BRD-K33379087_tivantinib_HT29_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

142 genes differentially expressed following the BRD-K33379087_tivantinib_HT29_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ANPEP alanyl (membrane) aminopeptidase
AURKA aurora kinase A
AXL AXL receptor tyrosine kinase
BAG2 BCL2-associated athanogene 2
C8ORF4 chromosome 8 open reading frame 4
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHST1 carbohydrate (keratan sulfate Gal-6) sulfotransferase 1
CLEC11A C-type lectin domain family 11, member A
COL13A1 collagen, type XIII, alpha 1
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
CTSL cathepsin L
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
DLC1 DLC1 Rho GTPase activating protein
DLK1 delta-like 1 homolog (Drosophila)
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
FCMR Fc fragment of IgM receptor
FJX1 four jointed box 1 (Drosophila)
FOSL1 FOS-like antigen 1
GADD45B growth arrest and DNA-damage-inducible, beta
GAS2L1 growth arrest-specific 2 like 1
GMPR guanosine monophosphate reductase
IGFBP7 insulin-like growth factor binding protein 7
IGKV4-1 immunoglobulin kappa variable 4-1
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
KIF14 kinesin family member 14
KIF20A kinesin family member 20A
LAPTM4B lysosomal protein transmembrane 4 beta
LHFP lipoma HMGIC fusion partner
LMO4 LIM domain only 4
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2
MCUR1 mitochondrial calcium uniporter regulator 1
MEG3 maternally expressed 3 (non-protein coding)
MOXD1 monooxygenase, DBH-like 1
MSLN mesothelin
MT1E metallothionein 1E
NELL2 NEL-like 2 (chicken)
NTS neurotensin
OBSL1 obscurin-like 1
PACSIN3 protein kinase C and casein kinase substrate in neurons 3
PCSK1 proprotein convertase subtilisin/kexin type 1
PTPRC protein tyrosine phosphatase, receptor type, C
RAB31 RAB31, member RAS oncogene family
RABEP2 rabaptin, RAB GTPase binding effector protein 2
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SH2B3 SH2B adaptor protein 3
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLCO1B3 solute carrier organic anion transporter family, member 1B3
SPON1 spondin 1, extracellular matrix protein
STEAP3 STEAP family member 3, metalloreductase
TBC1D8 TBC1 domain family, member 8 (with GRAM domain)
THBS1 thrombospondin 1
TIMP1 TIMP metallopeptidase inhibitor 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
TRIB2 tribbles pseudokinase 2
TXNL4B thioredoxin-like 4B

decreased expression

Symbol Name
ADGRE5 adhesion G protein-coupled receptor E5
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C3 aldo-keto reductase family 1, member C3
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
AUTS2 autism susceptibility candidate 2
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5
CALB1 calbindin 1, 28kDa
CCNG2 cyclin G2
CD24 CD24 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDK1 cyclin-dependent kinase 1
CFLAR CASP8 and FADD-like apoptosis regulator
COL1A1 collagen, type I, alpha 1
CPD carboxypeptidase D
CPNE3 copine III
CREB1 cAMP responsive element binding protein 1
CYBA cytochrome b-245, alpha polypeptide
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase)
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUSP6 dual specificity phosphatase 6
EIF1AX eukaryotic translation initiation factor 1A, X-linked
FABP4 fatty acid binding protein 4, adipocyte
FBP1 fructose-1,6-bisphosphatase 1
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GINS1 GINS complex subunit 1 (Psf1 homolog)
GLS glutaminase
GPRC5A G protein-coupled receptor, class C, group 5, member A
GPX3 glutathione peroxidase 3
GSPT2 G1 to S phase transition 2
H1F0 H1 histone family, member 0
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IFITM1 interferon induced transmembrane protein 1
IGF1R insulin-like growth factor 1 receptor
KCTD12 potassium channel tetramerization domain containing 12
KIAA0101 KIAA0101
KRT14 keratin 14, type I
KRT19 keratin 19, type I
KRT6B keratin 6B, type II
LYPLA1 lysophospholipase I
MCM6 minichromosome maintenance complex component 6
MSH6 mutS homolog 6
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NSG1 neuron specific gene family member 1
NUSAP1 nucleolar and spindle associated protein 1
OSBPL1A oxysterol binding protein-like 1A
PCP4 Purkinje cell protein 4
PRKCD protein kinase C, delta
PRKCI protein kinase C, iota
PXMP2 peroxisomal membrane protein 2, 22kDa
RFC2 replication factor C (activator 1) 2, 40kDa
RGS2 regulator of G-protein signaling 2
RNF13 ring finger protein 13
RNMT RNA (guanine-7-) methyltransferase
RRM2 ribonucleotide reductase M2
SERINC3 serine incorporator 3
SMAD1 SMAD family member 1
SOX4 SRY (sex determining region Y)-box 4
SPINK1 serine peptidase inhibitor, Kazal type 1
SPINT2 serine peptidase inhibitor, Kunitz type, 2
TM9SF2 transmembrane 9 superfamily member 2
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TOMM70A translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae)
TOP2A topoisomerase (DNA) II alpha 170kDa
TOPBP1 topoisomerase (DNA) II binding protein 1
TSPAN31 tetraspanin 31
TUG1 taurine up-regulated 1 (non-protein coding)
TXNIP thioredoxin interacting protein
UBE2A ubiquitin-conjugating enzyme E2A
UBE2C ubiquitin-conjugating enzyme E2C
UGP2 UDP-glucose pyrophosphorylase 2
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZWINT ZW10 interacting kinetochore protein