BRD-K33045404_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

94 genes differentially expressed following the BRD-K33045404_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALOX5 arachidonate 5-lipoxygenase
ARG2 arginase 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
C10ORF10 chromosome 10 open reading frame 10
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
COL11A1 collagen, type XI, alpha 1
CPE carboxypeptidase E
DCN decorin
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DPP4 dipeptidyl-peptidase 4
DUSP1 dual specificity phosphatase 1
EIF5A eukaryotic translation initiation factor 5A
EML3 echinoderm microtubule associated protein like 3
FADS1 fatty acid desaturase 1
FAM69A family with sequence similarity 69, member A
FLT1 fms-related tyrosine kinase 1
GJA1 gap junction protein, alpha 1, 43kDa
GLS glutaminase
GRB7 growth factor receptor-bound protein 7
H1F0 H1 histone family, member 0
HAPLN1 hyaluronan and proteoglycan link protein 1
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
IER3 immediate early response 3
KCNK3 potassium channel, two pore domain subfamily K, member 3
LMO3 LIM domain only 3 (rhombotin-like 2)
LTB lymphotoxin beta (TNF superfamily, member 3)
LXN latexin
MAN1A1 mannosidase, alpha, class 1A, member 1
MARS methionyl-tRNA synthetase
MKNK1 MAP kinase interacting serine/threonine kinase 1
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MME membrane metallo-endopeptidase
NELL2 NEL-like 2 (chicken)
NMU neuromedin U
NPTX2 neuronal pentraxin II
PDZK1IP1 PDZK1 interacting protein 1
PTGIS prostaglandin I2 (prostacyclin) synthase
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SLC25A14 solute carrier family 25 (mitochondrial carrier, brain), member 14
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SOD2 superoxide dismutase 2, mitochondrial
TFPI2 tissue factor pathway inhibitor 2
TPSAB1 tryptase alpha/beta 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VTCN1 V-set domain containing T cell activation inhibitor 1

decreased expression

Symbol Name
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ABHD2 abhydrolase domain containing 2
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide
AGR2 anterior gradient 2
AK4 adenylate kinase 4
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
CES1 carboxylesterase 1
CLU clusterin
CPD carboxypeptidase D
CSRP1 cysteine and glycine-rich protein 1
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DHRS2 dehydrogenase/reductase (SDR family) member 2
DKK1 dickkopf WNT signaling pathway inhibitor 1
DUSP3 dual specificity phosphatase 3
FABP1 fatty acid binding protein 1, liver
GADD45B growth arrest and DNA-damage-inducible, beta
GOLM1 golgi membrane protein 1
IGFBP7 insulin-like growth factor binding protein 7
KLF4 Kruppel-like factor 4 (gut)
KYNU kynureninase
LAMP5 lysosomal-associated membrane protein family, member 5
LGALS3 lectin, galactoside-binding, soluble, 3
LMO2 LIM domain only 2 (rhombotin-like 1)
MEIS1 Meis homeobox 1
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
NIP7 NIP7, nucleolar pre-rRNA processing protein
NUP98 nucleoporin 98kDa
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PDLIM1 PDZ and LIM domain 1
PLAC8 placenta-specific 8
PLEC plectin
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
PTCH1 patched 1
PTGER4 prostaglandin E receptor 4 (subtype EP4)
RPS4Y1 ribosomal protein S4, Y-linked 1
RRP8 ribosomal RNA processing 8, methyltransferase, homolog (yeast)
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SFN stratifin
SPARCL1 SPARC-like 1 (hevin)
TBX2 T-box 2
TFF3 trefoil factor 3 (intestinal)
TPM4 tropomyosin 4
TSPAN8 tetraspanin 8
TXN thioredoxin