BRD-K31238592_Devazepide_HCC515_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

100 genes differentially expressed following the BRD-K31238592_Devazepide_HCC515_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AMIGO2 adhesion molecule with Ig-like domain 2
ASPH aspartate beta-hydroxylase
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BLVRB biliverdin reductase B
CD9 CD9 molecule
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
F12 coagulation factor XII (Hageman factor)
FXYD3 FXYD domain containing ion transport regulator 3
GCLC glutamate-cysteine ligase, catalytic subunit
GLRX glutaredoxin (thioltransferase)
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
HOPX HOP homeobox
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
ITGA6 integrin, alpha 6
KIAA1033 KIAA1033
LYPD3 LY6/PLAUR domain containing 3
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAOA monoamine oxidase A
MAP1B microtubule-associated protein 1B
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
NR1H2 nuclear receptor subfamily 1, group H, member 2
PDZK1IP1 PDZK1 interacting protein 1
PIR pirin (iron-binding nuclear protein)
PLIN2 perilipin 2
PON3 paraoxonase 3
PSAP prosaposin
RAP1GAP RAP1 GTPase activating protein
SCGB2A2 secretoglobin, family 2A, member 2
STAM signal transducing adaptor molecule (SH3 domain and ITAM motif) 1
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)

decreased expression

Symbol Name
AGR2 anterior gradient 2
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1
AURKA aurora kinase A
AURKB aurora kinase B
AUTS2 autism susceptibility candidate 2
BIRC5 baculoviral IAP repeat containing 5
BRCA1 breast cancer 1, early onset
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CCNA2 cyclin A2
CCNF cyclin F
CD24 CD24 molecule
CDC42 cell division cycle 42
CDC7 cell division cycle 7
CDK1 cyclin-dependent kinase 1
CENPA centromere protein A
CIT citron rho-interacting serine/threonine kinase
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CX3CR1 chemokine (C-X3-C motif) receptor 1
DCK deoxycytidine kinase
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
ELN elastin
EPHA3 EPH receptor A3
FGFR3 fibroblast growth factor receptor 3
FLRT2 fibronectin leucine rich transmembrane protein 2
FOS FBJ murine osteosarcoma viral oncogene homolog
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
HES1 hes family bHLH transcription factor 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IGF1 insulin-like growth factor 1 (somatomedin C)
IGFBP4 insulin-like growth factor binding protein 4
IGFBP7 insulin-like growth factor binding protein 7
ITGB1BP1 integrin beta 1 binding protein 1
JCHAIN joining chain of multimeric IgA and IgM
KIF11 kinesin family member 11
KIF18B kinesin family member 18B
KIF2C kinesin family member 2C
LUM lumican
MARCKS myristoylated alanine-rich protein kinase C substrate
MCM4 minichromosome maintenance complex component 4
METTL7A methyltransferase like 7A
MYH10 myosin, heavy chain 10, non-muscle
NGRN neugrin, neurite outgrowth associated
NUSAP1 nucleolar and spindle associated protein 1
PCDH9 protocadherin 9
PLK1 polo-like kinase 1
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PXMP2 peroxisomal membrane protein 2, 22kDa
RFC2 replication factor C (activator 1) 2, 40kDa
RFC5 replication factor C (activator 1) 5, 36.5kDa
SGCB sarcoglycan, beta (43kDa dystrophin-associated glycoprotein)
SPON1 spondin 1, extracellular matrix protein
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACC3 transforming, acidic coiled-coil containing protein 3
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TIMELESS timeless circadian clock
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast)
TMEM97 transmembrane protein 97
TMPO thymopoietin
TOP2A topoisomerase (DNA) II alpha 170kDa
TP53 tumor protein p53
TPX2 TPX2, microtubule-associated
WIF1 WNT inhibitory factor 1