BRD-K31238592_-666_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

224 genes differentially expressed following the BRD-K31238592_-666_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
AREG amphiregulin
ASPH aspartate beta-hydroxylase
ASS1 argininosuccinate synthase 1
BEX4 brain expressed, X-linked 4
BIK BCL2-interacting killer (apoptosis-inducing)
CLU clusterin
CSTA cystatin A (stefin A)
DDIT4 DNA-damage-inducible transcript 4
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EML3 echinoderm microtubule associated protein like 3
F13A1 coagulation factor XIII, A1 polypeptide
FCGBP Fc fragment of IgG binding protein
FOSL2 FOS-like antigen 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GCLC glutamate-cysteine ligase, catalytic subunit
GPX2 glutathione peroxidase 2
GRB7 growth factor receptor-bound protein 7
GSN gelsolin
GULP1 GULP, engulfment adaptor PTB domain containing 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
JAG1 jagged 1
KDM5D lysine (K)-specific demethylase 5D
KRT18 keratin 18, type I
KRT19 keratin 19, type I
MAN2B1 mannosidase, alpha, class 2B, member 1
MAOA monoamine oxidase A
MAP1B microtubule-associated protein 1B
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MMP7 matrix metallopeptidase 7
MPZL2 myelin protein zero-like 2
MVP major vault protein
NDRG1 N-myc downstream regulated 1
NLGN4X neuroligin 4, X-linked
OBSL1 obscurin-like 1
PAM peptidylglycine alpha-amidating monooxygenase
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PLTP phospholipid transfer protein
PPIC peptidylprolyl isomerase C (cyclophilin C)
PRNP prion protein
PSAP prosaposin
PYGL phosphorylase, glycogen, liver
RAB13 RAB13, member RAS oncogene family
RHOB ras homolog family member B
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SPON2 spondin 2, extracellular matrix protein
TGFB1 transforming growth factor, beta 1
TRIM2 tripartite motif containing 2
UBE2L6 ubiquitin-conjugating enzyme E2L 6
VLDLR very low density lipoprotein receptor
YBX3 Y box binding protein 3
YPEL5 yippee-like 5 (Drosophila)

