BRD-K33116223_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

82 genes differentially expressed following the BRD-K33116223_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADGRG6 adhesion G protein-coupled receptor G6
ARG2 arginase 2
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2
BLNK B-cell linker
CA2 carbonic anhydrase II
CAPG capping protein (actin filament), gelsolin-like
CCR2 chemokine (C-C motif) receptor 2
CD40 CD40 molecule, TNF receptor superfamily member 5
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYTIP cytohesin 1 interacting protein
ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1
EPB41L3 erythrocyte membrane protein band 4.1-like 3
FGFR2 fibroblast growth factor receptor 2
FTH1 ferritin, heavy polypeptide 1
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
GPR137B G protein-coupled receptor 137B
GREM1 gremlin 1, DAN family BMP antagonist
HBB hemoglobin, beta
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HHEX hematopoietically expressed homeobox
HIST1H1C histone cluster 1, H1c
HSPA1A heat shock 70kDa protein 1A
HYOU1 hypoxia up-regulated 1
ISG20 interferon stimulated exonuclease gene 20kDa
KIAA1598
KRT18 keratin 18, type I
LITAF lipopolysaccharide-induced TNF factor
LOC100505650 uncharacterized LOC100505650
LYZ lysozyme
MAP7 microtubule-associated protein 7
MEST mesoderm specific transcript
MSMB microseminoprotein, beta-
NEFH neurofilament, heavy polypeptide
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PCNA proliferating cell nuclear antigen
PMM2 phosphomannomutase 2
PRNP prion protein
QPCT glutaminyl-peptide cyclotransferase
RGCC regulator of cell cycle
RHOBTB3 Rho-related BTB domain containing 3
RRBP1 ribosome binding protein 1
RTN1 reticulon 1
S100A1 S100 calcium binding protein A1
SEC23B Sec23 homolog B (S. cerevisiae)
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SLC17A3 solute carrier family 17 (organic anion transporter), member 3
SRGN serglycin
SST somatostatin
ST18 suppression of tumorigenicity 18, zinc finger
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TMSB15A thymosin beta 15a
TPD52L1 tumor protein D52-like 1
UBE2J1 ubiquitin-conjugating enzyme E2, J1

decreased expression

Symbol Name
BZW2 basic leucine zipper and W2 domains 2
CD59 CD59 molecule, complement regulatory protein
EFNB2 ephrin-B2
EGR3 early growth response 3
FAM46A family with sequence similarity 46, member A
FOLR1 folate receptor 1 (adult)
GLS glutaminase
GOLGA8A golgin A8 family, member A
GPM6B glycoprotein M6B
IGF1R insulin-like growth factor 1 receptor
IL13RA2 interleukin 13 receptor, alpha 2
KLF10 Kruppel-like factor 10
KLF5 Kruppel-like factor 5 (intestinal)
LOX lysyl oxidase
MARCKS myristoylated alanine-rich protein kinase C substrate
NOTCH3 notch 3
PFN2 profilin 2
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PTN pleiotrophin
PTX3 pentraxin 3, long
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SRPX sushi-repeat containing protein, X-linked
TIMP3 TIMP metallopeptidase inhibitor 3
TWIST1 twist family bHLH transcription factor 1
TYRP1 tyrosinase-related protein 1
UBE2E3 ubiquitin-conjugating enzyme E2E 3
UGCG UDP-glucose ceramide glucosyltransferase