BRD-K31706415_-666_HA1E_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

114 genes differentially expressed following the BRD-K31706415_-666_HA1E_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AARS alanyl-tRNA synthetase
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ADRB2 adrenoceptor beta 2, surface
AMIGO2 adhesion molecule with Ig-like domain 2
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
C6ORF48 chromosome 6 open reading frame 48
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CCND2 cyclin D2
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CGRRF1 cell growth regulator with ring finger domain 1
CNIH3 cornichon family AMPA receptor auxiliary protein 3
CTSH cathepsin H
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DKK1 dickkopf WNT signaling pathway inhibitor 1
DPP4 dipeptidyl-peptidase 4
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EPCAM epithelial cell adhesion molecule
ETV5 ets variant 5
FAM129A family with sequence similarity 129, member A
FBP1 fructose-1,6-bisphosphatase 1
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GDF15 growth differentiation factor 15
GLS glutaminase
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMOX1 heme oxygenase 1
HRASLS HRAS-like suppressor
KIF14 kinesin family member 14
KRT18 keratin 18, type I
LGALS3 lectin, galactoside-binding, soluble, 3
MAPK13 mitogen-activated protein kinase 13
MGP matrix Gla protein
MT1X metallothionein 1X
MT2A metallothionein 2A
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
PEG10 paternally expressed 10
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLAT plasminogen activator, tissue
PLSCR3 phospholipid scramblase 3
PNMAL1 paraneoplastic Ma antigen family-like 1
PSAT1 phosphoserine aminotransferase 1
PSPH phosphoserine phosphatase
PTPRE protein tyrosine phosphatase, receptor type, E
QSOX1 quiescin Q6 sulfhydryl oxidase 1
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SGCE sarcoglycan, epsilon
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SPATS2L spermatogenesis associated, serine-rich 2-like
SRC SRC proto-oncogene, non-receptor tyrosine kinase
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
STK39 serine threonine kinase 39
SYT11 synaptotagmin XI
TEX10 testis expressed 10
TGFA transforming growth factor, alpha
TM4SF1 transmembrane 4 L six family member 1
TMC5 transmembrane channel-like 5
TRIB3 tribbles pseudokinase 3
TSC22D3 TSC22 domain family, member 3
TXNIP thioredoxin interacting protein
ZNF586 zinc finger protein 586

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ADM adrenomedullin
APOL1 apolipoprotein L, 1
AUTS2 autism susceptibility candidate 2
CA12 carbonic anhydrase XII
CA2 carbonic anhydrase II
CD200 CD200 molecule
CKB creatine kinase, brain
CLIC4 chloride intracellular channel 4
CLIP3 CAP-GLY domain containing linker protein 3
CSRP1 cysteine and glycine-rich protein 1
CSRP2 cysteine and glycine-rich protein 2
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa
CXCL8 chemokine (C-X-C motif) ligand 8
DPYSL3 dihydropyrimidinase-like 3
EDN1 endothelin 1
EGF epidermal growth factor
ERBB2 erb-b2 receptor tyrosine kinase 2
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FGFR2 fibroblast growth factor receptor 2
GBP1 guanylate binding protein 1, interferon-inducible
GSTM3 glutathione S-transferase mu 3 (brain)
HEATR1 HEAT repeat containing 1
HIST1H2BD histone cluster 1, H2bd
HMG20B high mobility group 20B
HSPA2 heat shock 70kDa protein 2
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
MAP7 microtubule-associated protein 7
MEIS2 Meis homeobox 2
NELL2 NEL-like 2 (chicken)
NOX1 NADPH oxidase 1
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PECAM1 platelet/endothelial cell adhesion molecule 1
PLAGL1 pleiomorphic adenoma gene-like 1
RGS5 regulator of G-protein signaling 5
SDC2 syndecan 2
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SGK1 serum/glucocorticoid regulated kinase 1
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SOD2 superoxide dismutase 2, mitochondrial
SORD sorbitol dehydrogenase
TFF1 trefoil factor 1
TMEM45A transmembrane protein 45A
TMEM47 transmembrane protein 47
VCAM1 vascular cell adhesion molecule 1