BRD-K32610195_BL-095_VCAP_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

215 genes differentially expressed following the BRD-K32610195_BL-095_VCAP_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ACLY ATP citrate lyase
ACSL3 acyl-CoA synthetase long-chain family member 3
ADIPOR2 adiponectin receptor 2
ANKRD10 ankyrin repeat domain 10
ANXA5 annexin A5
ARCN1 archain 1
ARF4 ADP-ribosylation factor 4
ARFIP2 ADP-ribosylation factor interacting protein 2
ARMCX3 armadillo repeat containing, X-linked 3
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
BASP1 brain abundant, membrane attached signal protein 1
BIK BCL2-interacting killer (apoptosis-inducing)
C6ORF62 chromosome 6 open reading frame 62
CD47 CD47 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHI3L2 chitinase 3-like 2
COBL cordon-bleu WH2 repeat protein
COPB2 coatomer protein complex, subunit beta 2 (beta prime)
CREB3L1 cAMP responsive element binding protein 3-like 1
CUX2 cut-like homeobox 2
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
DDIT4 DNA-damage-inducible transcript 4
DSP desmoplakin
ELL2 elongation factor, RNA polymerase II, 2
ELOVL5 ELOVL fatty acid elongase 5
ETNK1 ethanolamine kinase 1
FADS1 fatty acid desaturase 1
FKBP1B FK506 binding protein 1B, 12.6 kDa
FN1 fibronectin 1
FOXO4 forkhead box O4
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GLRX glutaredoxin (thioltransferase)
GOLT1B golgi transport 1B
HEBP2 heme binding protein 2
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
IDI1 isopentenyl-diphosphate delta isomerase 1
INSIG1 insulin induced gene 1
IQGAP2 IQ motif containing GTPase activating protein 2
IRS2 insulin receptor substrate 2
KLK2 kallikrein-related peptidase 2
LAMC2 laminin, gamma 2
LDLR low density lipoprotein receptor
LGMN legumain
LINC00341 long intergenic non-protein coding RNA 341
LPXN leupaxin
MAGED1 melanoma antigen family D1
MAP7 microtubule-associated protein 7
MAPK6 mitogen-activated protein kinase 6
MIR22HG MIR22 host gene
MSMB microseminoprotein, beta-
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NKX3-1 NK3 homeobox 1
NPY neuropeptide Y
NUCB2 nucleobindin 2
ORMDL2 ORMDL sphingolipid biosynthesis regulator 2
PDLIM5 PDZ and LIM domain 5
PDXK pyridoxal (pyridoxine, vitamin B6) kinase
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PRKCD protein kinase C, delta
RAB1A RAB1A, member RAS oncogene family
RAB4A RAB4A, member RAS oncogene family
RAP1GAP RAP1 GTPase activating protein
RBP4 retinol binding protein 4, plasma
RCAN1 regulator of calcineurin 1
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
SAR1B secretion associated, Ras related GTPase 1B
SAT1 spermidine/spermine N1-acetyltransferase 1
SC5D sterol-C5-desaturase
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SEC14L2 SEC14-like 2 (S. cerevisiae)
SEC22B SEC22 vesicle trafficking protein homolog B (S. cerevisiae) (gene/pseudogene)
SERINC5 serine incorporator 5
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC31A2 solute carrier family 31 (copper transporter), member 2
SNAP23 synaptosomal-associated protein, 23kDa
SOX9 SRY (sex determining region Y)-box 9
SPDEF SAM pointed domain containing ETS transcription factor
SRP14 signal recognition particle 14kDa (homologous Alu RNA binding protein)
TF transferrin
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TM9SF2 transmembrane 9 superfamily member 2
TMED10 transmembrane emp24-like trafficking protein 10 (yeast)
TXNIP thioredoxin interacting protein
WIPI1 WD repeat domain, phosphoinositide interacting 1
WSB2 WD repeat and SOCS box containing 2
XBP1 X-box binding protein 1

