BRD-K32501161_GBR 12909 dihydrochloride_HA1E_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

132 genes differentially expressed following the BRD-K32501161_GBR 12909 dihydrochloride_HA1E_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ABLIM1 actin binding LIM protein 1
ACAT2 acetyl-CoA acetyltransferase 2
ACTA2 actin, alpha 2, smooth muscle, aorta
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF4 activating transcription factor 4
C6ORF62 chromosome 6 open reading frame 62
CA1 carbonic anhydrase I
CARS cysteinyl-tRNA synthetase
CBS cystathionine-beta-synthase
CD52 CD52 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHGB chromogranin B
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLCA4 chloride channel accessory 4
CLIC5 chloride intracellular channel 5
CTSA cathepsin A
CYBB cytochrome b-245, beta polypeptide
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DPP4 dipeptidyl-peptidase 4
DUSP6 dual specificity phosphatase 6
EIF1 eukaryotic translation initiation factor 1
EIF4A1 eukaryotic translation initiation factor 4A1
EIF5A eukaryotic translation initiation factor 5A
FAS Fas cell surface death receptor
FST follistatin
GCH1 GTP cyclohydrolase 1
GDF15 growth differentiation factor 15
HMOX1 heme oxygenase 1
IFRD1 interferon-related developmental regulator 1
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
ITGA6 integrin, alpha 6
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
LTB lymphotoxin beta (TNF superfamily, member 3)
LY96 lymphocyte antigen 96
MARS methionyl-tRNA synthetase
MDK midkine (neurite growth-promoting factor 2)
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
N4BP2L2 NEDD4 binding protein 2-like 2
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NELL2 NEL-like 2 (chicken)
NPIPB3 nuclear pore complex interacting protein family, member B3
NT5DC2 5'-nucleotidase domain containing 2
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PHGDH phosphoglycerate dehydrogenase
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PLEKHM1 pleckstrin homology domain containing, family M (with RUN domain) member 1
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
POSTN periostin, osteoblast specific factor
PSAT1 phosphoserine aminotransferase 1
SCGB2A2 secretoglobin, family 2A, member 2
SGK1 serum/glucocorticoid regulated kinase 1
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC38A1 solute carrier family 38, member 1
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
STAP1 signal transducing adaptor family member 1
STC2 stanniocalcin 2
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TPP1 tripeptidyl peptidase I
TRIB3 tribbles pseudokinase 3
TSC22D3 TSC22 domain family, member 3
TXNRD1 thioredoxin reductase 1
VEGFA vascular endothelial growth factor A
XIST X inactive specific transcript (non-protein coding)
XPOT exportin, tRNA
ZNF83 zinc finger protein 83

decreased expression

Symbol Name
ACKR3 atypical chemokine receptor 3
ADA adenosine deaminase
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AFF1 AF4/FMR2 family, member 1
AHNAK2 AHNAK nucleoprotein 2
AK4 adenylate kinase 4
AOX1 aldehyde oxidase 1
APOD apolipoprotein D
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
BICC1 BicC family RNA binding protein 1
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CBR3 carbonyl reductase 3
CCL2 chemokine (C-C motif) ligand 2
CCNF cyclin F
CTSC cathepsin C
DEFB1 defensin, beta 1
DPT dermatopontin
EPB41L2 erythrocyte membrane protein band 4.1-like 2
FAM3C family with sequence similarity 3, member C
FHL1 four and a half LIM domains 1
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GPI glucose-6-phosphate isomerase
GSTM3 glutathione S-transferase mu 3 (brain)
HES1 hes family bHLH transcription factor 1
HSPB8 heat shock 22kDa protein 8
IGFBP3 insulin-like growth factor binding protein 3
KDM3A lysine (K)-specific demethylase 3A
MATN2 matrilin 2
MGP matrix Gla protein
MYRF myelin regulatory factor
NFIB nuclear factor I/B
NRN1 neuritin 1
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PGM1 phosphoglucomutase 1
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLAGL1 pleiomorphic adenoma gene-like 1
PROM1 prominin 1
PTGES prostaglandin E synthase
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RHOB ras homolog family member B
RNF167 ring finger protein 167
RPL37A ribosomal protein L37a
RPS11 ribosomal protein S11
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SORBS1 sorbin and SH3 domain containing 1
SOX4 SRY (sex determining region Y)-box 4
SPAG4 sperm associated antigen 4
SRPX sushi-repeat containing protein, X-linked
STC1 stanniocalcin 1
TGM2 transglutaminase 2
TIAM1 T-cell lymphoma invasion and metastasis 1
TMEM45A transmembrane protein 45A
TNS1 tensin 1
TPD52L1 tumor protein D52-like 1
TSPAN13 tetraspanin 13
TSPYL5 TSPY-like 5