BRD-K31542390_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

94 genes differentially expressed following the BRD-K31542390_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ADD3 adducin 3 (gamma)
AKR1C3 aldo-keto reductase family 1, member C3
APLP2 amyloid beta (A4) precursor-like protein 2
BTG3 BTG family, member 3
CADM1 cell adhesion molecule 1
CCNE2 cyclin E2
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CHGB chromogranin B
COL6A1 collagen, type VI, alpha 1
COL9A3 collagen, type IX, alpha 3
CTTN cortactin
CXADR coxsackie virus and adenovirus receptor
DFNA5 deafness, autosomal dominant 5
EXPH5 exophilin 5
FABP4 fatty acid binding protein 4, adipocyte
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAS Fas cell surface death receptor
FOSL1 FOS-like antigen 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GAGE3 G antigen 3
GNAS GNAS complex locus
GPER1 G protein-coupled estrogen receptor 1
GPM6A glycoprotein M6A
GRB7 growth factor receptor-bound protein 7
H1F0 H1 histone family, member 0
HBB hemoglobin, beta
KRT18 keratin 18, type I
LOX lysyl oxidase
MAOA monoamine oxidase A
MAP7 microtubule-associated protein 7
NMU neuromedin U
NUPR1 nuclear protein, transcriptional regulator, 1
PFKL phosphofructokinase, liver
PPL periplakin
REEP1 receptor accessory protein 1
REG1A regenerating islet-derived 1 alpha
REG3A regenerating islet-derived 3 alpha
RRAGD Ras-related GTP binding D
SCGB2A1 secretoglobin, family 2A, member 1
SDC2 syndecan 2
SDC4 syndecan 4
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SESN1 sestrin 1
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SPARCL1 SPARC-like 1 (hevin)
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
TIMP3 TIMP metallopeptidase inhibitor 3
TTC3 tetratricopeptide repeat domain 3
TXNIP thioredoxin interacting protein
TYMS thymidylate synthetase

decreased expression

Symbol Name
ARID1A AT rich interactive domain 1A (SWI-like)
ATF1 activating transcription factor 1
AZGP1 alpha-2-glycoprotein 1, zinc-binding
CA12 carbonic anhydrase XII
CENPF centromere protein F, 350/400kDa
CHD7 chromodomain helicase DNA binding protein 7
CHSY1 chondroitin sulfate synthase 1
CKS2 CDC28 protein kinase regulatory subunit 2
COL5A1 collagen, type V, alpha 1
CXCL12 chemokine (C-X-C motif) ligand 12
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DMXL2 Dmx-like 2
EIF5 eukaryotic translation initiation factor 5
GATA3 GATA binding protein 3
HES1 hes family bHLH transcription factor 1
IER3 immediate early response 3
IGF1R insulin-like growth factor 1 receptor
JMJD6 jumonji domain containing 6
KIF14 kinesin family member 14
MARCKS myristoylated alanine-rich protein kinase C substrate
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYH10 myosin, heavy chain 10, non-muscle
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NPY1R neuropeptide Y receptor Y1
NR2F2 nuclear receptor subfamily 2, group F, member 2
PDE4B phosphodiesterase 4B, cAMP-specific
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PLK1 polo-like kinase 1
PLK2 polo-like kinase 2
PRKCA protein kinase C, alpha
PSRC1 proline/serine-rich coiled-coil 1
PYCARD PYD and CARD domain containing
RGS1 regulator of G-protein signaling 1
SMAD3 SMAD family member 3
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TBL1X transducin (beta)-like 1X-linked
TCL1A T-cell leukemia/lymphoma 1A
TFPI2 tissue factor pathway inhibitor 2
THBS1 thrombospondin 1
TOP2A topoisomerase (DNA) II alpha 170kDa