BRD-K31706415_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

148 genes differentially expressed following the BRD-K31706415_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ACTA1 actin, alpha 1, skeletal muscle
ARG2 arginase 2
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARMCX3 armadillo repeat containing, X-linked 3
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
BCAT1 branched chain amino-acid transaminase 1, cytosolic
C6ORF48 chromosome 6 open reading frame 48
CARS cysteinyl-tRNA synthetase
CBS cystathionine-beta-synthase
CCNA1 cyclin A1
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CEMIP cell migration inducing protein, hyaluronan binding
CFD complement factor D (adipsin)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHIC2 cysteine-rich hydrophobic domain 2
CSGALNACT2 chondroitin sulfate N-acetylgalactosaminyltransferase 2
CTH cystathionine gamma-lyase
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DEPTOR DEP domain containing MTOR-interacting protein
DHRS2 dehydrogenase/reductase (SDR family) member 2
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
EGR1 early growth response 1
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa
FAM129A family with sequence similarity 129, member A
FHL2 four and a half LIM domains 2
FKBP11 FK506 binding protein 11, 19 kDa
GADD45A growth arrest and DNA-damage-inducible, alpha
GARS glycyl-tRNA synthetase
GATA6 GATA binding protein 6
GDF15 growth differentiation factor 15
GLRX glutaredoxin (thioltransferase)
GOT1 glutamic-oxaloacetic transaminase 1, soluble
GTPBP2 GTP binding protein 2
H1F0 H1 histone family, member 0
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMOX1 heme oxygenase 1
HSPA13 heat shock protein 70kDa family, member 13
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HYOU1 hypoxia up-regulated 1
IARS isoleucyl-tRNA synthetase
ICAM2 intercellular adhesion molecule 2
IER2 immediate early response 2
IFRD1 interferon-related developmental regulator 1
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IL1A interleukin 1, alpha
INHBE inhibin, beta E
ISG20 interferon stimulated exonuclease gene 20kDa
JCHAIN joining chain of multimeric IgA and IgM
JUN jun proto-oncogene
KLF2 Kruppel-like factor 2
KLHL41 kelch-like family member 41
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MARS methionyl-tRNA synthetase
MFSD10 major facilitator superfamily domain containing 10
MOCOS molybdenum cofactor sulfurase
NFIL3 nuclear factor, interleukin 3 regulated
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A3 nuclear receptor subfamily 4, group A, member 3
NUPR1 nuclear protein, transcriptional regulator, 1
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDE4DIP phosphodiesterase 4D interacting protein
PHGDH phosphoglycerate dehydrogenase
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PSAT1 phosphoserine aminotransferase 1
PSPH phosphoserine phosphatase
PTP4A1 protein tyrosine phosphatase type IVA, member 1
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
S100P S100 calcium binding protein P
SARS seryl-tRNA synthetase
SCUBE2 signal peptide, CUB domain, EGF-like 2
SDF2L1 stromal cell-derived factor 2-like 1
SEL1L sel-1 suppressor of lin-12-like (C. elegans)
SELE selectin E
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC16A6 solute carrier family 16, member 6
SLC38A1 solute carrier family 38, member 1
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
STC2 stanniocalcin 2
TARS threonyl-tRNA synthetase
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TP53 tumor protein p53
TTN titin
UBE2J1 ubiquitin-conjugating enzyme E2, J1
VEGFA vascular endothelial growth factor A
WARS tryptophanyl-tRNA synthetase
XBP1 X-box binding protein 1
XPOT exportin, tRNA
YARS tyrosyl-tRNA synthetase

decreased expression

Symbol Name
ADI1 acireductone dioxygenase 1
ASH2L ash2 (absent, small, or homeotic)-like (Drosophila)
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4
BCL6 B-cell CLL/lymphoma 6
BPHL biphenyl hydrolase-like (serine hydrolase)
C1R complement component 1, r subcomponent
C1RL complement component 1, r subcomponent-like
CA12 carbonic anhydrase XII
CD14 CD14 molecule
CD163 CD163 molecule
CENPE centromere protein E, 312kDa
CFI complement factor I
CTSC cathepsin C
CXCL14 chemokine (C-X-C motif) ligand 14
DDHD2 DDHD domain containing 2
F13A1 coagulation factor XIII, A1 polypeptide
FAM13A family with sequence similarity 13, member A
GBP2 guanylate binding protein 2, interferon-inducible
GSTA1 glutathione S-transferase alpha 1
H3F3B H3 histone, family 3B (H3.3B)
HSD11B2 hydroxysteroid (11-beta) dehydrogenase 2
ICMT isoprenylcysteine carboxyl methyltransferase
IGF1 insulin-like growth factor 1 (somatomedin C)
KRT6B keratin 6B, type II
LAP3 leucine aminopeptidase 3
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MSH6 mutS homolog 6
NELL2 NEL-like 2 (chicken)
NOTCH2 notch 2
PCCA propionyl CoA carboxylase, alpha polypeptide
PERP PERP, TP53 apoptosis effector
PI3 peptidase inhibitor 3, skin-derived
PPP2R1B protein phosphatase 2, regulatory subunit A, beta
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RBPJ recombination signal binding protein for immunoglobulin kappa J region
SEPP1 selenoprotein P, plasma, 1
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPRR1A small proline-rich protein 1A
SPRR1B small proline-rich protein 1B
TCF4 transcription factor 4
TMEM45A transmembrane protein 45A
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
VSIG4 V-set and immunoglobulin domain containing 4
XIST X inactive specific transcript (non-protein coding)
ZNF185 zinc finger protein 185 (LIM domain)