BRD-K32896438_-666_ASC_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

126 genes differentially expressed following the BRD-K32896438_-666_ASC_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AQP3 aquaporin 3 (Gill blood group)
ATF3 activating transcription factor 3
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
BAG3 BCL2-associated athanogene 3
CACYBP calcyclin binding protein
CCL2 chemokine (C-C motif) ligand 2
CCL20 chemokine (C-C motif) ligand 20
CD44 CD44 molecule (Indian blood group)
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CLDN10 claudin 10
CTSH cathepsin H
CTSL cathepsin L
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DOCK9 dedicator of cytokinesis 9
DUSP5 dual specificity phosphatase 5
FAM57A family with sequence similarity 57, member A
FHL2 four and a half LIM domains 2
FOSL1 FOS-like antigen 1
GABPB1 GA binding protein transcription factor, beta subunit 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GCH1 GTP cyclohydrolase 1
GDF15 growth differentiation factor 15
HBEGF heparin-binding EGF-like growth factor
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HSPA1A heat shock 70kDa protein 1A
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPH1 heat shock 105kDa/110kDa protein 1
IER3 immediate early response 3
IER5 immediate early response 5
IL6 interleukin 6
INHBA inhibin, beta A
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KLF4 Kruppel-like factor 4 (gut)
LGALS8 lectin, galactoside-binding, soluble, 8
LIF leukemia inhibitory factor
LRRC59 leucine rich repeat containing 59
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAST4 microtubule associated serine/threonine kinase family member 4
MCL1 myeloid cell leukemia 1
NUCB2 nucleobindin 2
NUPL1 nucleoporin like 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAUR plasminogen activator, urokinase receptor
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PNP purine nucleoside phosphorylase
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RALA v-ral simian leukemia viral oncogene homolog A (ras related)
RGS2 regulator of G-protein signaling 2
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLIT2 slit homolog 2 (Drosophila)
SOD2 superoxide dismutase 2, mitochondrial
SPINK1 serine peptidase inhibitor, Kazal type 1
SPINT2 serine peptidase inhibitor, Kunitz type, 2
SQSTM1 sequestosome 1
SRSF7 serine/arginine-rich splicing factor 7
TBX2 T-box 2
TNC tenascin C
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TP53BP2 tumor protein p53 binding protein 2
UPP1 uridine phosphorylase 1

decreased expression

Symbol Name
ACACB acetyl-CoA carboxylase beta
ACAT1 acetyl-CoA acetyltransferase 1
ADIPOQ adiponectin, C1Q and collagen domain containing
ALDOC aldolase C, fructose-bisphosphate
APMAP adipocyte plasma membrane associated protein
BDH1 3-hydroxybutyrate dehydrogenase, type 1
BST2 bone marrow stromal cell antigen 2
CD24 CD24 molecule
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CKB creatine kinase, brain
CPVL carboxypeptidase, vitellogenic-like
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DHCR7 7-dehydrocholesterol reductase
DUSP4 dual specificity phosphatase 4
ECI1 enoyl-CoA delta isomerase 1
EPB41L4B erythrocyte membrane protein band 4.1 like 4B
FADS2 fatty acid desaturase 2
FAM162A family with sequence similarity 162, member A
G0S2 G0/G1 switch 2
GPD1 glycerol-3-phosphate dehydrogenase 1 (soluble)
GSE1 Gse1 coiled-coil protein
GYG2 glycogenin 2
HADH hydroxyacyl-CoA dehydrogenase
HMGN3 high mobility group nucleosomal binding domain 3
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
HSDL2 hydroxysteroid dehydrogenase like 2
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)
MARC1 mitochondrial amidoxime reducing component 1
NMU neuromedin U
NPY1R neuropeptide Y receptor Y1
NRN1 neuritin 1
PDZK1 PDZ domain containing 1
PECR peroxisomal trans-2-enoyl-CoA reductase
PLIN1 perilipin 1
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
PPP1R1A protein phosphatase 1, regulatory (inhibitor) subunit 1A
PPP1R3C protein phosphatase 1, regulatory subunit 3C
RBM47 RNA binding motif protein 47
RBP4 retinol binding protein 4, plasma
S100A12 S100 calcium binding protein A12
SC5D sterol-C5-desaturase
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TIMP4 TIMP metallopeptidase inhibitor 4
TM7SF2 transmembrane 7 superfamily member 2
ZNF185 zinc finger protein 185 (LIM domain)