BRD-K32944375_NCGC00184834-01_A375_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

234 genes differentially expressed following the BRD-K32944375_NCGC00184834-01_A375_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACTG2 actin, gamma 2, smooth muscle, enteric
ADGRE5 adhesion G protein-coupled receptor E5
AGRN agrin
AMIGO2 adhesion molecule with Ig-like domain 2
ANKRD10 ankyrin repeat domain 10
AREG amphiregulin
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
BLCAP bladder cancer associated protein
BLNK B-cell linker
BRD2 bromodomain containing 2
BTG2 BTG family, member 2
CARKD carbohydrate kinase domain containing
CCND2 cyclin D2
CD44 CD44 molecule (Indian blood group)
CD9 CD9 molecule
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CES1 carboxylesterase 1
CLDN8 claudin 8
COL4A5 collagen, type IV, alpha 5
CTSA cathepsin A
CTSZ cathepsin Z
CYFIP2 cytoplasmic FMR1 interacting protein 2
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DDB2 damage-specific DNA binding protein 2, 48kDa
DEGS1 delta(4)-desaturase, sphingolipid 1
DST dystonin
DUSP1 dual specificity phosphatase 1
F13A1 coagulation factor XIII, A1 polypeptide
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GAS6 growth arrest-specific 6
GATA3 GATA binding protein 3
GATA6 GATA binding protein 6
GSE1 Gse1 coiled-coil protein
GSN gelsolin
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BG histone cluster 1, H2bg
HIST1H2BK histone cluster 1, H2bk
HIST2H2BE histone cluster 2, H2be
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
IER5 immediate early response 5
IGFBP5 insulin-like growth factor binding protein 5
INHBA inhibin, beta A
IRF6 interferon regulatory factor 6
ISG15 ISG15 ubiquitin-like modifier
JAG1 jagged 1
KDM5B lysine (K)-specific demethylase 5B
KLF4 Kruppel-like factor 4 (gut)
KRT20 keratin 20, type I
KRT8 keratin 8, type II
LMNA lamin A/C
LMO3 LIM domain only 3 (rhombotin-like 2)
LOC100272216 uncharacterized LOC100272216
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAN1A1 mannosidase, alpha, class 1A, member 1
MAOA monoamine oxidase A
MAPK13 mitogen-activated protein kinase 13
MUC2 mucin 2, oligomeric mucus/gel-forming
MVP major vault protein
MYH11 myosin, heavy chain 11, smooth muscle
MYO6 myosin VI
NACC2 NACC family member 2, BEN and BTB (POZ) domain containing
NBPF10 neuroblastoma breakpoint family, member 10
NCF2 neutrophil cytosolic factor 2
NDRG1 N-myc downstream regulated 1
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NT5E 5'-nucleotidase, ecto (CD73)
OSR2 odd-skipped related transciption factor 2
PEG3 paternally expressed 3
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLA2G15 phospholipase A2, group XV
PLAU plasminogen activator, urokinase
PLN phospholamban
PLXNA1 plexin A1
PNP purine nucleoside phosphorylase
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTPRO protein tyrosine phosphatase, receptor type, O
RGS2 regulator of G-protein signaling 2
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SNAI2 snail family zinc finger 2
STON1 stonin 1
TBX3 T-box 3
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TIGAR TP53 induced glycolysis regulatory phosphatase
TMEM158 transmembrane protein 158 (gene/pseudogene)
TOB1 transducer of ERBB2, 1
TPP1 tripeptidyl peptidase I
TUFT1 tuftelin 1
TXNIP thioredoxin interacting protein
UBQLN2 ubiquilin 2
YPEL5 yippee-like 5 (Drosophila)
ZMAT3 zinc finger, matrin-type 3

