BRD-K31912990_-666_HT29_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

146 genes differentially expressed following the BRD-K31912990_-666_HT29_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ADAM12 ADAM metallopeptidase domain 12
ADM adrenomedullin
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
ARFGAP3 ADP-ribosylation factor GTPase activating protein 3
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARMCX3 armadillo repeat containing, X-linked 3
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
CARS cysteinyl-tRNA synthetase
CCNG2 cyclin G2
CD86 CD86 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
COL11A1 collagen, type XI, alpha 1
COL15A1 collagen, type XV, alpha 1
COL1A1 collagen, type I, alpha 1
COL5A2 collagen, type V, alpha 2
CREB3L2 cAMP responsive element binding protein 3-like 2
CTH cystathionine gamma-lyase
CYBB cytochrome b-245, beta polypeptide
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
EDEM1 ER degradation enhancer, mannosidase alpha-like 1
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
EIF5A eukaryotic translation initiation factor 5A
EVI2A ecotropic viral integration site 2A
FAM129A family with sequence similarity 129, member A
FICD FIC domain containing
FOXO3 forkhead box O3
FZD6 frizzled class receptor 6
GADD45A growth arrest and DNA-damage-inducible, alpha
GARS glycyl-tRNA synthetase
GATA6 GATA binding protein 6
GDF15 growth differentiation factor 15
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GLRX glutaredoxin (thioltransferase)
GOT1 glutamic-oxaloacetic transaminase 1, soluble
H1F0 H1 histone family, member 0
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSPA13 heat shock protein 70kDa family, member 13
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HYOU1 hypoxia up-regulated 1
IFRD1 interferon-related developmental regulator 1
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
IL6ST interleukin 6 signal transducer
INSIG1 insulin induced gene 1
JUN jun proto-oncogene
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2
KYNU kynureninase
LDLR low density lipoprotein receptor
LGALS2 lectin, galactoside-binding, soluble, 2
LPIN1 lipin 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAGT1 magnesium transporter 1
MARS methionyl-tRNA synthetase
MBNL2 muscleblind-like splicing regulator 2
MOCOS molybdenum cofactor sulfurase
MSMO1 methylsterol monooxygenase 1
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MTSS1 metastasis suppressor 1
NAMPT nicotinamide phosphoribosyltransferase
NANS N-acetylneuraminic acid synthase
NFIL3 nuclear factor, interleukin 3 regulated
NUCB2 nucleobindin 2
NUPR1 nuclear protein, transcriptional regulator, 1
PHGDH phosphoglycerate dehydrogenase
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPAP2B phosphatidic acid phosphatase type 2B
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PSAT1 phosphoserine aminotransferase 1
PSPH phosphoserine phosphatase
PYROXD1 pyridine nucleotide-disulphide oxidoreductase domain 1
RCAN1 regulator of calcineurin 1
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RIOK3 RIO kinase 3
SAR1B secretion associated, Ras related GTPase 1B
SARS seryl-tRNA synthetase
SAT1 spermidine/spermine N1-acetyltransferase 1
SEC24D SEC24 family member D
SEC63 SEC63 homolog (S. cerevisiae)
SEL1L sel-1 suppressor of lin-12-like (C. elegans)
SERINC5 serine incorporator 5
SERP1 stress-associated endoplasmic reticulum protein 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC33A1 solute carrier family 33 (acetyl-CoA transporter), member 1
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SOX9 SRY (sex determining region Y)-box 9
SQLE squalene epoxidase
SQSTM1 sequestosome 1
SSR1 signal sequence receptor, alpha
SULF1 sulfatase 1
TGFBI transforming growth factor, beta-induced, 68kDa
THBS1 thrombospondin 1
TMED5 transmembrane emp24 protein transport domain containing 5
TRIB3 tribbles pseudokinase 3
TSC22D3 TSC22 domain family, member 3
TTC37 tetratricopeptide repeat domain 37
TVP23B trans-golgi network vesicle protein 23 homolog B (S. cerevisiae)
UFL1 UFM1-specific ligase 1
UFM1 ubiquitin-fold modifier 1
VEGFA vascular endothelial growth factor A
WARS tryptophanyl-tRNA synthetase
WIPI1 WD repeat domain, phosphoinositide interacting 1
XBP1 X-box binding protein 1
XPOT exportin, tRNA
YARS tyrosyl-tRNA synthetase

decreased expression

Symbol Name
A2M alpha-2-macroglobulin
ABAT 4-aminobutyrate aminotransferase
ADIRF adipogenesis regulatory factor
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
ATP5G2 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C2 (subunit 9)
CD24 CD24 molecule
CDC25A cell division cycle 25A
CLEC11A C-type lectin domain family 11, member A
FABP5 fatty acid binding protein 5 (psoriasis-associated)
GATA2 GATA binding protein 2
GINS1 GINS complex subunit 1 (Psf1 homolog)
GNAS GNAS complex locus
HSPA8 heat shock 70kDa protein 8
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGLL1 immunoglobulin lambda-like polypeptide 1
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
LIG1 ligase I, DNA, ATP-dependent
MRPS16 mitochondrial ribosomal protein S16
NOP56 NOP56 ribonucleoprotein
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
RBP1 retinol binding protein 1, cellular
RGS2 regulator of G-protein signaling 2
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SCG5 secretogranin V
TMEM109 transmembrane protein 109