BRD-K31912990_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

99 genes differentially expressed following the BRD-K31912990_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AARS alanyl-tRNA synthetase
ACBD3 acyl-CoA binding domain containing 3
ACKR3 atypical chemokine receptor 3
ALDH6A1 aldehyde dehydrogenase 6 family, member A1
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARMCX1 armadillo repeat containing, X-linked 1
ARMCX3 armadillo repeat containing, X-linked 3
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATHL1 ATH1, acid trehalase-like 1 (yeast)
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
BTG2 BTG family, member 2
BZW2 basic leucine zipper and W2 domains 2
CALR calreticulin
CALU calumenin
CCR7 chemokine (C-C motif) receptor 7
CDK2AP2 cyclin-dependent kinase 2 associated protein 2
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CPM carboxypeptidase M
CRELD2 cysteine-rich with EGF-like domains 2
DDIT3 DNA-damage-inducible transcript 3
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
EDEM1 ER degradation enhancer, mannosidase alpha-like 1
F3 coagulation factor III (thromboplastin, tissue factor)
FADS1 fatty acid desaturase 1
FAM114A1 family with sequence similarity 114, member A1
FKBP11 FK506 binding protein 11, 19 kDa
GDF15 growth differentiation factor 15
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GLRX glutaredoxin (thioltransferase)
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HYOU1 hypoxia up-regulated 1
INSIG1 insulin induced gene 1
IRS2 insulin receptor substrate 2
JCHAIN joining chain of multimeric IgA and IgM
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
LDLR low density lipoprotein receptor
MANF mesencephalic astrocyte-derived neurotrophic factor
MBNL2 muscleblind-like splicing regulator 2
MSMO1 methylsterol monooxygenase 1
NUCB2 nucleobindin 2
PDGFRL platelet-derived growth factor receptor-like
PDIA3 protein disulfide isomerase family A, member 3
PDIA4 protein disulfide isomerase family A, member 4
PPIB peptidylprolyl isomerase B (cyclophilin B)
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SDF2L1 stromal cell-derived factor 2-like 1
SEC24A SEC24 family member A
SEC24D SEC24 family member D
SEC61G Sec61 gamma subunit
SEL1L sel-1 suppressor of lin-12-like (C. elegans)
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SQLE squalene epoxidase
STK26 serine/threonine protein kinase 26
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast)
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNFAIP8 tumor necrosis factor, alpha-induced protein 8
TNNT1 troponin T type 1 (skeletal, slow)
TXNIP thioredoxin interacting protein
UGDH UDP-glucose 6-dehydrogenase
VEGFA vascular endothelial growth factor A
WARS tryptophanyl-tRNA synthetase
XBP1 X-box binding protein 1

decreased expression

Symbol Name
ADD3 adducin 3 (gamma)
AKR1C2 aldo-keto reductase family 1, member C2
AREG amphiregulin
ATG3 autophagy related 3
CADM1 cell adhesion molecule 1
CCND1 cyclin D1
CD24 CD24 molecule
COL1A1 collagen, type I, alpha 1
CXADR coxsackie virus and adenovirus receptor
DPYSL3 dihydropyrimidinase-like 3
F2RL1 coagulation factor II (thrombin) receptor-like 1
GJA1 gap junction protein, alpha 1, 43kDa
GRB14 growth factor receptor-bound protein 14
GRWD1 glutamate-rich WD repeat containing 1
IGFBP7 insulin-like growth factor binding protein 7
LAPTM4B lysosomal protein transmembrane 4 beta
MAB21L2 mab-21-like 2 (C. elegans)
MAP1B microtubule-associated protein 1B
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
OLFM4 olfactomedin 4
PRKD3 protein kinase D3
S100A10 S100 calcium binding protein A10
S100A7 S100 calcium binding protein A7
SCG2 secretogranin II
SEPP1 selenoprotein P, plasma, 1
TPM1 tropomyosin 1 (alpha)
TSPAN8 tetraspanin 8
TUBB2A tubulin, beta 2A class IIa