decreased expression

Symbol Name
ADD3 adducin 3 (gamma)
AKR1C3 aldo-keto reductase family 1, member C3
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
ANXA7 annexin A7
ASH2L ash2 (absent, small, or homeotic)-like (Drosophila)
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATP9A ATPase, class II, type 9A
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BAALC brain and acute leukemia, cytoplasmic
BACE2 beta-site APP-cleaving enzyme 2
BIRC5 baculoviral IAP repeat containing 5
C3 complement component 3
CALU calumenin
CAPNS1 calpain, small subunit 1
CBFB core-binding factor, beta subunit
CCNA2 cyclin A2
CCNE2 cyclin E2
CCNF cyclin F
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CDC42 cell division cycle 42
CDK1 cyclin-dependent kinase 1
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CENPA centromere protein A
CEP55 centrosomal protein 55kDa
CHPT1 choline phosphotransferase 1
CNN3 calponin 3, acidic
CNOT7 CCR4-NOT transcription complex, subunit 7
CP ceruloplasmin (ferroxidase)
CRTAP cartilage associated protein
CYB5A cytochrome b5 type A (microsomal)
CYTL1 cytokine-like 1
DCK deoxycytidine kinase
DEPDC1 DEP domain containing 1
DHFR dihydrofolate reductase
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3
DUT deoxyuridine triphosphatase
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
ERBB3 erb-b2 receptor tyrosine kinase 3
FABP7 fatty acid binding protein 7, brain
FAM134B family with sequence similarity 134, member B
FAM35A family with sequence similarity 35, member A
FOLR1 folate receptor 1 (adult)
FOSL1 FOS-like antigen 1
FSTL1 follistatin-like 1
GPC3 glypican 3
GPX1 glutathione peroxidase 1
GSAP gamma-secretase activating protein
GTF3A general transcription factor IIIA
GTSE1 G-2 and S-phase expressed 1
HLA-DRA major histocompatibility complex, class II, DR alpha
HMG20B high mobility group 20B
HMMR hyaluronan-mediated motility receptor (RHAMM)
HPRT1 hypoxanthine phosphoribosyltransferase 1
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
HSPA8 heat shock 70kDa protein 8
IFRD2 interferon-related developmental regulator 2
IGFBP3 insulin-like growth factor binding protein 3
IGFBP7 insulin-like growth factor binding protein 7
IL6ST interleukin 6 signal transducer
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
ITGA6 integrin, alpha 6
ITGB1BP1 integrin beta 1 binding protein 1
KIF15 kinesin family member 15
KIF20A kinesin family member 20A
KIF23 kinesin family member 23
KIF2C kinesin family member 2C
KRT6B keratin 6B, type II
LAMC1 laminin, gamma 1 (formerly LAMB2)
LAPTM4B lysosomal protein transmembrane 4 beta
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LYPLA1 lysophospholipase I
LYRM4 LYR motif containing 4
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MCM10 minichromosome maintenance complex component 10
MCM4 minichromosome maintenance complex component 4
MIA melanoma inhibitory activity
MOK MOK protein kinase
MTERF3 mitochondrial transcription termination factor 3
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
NAP1L1 nucleosome assembly protein 1-like 1
NBL1 neuroblastoma 1, DAN family BMP antagonist
NBN nibrin
NNMT nicotinamide N-methyltransferase
NPM3 nucleophosmin/nucleoplasmin 3
NRN1 neuritin 1
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PARP1 poly (ADP-ribose) polymerase 1
PBK PDZ binding kinase
PFAS phosphoribosylformylglycinamidine synthase
PHGDH phosphoglycerate dehydrogenase
PITX1 paired-like homeodomain 1
PLK1 polo-like kinase 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLR3K polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PRMT1 protein arginine methyltransferase 1
PSAT1 phosphoserine aminotransferase 1
PSPH phosphoserine phosphatase
PXMP2 peroxisomal membrane protein 2, 22kDa
PYCR1 pyrroline-5-carboxylate reductase 1
RAD54B RAD54 homolog B (S. cerevisiae)
RCC1 regulator of chromosome condensation 1
RFC2 replication factor C (activator 1) 2, 40kDa
RFC3 replication factor C (activator 1) 3, 38kDa
RGS1 regulator of G-protein signaling 1
RNASEH2A ribonuclease H2, subunit A
RPA3 replication protein A3, 14kDa
RPL22 ribosomal protein L22
S100B S100 calcium binding protein B
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLPI secretory leukocyte peptidase inhibitor
SNX10 sorting nexin 10
SPARCL1 SPARC-like 1 (hevin)
SPC25 SPC25, NDC80 kinetochore complex component
SRM spermidine synthase
SRP72 signal recognition particle 72kDa
STC2 stanniocalcin 2
STK32B serine/threonine kinase 32B
STMN1 stathmin 1
TGFBI transforming growth factor, beta-induced, 68kDa
TIMP3 TIMP metallopeptidase inhibitor 3
TM4SF1 transmembrane 4 L six family member 1
TMEM165 transmembrane protein 165
TMPO thymopoietin
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TPM1 tropomyosin 1 (alpha)
TPX2 TPX2, microtubule-associated
TSPAN13 tetraspanin 13
TUBB tubulin, beta class I
UGCG UDP-glucose ceramide glucosyltransferase