BRD-K31342827_GF 109203X_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

154 genes differentially expressed following the BRD-K31342827_GF 109203X_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACTA1 actin, alpha 1, skeletal muscle
ADO 2-aminoethanethiol (cysteamine) dioxygenase
ANXA4 annexin A4
ANXA6 annexin A6
ASS1 argininosuccinate synthase 1
ATP1A1 ATPase, Na+/K+ transporting, alpha 1 polypeptide
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
BCAT1 branched chain amino-acid transaminase 1, cytosolic
BMP4 bone morphogenetic protein 4
CA2 carbonic anhydrase II
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CFB complement factor B
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CKM creatine kinase, muscle
CLU clusterin
CP ceruloplasmin (ferroxidase)
CSRP3 cysteine and glycine-rich protein 3 (cardiac LIM protein)
CXADR coxsackie virus and adenovirus receptor
DDB2 damage-specific DNA binding protein 2, 48kDa
DES desmin
DHCR24 24-dehydrocholesterol reductase
DPYSL3 dihydropyrimidinase-like 3
DUSP3 dual specificity phosphatase 3
FAS Fas cell surface death receptor
FHL1 four and a half LIM domains 1
GAL galanin/GMAP prepropeptide
GAS1 growth arrest-specific 1
GAS6 growth arrest-specific 6
GJA1 gap junction protein, alpha 1, 43kDa
GLUL glutamate-ammonia ligase
HEBP1 heme binding protein 1
HES1 hes family bHLH transcription factor 1
IL1R2 interleukin 1 receptor, type II
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
INSIG1 insulin induced gene 1
KAZN kazrin, periplakin interacting protein
KIAA0125 KIAA0125
KLHL41 kelch-like family member 41
LAMP5 lysosomal-associated membrane protein family, member 5
MEIS1 Meis homeobox 1
MN1 meningioma (disrupted in balanced translocation) 1
MXRA7 matrix-remodelling associated 7
MYBPC1 myosin binding protein C, slow type
MYH2 myosin, heavy chain 2, skeletal muscle, adult
MYL1 myosin, light chain 1, alkali; skeletal, fast
MYL2 myosin, light chain 2, regulatory, cardiac, slow
NEB nebulin
NPC2 Niemann-Pick disease, type C2
NUPR1 nuclear protein, transcriptional regulator, 1
OBSL1 obscurin-like 1
PCP4 Purkinje cell protein 4
PDE4DIP phosphodiesterase 4D interacting protein
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PNMAL1 paraneoplastic Ma antigen family-like 1
PRKCB protein kinase C, beta
RBP1 retinol binding protein 1, cellular
RPL22 ribosomal protein L22
RRAGD Ras-related GTP binding D
RSL1D1 ribosomal L1 domain containing 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCG2 secretogranin II
SCG5 secretogranin V
SCML1 sex comb on midleg-like 1 (Drosophila)
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SLN sarcolipin
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SSPN sarcospan
STC2 stanniocalcin 2
STMN2 stathmin 2
TFRC transferrin receptor
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMOD1 tropomodulin 1
TNNC1 troponin C type 1 (slow)
TNNI1 troponin I type 1 (skeletal, slow)
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast)
TPM2 tropomyosin 2 (beta)
TTN titin
ZFP36L2 ZFP36 ring finger protein-like 2

decreased expression

Symbol Name
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
AQP3 aquaporin 3 (Gill blood group)
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
BAG3 BCL2-associated athanogene 3
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BPHL biphenyl hydrolase-like (serine hydrolase)
BPTF bromodomain PHD finger transcription factor
CD24 CD24 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDH19 cadherin 19, type 2
CDKN2A cyclin-dependent kinase inhibitor 2A
CLDN3 claudin 3
COL1A2 collagen, type I, alpha 2
COL6A3 collagen, type VI, alpha 3
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CTGF connective tissue growth factor
CTSC cathepsin C
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DCN decorin
ERBB3 erb-b2 receptor tyrosine kinase 3
ETV1 ets variant 1
EVI2A ecotropic viral integration site 2A
GLRX glutaredoxin (thioltransferase)
GULP1 GULP, engulfment adaptor PTB domain containing 1
HN1 hematological and neurological expressed 1
HOXB2 homeobox B2
HSPA1A heat shock 70kDa protein 1A
IER3 immediate early response 3
IGFBP3 insulin-like growth factor binding protein 3
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
ITGA6 integrin, alpha 6
KIF14 kinesin family member 14
KRT15 keratin 15, type I
LAPTM5 lysosomal protein transmembrane 5
LPAR6 lysophosphatidic acid receptor 6
MIA melanoma inhibitory activity
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MME membrane metallo-endopeptidase
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NTS neurotensin
PARN poly(A)-specific ribonuclease
PCCB propionyl CoA carboxylase, beta polypeptide
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PLAUR plasminogen activator, urokinase receptor
PLIN2 perilipin 2
PPARG peroxisome proliferator-activated receptor gamma
QPCT glutaminyl-peptide cyclotransferase
RGS1 regulator of G-protein signaling 1
RRM2 ribonucleotide reductase M2
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SGK1 serum/glucocorticoid regulated kinase 1
SLC16A4 solute carrier family 16, member 4
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SMAD3 SMAD family member 3
SNX10 sorting nexin 10
SOX10 SRY (sex determining region Y)-box 10
SRGN serglycin
SRI sorcin
STMN1 stathmin 1
STX1A syntaxin 1A (brain)
TARP TCR gamma alternate reading frame protein
TCF4 transcription factor 4
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TCTA T-cell leukemia translocation altered
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
THBS1 thrombospondin 1
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM2 transmembrane protein 2
TXNRD1 thioredoxin reductase 1
UPK1B uroplakin 1B
VAMP8 vesicle-associated membrane protein 8
WDFY3 WD repeat and FYVE domain containing 3
ZIC1 Zic family member 1