BRD-K32010074_-666_HA1E_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

178 genes differentially expressed following the BRD-K32010074_-666_HA1E_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AGO2 argonaute RISC catalytic component 2
ANXA1 annexin A1
AP1S2 adaptor-related protein complex 1, sigma 2 subunit
ARID4B AT rich interactive domain 4B (RBP1-like)
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
BAG3 BCL2-associated athanogene 3
BAMBI BMP and activin membrane-bound inhibitor
BTG1 B-cell translocation gene 1, anti-proliferative
CCDC59 coiled-coil domain containing 59
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDK17 cyclin-dependent kinase 17
CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHD1 chromodomain helicase DNA binding protein 1
CHIC2 cysteine-rich hydrophobic domain 2
CKS2 CDC28 protein kinase regulatory subunit 2
CRYAB crystallin, alpha B
CSRP1 cysteine and glycine-rich protein 1
CTSH cathepsin H
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP1 dual specificity phosphatase 1
DUSP10 dual specificity phosphatase 10
DUSP2 dual specificity phosphatase 2
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EDN1 endothelin 1
EDNRB endothelin receptor type B
EGR1 early growth response 1
EGR2 early growth response 2
EGR3 early growth response 3
EIF5 eukaryotic translation initiation factor 5
ELL2 elongation factor, RNA polymerase II, 2
ELOVL5 ELOVL fatty acid elongase 5
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FBXO11 F-box protein 11
FOS FBJ murine osteosarcoma viral oncogene homolog
FOXO1 forkhead box O1
FRS2 fibroblast growth factor receptor substrate 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GATA2 GATA binding protein 2
GATA3 GATA binding protein 3
GDF15 growth differentiation factor 15
GFOD1 glucose-fructose oxidoreductase domain containing 1
GOLT1B golgi transport 1B
HBEGF heparin-binding EGF-like growth factor
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HES1 hes family bHLH transcription factor 1
HIST1H2BG histone cluster 1, H2bg
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA1A heat shock 70kDa protein 1A
HSPA2 heat shock 70kDa protein 2
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPB8 heat shock 22kDa protein 8
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPH1 heat shock 105kDa/110kDa protein 1
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IER2 immediate early response 2
IER5 immediate early response 5
IFI27 interferon, alpha-inducible protein 27
IFRD1 interferon-related developmental regulator 1
IRS2 insulin receptor substrate 2
ITM2A integral membrane protein 2A
JUNB jun B proto-oncogene
KLHL21 kelch-like family member 21
KLK11 kallikrein-related peptidase 11
KRT5 keratin 5, type II
LOC100505650 uncharacterized LOC100505650
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MBNL2 muscleblind-like splicing regulator 2
MCL1 myeloid cell leukemia 1
MSX1 msh homeobox 1
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1X metallothionein 1X
MT2A metallothionein 2A
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NR4A3 nuclear receptor subfamily 4, group A, member 3
NUPL1 nucleoporin like 1
PDGFA platelet-derived growth factor alpha polypeptide
PDLIM5 PDZ and LIM domain 5
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1
PLK2 polo-like kinase 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPARG peroxisome proliferator-activated receptor gamma
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha
PTN pleiotrophin
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RCAN1 regulator of calcineurin 1
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
RIOK3 RIO kinase 3
RNMT RNA (guanine-7-) methyltransferase
RYBP RING1 and YY1 binding protein
SAT1 spermidine/spermine N1-acetyltransferase 1
SEC24A SEC24 family member A
SFRP1 secreted frizzled-related protein 1
SIK1 salt-inducible kinase 1
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC38A2 solute carrier family 38, member 2
SOX4 SRY (sex determining region Y)-box 4
SOX9 SRY (sex determining region Y)-box 9
SPATS2L spermatogenesis associated, serine-rich 2-like
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TRBC1 T cell receptor beta constant 1
TRIB1 tribbles pseudokinase 1
TUFT1 tuftelin 1
UPP1 uridine phosphorylase 1
XBP1 X-box binding protein 1
YRDC yrdC N(6)-threonylcarbamoyltransferase domain containing
ZBTB10 zinc finger and BTB domain containing 10

decreased expression

Symbol Name
ACAT2 acetyl-CoA acetyltransferase 2
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
ANXA4 annexin A4
B3GNT1
BAD BCL2-associated agonist of cell death
CAPG capping protein (actin filament), gelsolin-like
CCNF cyclin F
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CLCA2 chloride channel accessory 2
CRIP2 cysteine-rich protein 2
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
DEPTOR DEP domain containing MTOR-interacting protein
DHRS1 dehydrogenase/reductase (SDR family) member 1
DMXL2 Dmx-like 2
F12 coagulation factor XII (Hageman factor)
FADS2 fatty acid desaturase 2
FHL1 four and a half LIM domains 1
FPGS folylpolyglutamate synthase
HIGD2A HIG1 hypoxia inducible domain family, member 2A
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
ITGA8 integrin, alpha 8
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
LGR4 leucine-rich repeat containing G protein-coupled receptor 4
LOXL1 lysyl oxidase-like 1
LTBP1 latent transforming growth factor beta binding protein 1
MAGEA3 melanoma antigen family A3
MEIS1 Meis homeobox 1
NUDCD3 NudC domain containing 3
PBX3 pre-B-cell leukemia homeobox 3
PCLO piccolo presynaptic cytomatrix protein
PPAP2B phosphatidic acid phosphatase type 2B
PRR7 proline rich 7 (synaptic)
PYGB phosphorylase, glycogen; brain
QPRT quinolinate phosphoribosyltransferase
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RNASE4 ribonuclease, RNase A family, 4
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SDC1 syndecan 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SOX11 SRY (sex determining region Y)-box 11
THY1 Thy-1 cell surface antigen
TNS1 tensin 1
TSPAN12 tetraspanin 12
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)