BRD-K33379087_tivantinib_HA1E_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

117 genes differentially expressed following the BRD-K33379087_tivantinib_HA1E_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
BST2 bone marrow stromal cell antigen 2
CCND2 cyclin D2
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CTSL cathepsin L
CXCL8 chemokine (C-X-C motif) ligand 8
DLK1 delta-like 1 homolog (Drosophila)
DUSP22 dual specificity phosphatase 22
DUSP6 dual specificity phosphatase 6
EREG epiregulin
FOSL1 FOS-like antigen 1
G0S2 G0/G1 switch 2
H2BFS H2B histone family, member S (pseudogene)
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BF histone cluster 1, H2bf
HIST1H2BK histone cluster 1, H2bk
HMOX1 heme oxygenase 1
IFI44 interferon-induced protein 44
IFI44L interferon-induced protein 44-like
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFRD1 interferon-related developmental regulator 1
IRF7 interferon regulatory factor 7
ISG15 ISG15 ubiquitin-like modifier
ITM2A integral membrane protein 2A
MELK maternal embryonic leucine zipper kinase
MPO myeloperoxidase
MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)
MX1 MX dynamin-like GTPase 1
NLRP2 NLR family, pyrin domain containing 2
PAN2 PAN2 poly(A) specific ribonuclease subunit
PHLDA1 pleckstrin homology-like domain, family A, member 1
PIGB phosphatidylinositol glycan anchor biosynthesis, class B
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
POSTN periostin, osteoblast specific factor
PRR15L proline rich 15-like
PTX3 pentraxin 3, long
RBP1 retinol binding protein 1, cellular
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3
SPRED2 sprouty-related, EVH1 domain containing 2
TBL1X transducin (beta)-like 1X-linked
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TOB1 transducer of ERBB2, 1
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative)

decreased expression

Symbol Name
ACLY ATP citrate lyase
AK4 adenylate kinase 4
AQP1 aquaporin 1 (Colton blood group)
ASRGL1 asparaginase like 1
ATF6 activating transcription factor 6
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BACE2 beta-site APP-cleaving enzyme 2
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
C10ORF10 chromosome 10 open reading frame 10
CADM1 cell adhesion molecule 1
CALD1 caldesmon 1
CCL19 chemokine (C-C motif) ligand 19
CCNF cyclin F
COL3A1 collagen, type III, alpha 1
CPE carboxypeptidase E
CPM carboxypeptidase M
CYB5A cytochrome b5 type A (microsomal)
DCN decorin
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase)
DPT dermatopontin
DPYSL3 dihydropyrimidinase-like 3
DST dystonin
EDN1 endothelin 1
ENO1 enolase 1, (alpha)
ENO2 enolase 2 (gamma, neuronal)
EPHA3 EPH receptor A3
F13A1 coagulation factor XIII, A1 polypeptide
FHL1 four and a half LIM domains 1
FILIP1L filamin A interacting protein 1-like
FOXF1 forkhead box F1
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
IGFBP3 insulin-like growth factor binding protein 3
INSIG1 insulin induced gene 1
IPO13 importin 13
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
L1CAM L1 cell adhesion molecule
LDOC1 leucine zipper, down-regulated in cancer 1
LUM lumican
MGP matrix Gla protein
MME membrane metallo-endopeptidase
MPZL2 myelin protein zero-like 2
NDRG1 N-myc downstream regulated 1
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NPY neuropeptide Y
NREP neuronal regeneration related protein
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PDZK1IP1 PDZK1 interacting protein 1
PGK1 phosphoglycerate kinase 1
PGM1 phosphoglucomutase 1
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PLTP phospholipid transfer protein
PPIC peptidylprolyl isomerase C (cyclophilin C)
PTGIS prostaglandin I2 (prostacyclin) synthase
RCAN1 regulator of calcineurin 1
RGS5 regulator of G-protein signaling 5
RYBP RING1 and YY1 binding protein
S100A7 S100 calcium binding protein A7
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SHMT1 serine hydroxymethyltransferase 1 (soluble)
SLIT2 slit homolog 2 (Drosophila)
SPAG4 sperm associated antigen 4
SPINK1 serine peptidase inhibitor, Kazal type 1
STMN2 stathmin 2
SULF1 sulfatase 1
TMEM45A transmembrane protein 45A
TRIM2 tripartite motif containing 2
VDAC1 voltage-dependent anion channel 1
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon