BRD-K31542390_-666_HT29_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

99 genes differentially expressed following the BRD-K31542390_-666_HT29_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
AEBP1 AE binding protein 1
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALB albumin
ALOX5 arachidonate 5-lipoxygenase
AMDHD2 amidohydrolase domain containing 2
BTBD3 BTB (POZ) domain containing 3
CCNE2 cyclin E2
CD36 CD36 molecule (thrombospondin receptor)
CD59 CD59 molecule, complement regulatory protein
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CIRBP cold inducible RNA binding protein
COL11A1 collagen, type XI, alpha 1
CPA3 carboxypeptidase A3 (mast cell)
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CYB5R1 cytochrome b5 reductase 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUSP1 dual specificity phosphatase 1
DUSP6 dual specificity phosphatase 6
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FXYD3 FXYD domain containing ion transport regulator 3
GNAS GNAS complex locus
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
LEF1 lymphoid enhancer-binding factor 1
LMNA lamin A/C
MGP matrix Gla protein
MSH6 mutS homolog 6
PI3 peptidase inhibitor 3, skin-derived
PSAP prosaposin
PTPN6 protein tyrosine phosphatase, non-receptor type 6
RFC2 replication factor C (activator 1) 2, 40kDa
RRAGD Ras-related GTP binding D
RUFY3 RUN and FYVE domain containing 3
SFN stratifin
TMEM45A transmembrane protein 45A
TMEM5 transmembrane protein 5
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TPPP3 tubulin polymerization-promoting protein family member 3
TYMP thymidine phosphorylase

decreased expression

Symbol Name
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATF1 activating transcription factor 1
AURKA aurora kinase A
AXIN1 axin 1
BASP1 brain abundant, membrane attached signal protein 1
BTG1 B-cell translocation gene 1, anti-proliferative
C6ORF62 chromosome 6 open reading frame 62
CAV1 caveolin 1, caveolae protein, 22kDa
CCND2 cyclin D2
CENPA centromere protein A
CENPE centromere protein E, 312kDa
CENPF centromere protein F, 350/400kDa
CIT citron rho-interacting serine/threonine kinase
CKS2 CDC28 protein kinase regulatory subunit 2
COL4A5 collagen, type IV, alpha 5
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
EGFR epidermal growth factor receptor
EREG epiregulin
ESRP1 epithelial splicing regulatory protein 1
EXT1 exostosin glycosyltransferase 1
FAM193A family with sequence similarity 193, member A
FCGBP Fc fragment of IgG binding protein
FHOD3 formin homology 2 domain containing 3
GPSM2 G-protein signaling modulator 2
HOXA10 homeobox A10
INTS3 integrator complex subunit 3
LAMB1 laminin, beta 1
LCN2 lipocalin 2
LPAR1 lysophosphatidic acid receptor 1
MET MET proto-oncogene, receptor tyrosine kinase
NR2F2 nuclear receptor subfamily 2, group F, member 2
NRIP1 nuclear receptor interacting protein 1
NRP1 neuropilin 1
OGT O-linked N-acetylglucosamine (GlcNAc) transferase
OLFM4 olfactomedin 4
PAMR1 peptidase domain containing associated with muscle regeneration 1
PCSK1 proprotein convertase subtilisin/kexin type 1
PDGFD platelet derived growth factor D
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PHLDA1 pleckstrin homology-like domain, family A, member 1
PSRC1 proline/serine-rich coiled-coil 1
PTCH1 patched 1
RAD21 RAD21 homolog (S. pombe)
RGS1 regulator of G-protein signaling 1
RNF4 ring finger protein 4
RREB1 ras responsive element binding protein 1
SOX4 SRY (sex determining region Y)-box 4
TFPI2 tissue factor pathway inhibitor 2
TOP2A topoisomerase (DNA) II alpha 170kDa
TOX3 TOX high mobility group box family member 3
UBE3C ubiquitin protein ligase E3C
ZMYND8 zinc finger, MYND-type containing 8
ZNF217 zinc finger protein 217