BRD-K31843556_-666_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

66 genes differentially expressed following the BRD-K31843556_-666_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACAT2 acetyl-CoA acetyltransferase 2
AGR2 anterior gradient 2
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CEMIP cell migration inducing protein, hyaluronan binding
CST1 cystatin SN
CST4 cystatin S
CXCL5 chemokine (C-X-C motif) ligand 5
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
FABP4 fatty acid binding protein 4, adipocyte
FADS1 fatty acid desaturase 1
FADS2 fatty acid desaturase 2
FBXL12 F-box and leucine-rich repeat protein 12
FDPS farnesyl diphosphate synthase
GPX2 glutathione peroxidase 2
GREM1 gremlin 1, DAN family BMP antagonist
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
IDI1 isopentenyl-diphosphate delta isomerase 1
INSIG1 insulin induced gene 1
KRT81 keratin 81, type II
LDLR low density lipoprotein receptor
LMCD1 LIM and cysteine-rich domains 1
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
MALL mal, T-cell differentiation protein-like
MSMO1 methylsterol monooxygenase 1
MTCL1 microtubule crosslinking factor 1
NEBL nebulette
NUCB2 nucleobindin 2
RPL37A ribosomal protein L37a
S100P S100 calcium binding protein P
SAMD4A sterile alpha motif domain containing 4A
SC5D sterol-C5-desaturase
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCGB2A1 secretoglobin, family 2A, member 1
SFN stratifin
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SQLE squalene epoxidase
SWAP70 SWAP switching B-cell complex 70kDa subunit
TMEM41B transmembrane protein 41B
TRIM2 tripartite motif containing 2
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
VIM vimentin
ZBTB18 zinc finger and BTB domain containing 18

decreased expression

Symbol Name
C1QB complement component 1, q subcomponent, B chain
EPHA3 EPH receptor A3
F2R coagulation factor II (thrombin) receptor
FAM3C family with sequence similarity 3, member C
GADD45B growth arrest and DNA-damage-inducible, beta
MCOLN1 mucolipin 1
MT1E metallothionein 1E
MT1X metallothionein 1X
MT2A metallothionein 2A
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
ODC1 ornithine decarboxylase 1
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2