decreased expression

Symbol Name
ACSL3 acyl-CoA synthetase long-chain family member 3
APITD1 apoptosis-inducing, TAF9-like domain 1
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1
ARMCX2 armadillo repeat containing, X-linked 2
ASF1B anti-silencing function 1B histone chaperone
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATAD2 ATPase family, AAA domain containing 2
AURKA aurora kinase A
AURKB aurora kinase B
BIRC5 baculoviral IAP repeat containing 5
BLM Bloom syndrome, RecQ helicase-like
BRCA1 breast cancer 1, early onset
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C6ORF62 chromosome 6 open reading frame 62
CCNA2 cyclin A2
CCNB2 cyclin B2
CCNF cyclin F
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CDC7 cell division cycle 7
CDCA3 cell division cycle associated 3
CDCA8 cell division cycle associated 8
CDK1 cyclin-dependent kinase 1
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CDKN3 cyclin-dependent kinase inhibitor 3
CDT1 chromatin licensing and DNA replication factor 1
CENPA centromere protein A
CENPF centromere protein F, 350/400kDa
CENPM centromere protein M
CENPN centromere protein N
CENPU centromere protein U
CEP55 centrosomal protein 55kDa
CHEK2 checkpoint kinase 2
CIT citron rho-interacting serine/threonine kinase
CKAP2 cytoskeleton associated protein 2
CKS1B CDC28 protein kinase regulatory subunit 1B
CKS2 CDC28 protein kinase regulatory subunit 2
CXCL12 chemokine (C-X-C motif) ligand 12
DBF4 DBF4 zinc finger
DCK deoxycytidine kinase
DEPDC1 DEP domain containing 1
DHFR dihydrofolate reductase
DLEU1 deleted in lymphocytic leukemia 1 (non-protein coding)
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9
DONSON downstream neighbor of SON
DSCC1 DNA replication and sister chromatid cohesion 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUT deoxyuridine triphosphatase
E2F8 E2F transcription factor 8
EBP emopamil binding protein (sterol isomerase)
ERBB4 erb-b2 receptor tyrosine kinase 4
ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae)
EXO1 exonuclease 1
FAM64A family with sequence similarity 64, member A
FANCA Fanconi anemia, complementation group A
FANCI Fanconi anemia, complementation group I
FBXO5 F-box protein 5
FEN1 flap structure-specific endonuclease 1
FGFR3 fibroblast growth factor receptor 3
FOXM1 forkhead box M1
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GTSE1 G-2 and S-phase expressed 1
H2AFX H2A histone family, member X
HAT1 histone acetyltransferase 1
HIST1H4C histone cluster 1, H4c
HJURP Holliday junction recognition protein
HMGB1 high mobility group box 1
HMGB2 high mobility group box 2
HMMR hyaluronan-mediated motility receptor (RHAMM)
ICMT isoprenylcysteine carboxyl methyltransferase
KIAA0101 KIAA0101
KIF11 kinesin family member 11
KIF14 kinesin family member 14
KIF15 kinesin family member 15
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
KIF23 kinesin family member 23
KIF2C kinesin family member 2C
KIF4A kinesin family member 4A
KNTC1 kinetochore associated 1
LIG1 ligase I, DNA, ATP-dependent
LMNB1 lamin B1
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MAGT1 magnesium transporter 1
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM7 minichromosome maintenance complex component 7
MKI67 marker of proliferation Ki-67
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NCAPG non-SMC condensin I complex, subunit G
NCAPG2 non-SMC condensin II complex, subunit G2
NCAPH non-SMC condensin I complex, subunit H
NDC80 NDC80 kinetochore complex component
NEK2 NIMA-related kinase 2
NPR3 natriuretic peptide receptor 3
NREP neuronal regeneration related protein
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1
NUDT1 nudix (nucleoside diphosphate linked moiety X)-type motif 1
NUP62 nucleoporin 62kDa
OIP5 Opa interacting protein 5
PBK PDZ binding kinase
PLK1 polo-like kinase 1
PLK4 polo-like kinase 4
POLA2 polymerase (DNA directed), alpha 2, accessory subunit
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRC1 protein regulator of cytokinesis 1
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PSMC3IP PSMC3 interacting protein
PSPH phosphoserine phosphatase
PSRC1 proline/serine-rich coiled-coil 1
PTTG1 pituitary tumor-transforming 1
RACGAP1 Rac GTPase activating protein 1
RAD51 RAD51 recombinase
RAD51AP1 RAD51 associated protein 1
RAD51C RAD51 paralog C
RFC2 replication factor C (activator 1) 2, 40kDa
RFC3 replication factor C (activator 1) 3, 38kDa
RFC4 replication factor C (activator 1) 4, 37kDa
RFC5 replication factor C (activator 1) 5, 36.5kDa
RMI1 RecQ mediated genome instability 1
RNASEH2A ribonuclease H2, subunit A
RPA3 replication protein A3, 14kDa
RRM1 ribonucleotide reductase M1
SEPHS1 selenophosphate synthetase 1
SHCBP1 SHC SH2-domain binding protein 1
SKA1 spindle and kinetochore associated complex subunit 1
SLC2A4RG SLC2A4 regulator
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4
SMC1A structural maintenance of chromosomes 1A
SMC2 structural maintenance of chromosomes 2
SMC4 structural maintenance of chromosomes 4
SPAG5 sperm associated antigen 5
SPC25 SPC25, NDC80 kinetochore complex component
SPDL1 spindle apparatus coiled-coil protein 1
STIL SCL/TAL1 interrupting locus
STMN1 stathmin 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACC3 transforming, acidic coiled-coil containing protein 3
TAF5 TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 100kDa
TK1 thymidine kinase 1, soluble
TMEM194A transmembrane protein 194A
TMPO thymopoietin
TOP2A topoisomerase (DNA) II alpha 170kDa
TPX2 TPX2, microtubule-associated
TRIP13 thyroid hormone receptor interactor 13
TROAP trophinin associated protein
TTK TTK protein kinase
TUBB tubulin, beta class I
TYMS thymidylate synthetase
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S
USP1 ubiquitin specific peptidase 1
VRK1 vaccinia related kinase 1
WHSC1 Wolf-Hirschhorn syndrome candidate 1
ZWINT ZW10 interacting kinetochore protein