BRD-K33308633_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

76 genes differentially expressed following the BRD-K33308633_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
AKR1C3 aldo-keto reductase family 1, member C3
CD1A CD1a molecule
CD58 CD58 molecule
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CXCL14 chemokine (C-X-C motif) ligand 14
CYTIP cytohesin 1 interacting protein
DDIT4 DNA-damage-inducible transcript 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP1 dual specificity phosphatase 1
DUSP2 dual specificity phosphatase 2
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
EGLN3 egl-9 family hypoxia-inducible factor 3
EGR1 early growth response 1
EGR2 early growth response 2
FAM69A family with sequence similarity 69, member A
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
FTH1 ferritin, heavy polypeptide 1
FZD7 frizzled class receptor 7
GADD45A growth arrest and DNA-damage-inducible, alpha
GCLM glutamate-cysteine ligase, modifier subunit
GFOD1 glucose-fructose oxidoreductase domain containing 1
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
HMOX1 heme oxygenase 1
HOPX HOP homeobox
HSPA1A heat shock 70kDa protein 1A
HSPA2 heat shock 70kDa protein 2
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IER2 immediate early response 2
IER5 immediate early response 5
IGL immunoglobulin lambda locus
JUN jun proto-oncogene
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
KRT6B keratin 6B, type II
LIMCH1 LIM and calponin homology domains 1
LTF lactotransferrin
MAP7 microtubule-associated protein 7
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
NQO1 NAD(P)H dehydrogenase, quinone 1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
PERP PERP, TP53 apoptosis effector
PIR pirin (iron-binding nuclear protein)
PLIN2 perilipin 2
PTHLH parathyroid hormone-like hormone
RND3 Rho family GTPase 3
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SGK1 serum/glucocorticoid regulated kinase 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SOX9 SRY (sex determining region Y)-box 9
TMEM158 transmembrane protein 158 (gene/pseudogene)
TRIB1 tribbles pseudokinase 1
UGDH UDP-glucose 6-dehydrogenase
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
CCND2 cyclin D2
CDC42 cell division cycle 42
GPD1L glycerol-3-phosphate dehydrogenase 1-like
IGFBP5 insulin-like growth factor binding protein 5
MX1 MX dynamin-like GTPase 1
NFIB nuclear factor I/B
RAB11FIP1 RAB11 family interacting protein 1 (class I)
SDC2 syndecan 2
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
TMEM5 transmembrane protein 5
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNS1 tensin 1
TSPAN13 tetraspanin 13
TUSC3 tumor suppressor candidate 3
TXNIP thioredoxin interacting protein
UFM1 ubiquitin-fold modifier 1
VCAN versican