BRD-K33379087_tivantinib_A375_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

174 genes differentially expressed following the BRD-K33379087_tivantinib_A375_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACTG2 actin, gamma 2, smooth muscle, enteric
ACTN1 actinin, alpha 1
ADM adrenomedullin
ADRB2 adrenoceptor beta 2, surface
AKAP8L A kinase (PRKA) anchor protein 8-like
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase
APOD apolipoprotein D
ATF3 activating transcription factor 3
AVPI1 arginine vasopressin-induced 1
BAX BCL2-associated X protein
BTG2 BTG family, member 2
CCNA1 cyclin A1
CCND2 cyclin D2
CD163 CD163 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CFD complement factor D (adipsin)
CLEC11A C-type lectin domain family 11, member A
CUX2 cut-like homeobox 2
CXCL13 chemokine (C-X-C motif) ligand 13
CYR61 cysteine-rich, angiogenic inducer, 61
DDB2 damage-specific DNA binding protein 2, 48kDa
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EGR1 early growth response 1
EGR3 early growth response 3
EMP3 epithelial membrane protein 3
FAM46A family with sequence similarity 46, member A
FAS Fas cell surface death receptor
FCMR Fc fragment of IgM receptor
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GADD45A growth arrest and DNA-damage-inducible, alpha
GDF15 growth differentiation factor 15
GLUL glutamate-ammonia ligase
GPRC5A G protein-coupled receptor, class C, group 5, member A
H2BFS H2B histone family, member S (pseudogene)
HBEGF heparin-binding EGF-like growth factor
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BE histone cluster 1, H2be
HIST1H2BF histone cluster 1, H2bf
HIST1H2BG histone cluster 1, H2bg
HIST1H2BH histone cluster 1, H2bh
HIST1H2BK histone cluster 1, H2bk
HIST1H3H histone cluster 1, H3h
HIST1H4H histone cluster 1, H4h
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HSPA4L heat shock 70kDa protein 4-like
HSPB8 heat shock 22kDa protein 8
IER3 immediate early response 3
IER5 immediate early response 5
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
JCHAIN joining chain of multimeric IgA and IgM
JUNB jun B proto-oncogene
KCTD5 potassium channel tetramerization domain containing 5
KLHL21 kelch-like family member 21
KRT14 keratin 14, type I
KRT17 keratin 17, type I
LMO3 LIM domain only 3 (rhombotin-like 2)
LTF lactotransferrin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAGEB2 melanoma antigen family B2
MMP9 matrix metallopeptidase 9
MUC5B mucin 5B, oligomeric mucus/gel-forming
MYO5C myosin VC
NNMT nicotinamide N-methyltransferase
NOTCH1 notch 1
NPR3 natriuretic peptide receptor 3
NR4A3 nuclear receptor subfamily 4, group A, member 3
NUPR1 nuclear protein, transcriptional regulator, 1
OXSR1 oxidative stress responsive 1
PER2 period circadian clock 2
PLCB4 phospholipase C, beta 4
PLK2 polo-like kinase 2
POLR1D polymerase (RNA) I polypeptide D, 16kDa
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRKCB protein kinase C, beta
PRSS21 protease, serine, 21 (testisin)
PSTPIP2 proline-serine-threonine phosphatase interacting protein 2
PTP4A1 protein tyrosine phosphatase type IVA, member 1
RGS1 regulator of G-protein signaling 1
RGS10 regulator of G-protein signaling 10
RIOK3 RIO kinase 3
RPS27L ribosomal protein S27-like
S100A8 S100 calcium binding protein A8
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SESN1 sestrin 1
SFN stratifin
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SSX1 synovial sarcoma, X breakpoint 1
STAR steroidogenic acute regulatory protein
STXBP2 syntaxin binding protein 2
TAGLN transgelin
TCF4 transcription factor 4
TIGAR TP53 induced glycolysis regulatory phosphatase
TIMP1 TIMP metallopeptidase inhibitor 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TUFT1 tuftelin 1
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ADGRG6 adhesion G protein-coupled receptor G6
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ATXN1 ataxin 1
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5
BIN1 bridging integrator 1
BSCL2 Berardinelli-Seip congenital lipodystrophy 2 (seipin)
CADM1 cell adhesion molecule 1
CCNF cyclin F
CDK1 cyclin-dependent kinase 1
CFI complement factor I
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
COL6A1 collagen, type VI, alpha 1
CRYL1 crystallin, lambda 1
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL5 chemokine (C-X-C motif) ligand 5
CXCL6 chemokine (C-X-C motif) ligand 6
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DPYSL3 dihydropyrimidinase-like 3
ERBB3 erb-b2 receptor tyrosine kinase 3
GNG11 guanine nucleotide binding protein (G protein), gamma 11
HMGA2 high mobility group AT-hook 2
HOPX HOP homeobox
HOXA5 homeobox A5
KIF11 kinesin family member 11
KIF18B kinesin family member 18B
KRT13 keratin 13, type I
LAPTM4B lysosomal protein transmembrane 4 beta
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
MELK maternal embryonic leucine zipper kinase
MET MET proto-oncogene, receptor tyrosine kinase
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MMD monocyte to macrophage differentiation-associated
NES nestin
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NID1 nidogen 1
NREP neuronal regeneration related protein
NUSAP1 nucleolar and spindle associated protein 1
PBK PDZ binding kinase
PGM1 phosphoglucomutase 1
PLAT plasminogen activator, tissue
PLP1 proteolipid protein 1
PSD3 pleckstrin and Sec7 domain containing 3
REG3A regenerating islet-derived 3 alpha
RGS5 regulator of G-protein signaling 5
RRM2 ribonucleotide reductase M2
S100A7 S100 calcium binding protein A7
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SHCBP1 SHC SH2-domain binding protein 1
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
SMAD1 SMAD family member 1
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SRPX sushi-repeat containing protein, X-linked
SRPX2 sushi-repeat containing protein, X-linked 2
TFPI2 tissue factor pathway inhibitor 2
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TOP2A topoisomerase (DNA) II alpha 170kDa
TUBB tubulin, beta class I
TUBB2A tubulin, beta 2A class IIa
TUBB2B tubulin, beta 2B class IIb
TUBB3 tubulin, beta 3 class III
TUBB4B tubulin, beta 4B class IVb
TUSC3 tumor suppressor candidate 3
UBE2A ubiquitin-conjugating enzyme E2A
UBE2C ubiquitin-conjugating enzyme E2C
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VCAM1 vascular cell adhesion molecule 1
VCAN versican
WWTR1 WW domain containing transcription regulator 1