decreased expression

Symbol Name
ADGRF5 adhesion G protein-coupled receptor F5
ASS1 argininosuccinate synthase 1
BIRC5 baculoviral IAP repeat containing 5
BOP1 block of proliferation 1
BRCA1 breast cancer 1, early onset
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C20ORF27 chromosome 20 open reading frame 27
CAV1 caveolin 1, caveolae protein, 22kDa
CCDC85B coiled-coil domain containing 85B
CCL5 chemokine (C-C motif) ligand 5
CCNA2 cyclin A2
CCNB2 cyclin B2
CCND2 cyclin D2
CCNE2 cyclin E2
CDC25A cell division cycle 25A
CDC25B cell division cycle 25B
CDK1 cyclin-dependent kinase 1
CDK4 cyclin-dependent kinase 4
CDT1 chromatin licensing and DNA replication factor 1
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CENPF centromere protein F, 350/400kDa
CENPU centromere protein U
CHEK2 checkpoint kinase 2
CHST1 carbohydrate (keratan sulfate Gal-6) sulfotransferase 1
CSE1L CSE1 chromosome segregation 1-like (yeast)
CTSC cathepsin C
CXCL14 chemokine (C-X-C motif) ligand 14
DEPTOR DEP domain containing MTOR-interacting protein
DHFR dihydrofolate reductase
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae)
EXOSC5 exosome component 5
F12 coagulation factor XII (Hageman factor)
FAM216A family with sequence similarity 216, member A
FANCG Fanconi anemia, complementation group G
FANCI Fanconi anemia, complementation group I
FBL fibrillarin
FEN1 flap structure-specific endonuclease 1
FJX1 four jointed box 1 (Drosophila)
FOXM1 forkhead box M1
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GPSM2 G-protein signaling modulator 2
GUSBP11 glucuronidase, beta pseudogene 11
HELLS helicase, lymphoid-specific
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HMGB2 high mobility group box 2
HMMR hyaluronan-mediated motility receptor (RHAMM)
HOPX HOP homeobox
IFI16 interferon, gamma-inducible protein 16
IGFBP3 insulin-like growth factor binding protein 3
IGFBP7 insulin-like growth factor binding protein 7
IGL immunoglobulin lambda locus
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
KIAA0101 KIAA0101
KIF11 kinesin family member 11
KIF15 kinesin family member 15
KIF20A kinesin family member 20A
KIF2C kinesin family member 2C
LAMP5 lysosomal-associated membrane protein family, member 5
LIG1 ligase I, DNA, ATP-dependent
LMNB1 lamin B1
LY75 lymphocyte antigen 75
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MAN1A1 mannosidase, alpha, class 1A, member 1
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MCM7 minichromosome maintenance complex component 7
MELK maternal embryonic leucine zipper kinase
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAP1L1 nucleosome assembly protein 1-like 1
NAV3 neuron navigator 3
NDC80 NDC80 kinetochore complex component
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NKG7 natural killer cell granule protein 7
NMU neuromedin U
NOP56 NOP56 ribonucleoprotein
PA2G4 proliferation-associated 2G4, 38kDa
PABPC4 poly(A) binding protein, cytoplasmic 4 (inducible form)
PBK PDZ binding kinase
PCNA proliferating cell nuclear antigen
PLK2 polo-like kinase 2
PLS3 plastin 3
PRC1 protein regulator of cytokinesis 1
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PRR7 proline rich 7 (synaptic)
PSPH phosphoserine phosphatase
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTTG1 pituitary tumor-transforming 1
PUS7 pseudouridylate synthase 7 (putative)
RACGAP1 Rac GTPase activating protein 1
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RFC3 replication factor C (activator 1) 3, 38kDa
RGS5 regulator of G-protein signaling 5
RPL22 ribosomal protein L22
RRM2 ribonucleotide reductase M2
SPINK1 serine peptidase inhibitor, Kazal type 1
ST7 suppression of tumorigenicity 7
STMN1 stathmin 1
TMEM97 transmembrane protein 97
TMPO thymopoietin
TOP2A topoisomerase (DNA) II alpha 170kDa
TP53 tumor protein p53
TPX2 TPX2, microtubule-associated
TRIB1 tribbles pseudokinase 1
TRIP13 thyroid hormone receptor interactor 13
TRIP6 thyroid hormone receptor interactor 6
TSPAN12 tetraspanin 12
TTK TTK protein kinase
TYMS thymidylate synthetase
UBE2C ubiquitin-conjugating enzyme E2C
WASF1 WAS protein family, member 1
ZWINT ZW10 interacting kinetochore protein