BRD-K33086940_JAS07_007_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

136 genes differentially expressed following the BRD-K33086940_JAS07_007_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACTN1 actinin, alpha 1
ADM adrenomedullin
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
AREG amphiregulin
ARHGAP29 Rho GTPase activating protein 29
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATP13A3 ATPase type 13A3
BMP2 bone morphogenetic protein 2
C8ORF4 chromosome 8 open reading frame 4
CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CEP57 centrosomal protein 57kDa
CES1 carboxylesterase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CRABP1 cellular retinoic acid binding protein 1
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT4 DNA-damage-inducible transcript 4
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
F2RL1 coagulation factor II (thrombin) receptor-like 1
F3 coagulation factor III (thromboplastin, tissue factor)
FAM107A family with sequence similarity 107, member A
FNDC3B fibronectin type III domain containing 3B
FOSL1 FOS-like antigen 1
G0S2 G0/G1 switch 2
GRIA2 glutamate receptor, ionotropic, AMPA 2
HES1 hes family bHLH transcription factor 1
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1
ICAM1 intercellular adhesion molecule 1
IER3 immediate early response 3
IL32 interleukin 32
INSM1 insulinoma-associated 1
ITGA6 integrin, alpha 6
KDM5A lysine (K)-specific demethylase 5A
KIF5C kinesin family member 5C
KLHL9 kelch-like family member 9
LAMB3 laminin, beta 3
LDLR low density lipoprotein receptor
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5
MECOM MDS1 and EVI1 complex locus
MGLL monoglyceride lipase
MT1E metallothionein 1E
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1X metallothionein 1X
OXA1L oxidase (cytochrome c) assembly 1-like
PARL presenilin associated, rhomboid-like
PHLDA2 pleckstrin homology-like domain, family A, member 2
PKP2 plakophilin 2
PLAU plasminogen activator, urokinase
PLAUR plasminogen activator, urokinase receptor
PPARG peroxisome proliferator-activated receptor gamma
PROM1 prominin 1
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
PSMF1 proteasome (prosome, macropain) inhibitor subunit 1 (PI31)
RDX radixin
RNF167 ring finger protein 167
RRAGD Ras-related GTP binding D
S100A2 S100 calcium binding protein A2
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SAT1 spermidine/spermine N1-acetyltransferase 1
SCG5 secretogranin V
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SQSTM1 sequestosome 1
STX1A syntaxin 1A (brain)
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TM4SF1 transmembrane 4 L six family member 1
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TPD52 tumor protein D52
TSC22D1 TSC22 domain family, member 1
TSKU tsukushi, small leucine rich proteoglycan
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VEGFA vascular endothelial growth factor A
VTCN1 V-set domain containing T cell activation inhibitor 1
WIF1 WNT inhibitory factor 1

decreased expression

Symbol Name
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5
ACPP acid phosphatase, prostate
ADRB2 adrenoceptor beta 2, surface
AKAP1 A kinase (PRKA) anchor protein 1
ALDH4A1 aldehyde dehydrogenase 4 family, member A1
ANKRD36B ankyrin repeat domain 36B
ANXA1 annexin A1
ANXA2 annexin A2
BANK1 B-cell scaffold protein with ankyrin repeats 1
BCHE butyrylcholinesterase
BPTF bromodomain PHD finger transcription factor
C6ORF62 chromosome 6 open reading frame 62
C7 complement component 7
CAST calpastatin
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta
CFD complement factor D (adipsin)
CPA3 carboxypeptidase A3 (mast cell)
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CXCL12 chemokine (C-X-C motif) ligand 12
DPYSL2 dihydropyrimidinase-like 2
DPYSL3 dihydropyrimidinase-like 3
EPHA3 EPH receptor A3
FHL1 four and a half LIM domains 1
GJA1 gap junction protein, alpha 1, 43kDa
HOXC6 homeobox C6
HSPA8 heat shock 70kDa protein 8
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15
KIAA0753 KIAA0753
LUC7L3 LUC7-like 3 (S. cerevisiae)
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MSMB microseminoprotein, beta-
NBPF10 neuroblastoma breakpoint family, member 10
NELL2 NEL-like 2 (chicken)
NR2F2 nuclear receptor subfamily 2, group F, member 2
PIEZO2 piezo-type mechanosensitive ion channel component 2
PRKCA protein kinase C, alpha
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTPRC protein tyrosine phosphatase, receptor type, C
RTN2 reticulon 2
S100A10 S100 calcium binding protein A10
SCUBE2 signal peptide, CUB domain, EGF-like 2
SERINC5 serine incorporator 5
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SULF1 sulfatase 1
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TOP2A topoisomerase (DNA) II alpha 170kDa
TPBG trophoblast glycoprotein
TRIM22 tripartite motif containing 22
VCAN versican
ZNF586 zinc finger protein 586