor I/B
NKX2-1 NK2 homeobox 1
NLRP2 NLR family, pyrin domain containing 2
NR1H2 nuclear receptor subfamily 1, group H, member 2
NR2F2 nuclear receptor subfamily 2, group F, member 2
NUSAP1 nucleolar and spindle associated protein 1
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
PACSIN3 protein kinase C and casein kinase substrate in neurons 3
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDGFRL platelet-derived growth factor receptor-like
PLEKHA5 pleckstrin homology domain containing, family A member 5
PTPRO protein tyrosine phosphatase, receptor type, O
QPCT glutaminyl-peptide cyclotransferase
RAD51AP1 RAD51 associated protein 1
RNASE4 ribonuclease, RNase A family, 4
RNF38 ring finger protein 38
RRM2 ribonucleotide reductase M2
RSAD2 radical S-adenosyl methionine domain containing 2
S100A14 S100 calcium binding protein A14
SCGB2A1 secretoglobin, family 2A, member 1
SLC26A3 solute carrier family 26 (anion exchanger), member 3
SMAD1 SMAD family member 1
SSPN sarcospan
STAT1 signal transducer and activator of transcription 1, 91kDa
STXBP2 syntaxin binding protein 2
SULF1 sulfatase 1
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
TFPI2 tissue factor pathway inhibitor 2
TMED10 transmembrane emp24-like trafficking protein 10 (yeast)
TMEM243 transmembrane protein 243, mitochondrial
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TOP2A topoisomerase (DNA) II alpha 170kDa
TOPBP1 topoisomerase (DNA) II binding protein 1
TPD52L1 tumor protein D52-like 1
TSPAN13 tetraspanin 13
TUSC3 tumor suppressor candidate 3
TXNDC9 thioredoxin domain containing 9
UBE2A ubiquitin-conjugating enzyme E2A
UBE2C ubiquitin-conjugating enzyme E2C
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative)
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
ZWINT ZW10 interacting kinetochore protein