BRD-K30849099_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

90 genes differentially expressed following the BRD-K30849099_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ANKRD10 ankyrin repeat domain 10
ANXA4 annexin A4
ASCL1 achaete-scute family bHLH transcription factor 1
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
BEX1 brain expressed, X-linked 1
BTG2 BTG family, member 2
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2
CAV1 caveolin 1, caveolae protein, 22kDa
CCND2 cyclin D2
CD24 CD24 molecule
CD9 CD9 molecule
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
COL4A5 collagen, type IV, alpha 5
CPB1 carboxypeptidase B1 (tissue)
CPE carboxypeptidase E
DEGS1 delta(4)-desaturase, sphingolipid 1
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
EDN1 endothelin 1
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
EXT1 exostosin glycosyltransferase 1
FGFR2 fibroblast growth factor receptor 2
GSPT2 G1 to S phase transition 2
HDAC9 histone deacetylase 9
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6
HSPA8 heat shock 70kDa protein 8
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
JUN jun proto-oncogene
LEFTY1 left-right determination factor 1
MMP12 matrix metallopeptidase 12
MTSS1 metastasis suppressor 1
NPTX2 neuronal pentraxin II
NT5E 5'-nucleotidase, ecto (CD73)
PGK1 phosphoglycerate kinase 1
PID1 phosphotyrosine interaction domain containing 1
PLEKHM1 pleckstrin homology domain containing, family M (with RUN domain) member 1
PNMAL1 paraneoplastic Ma antigen family-like 1
PRSS2 protease, serine, 2 (trypsin 2)
PRUNE2 prune homolog 2 (Drosophila)
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RND3 Rho family GTPase 3
SPINK1 serine peptidase inhibitor, Kazal type 1
SST somatostatin
TFF3 trefoil factor 3 (intestinal)
TMEM158 transmembrane protein 158 (gene/pseudogene)
TPGS2 tubulin polyglutamylase complex subunit 2
TUFT1 tuftelin 1
UGT2B17 UDP glucuronosyltransferase 2 family, polypeptide B17
VEGFA vascular endothelial growth factor A
WBP5 WW domain binding protein 5

decreased expression

Symbol Name
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
APOD apolipoprotein D
BBOX1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
BHLHE41 basic helix-loop-helix family, member e41
CCL21 chemokine (C-C motif) ligand 21
CHPT1 choline phosphotransferase 1
CLDN10 claudin 10
CSTA cystatin A (stefin A)
CXCL5 chemokine (C-X-C motif) ligand 5
EVL Enah/Vasp-like
FABP7 fatty acid binding protein 7, brain
GADD45B growth arrest and DNA-damage-inducible, beta
GRWD1 glutamate-rich WD repeat containing 1
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
KRT7 keratin 7, type II
KYNU kynureninase
LAMC1 laminin, gamma 1 (formerly LAMB2)
LOX lysyl oxidase
LTF lactotransferrin
MAGEA12 melanoma antigen family A12
MAGEA6 melanoma antigen family A6
MREG melanoregulin
NFIB nuclear factor I/B
NQO1 NAD(P)H dehydrogenase, quinone 1
PRKCD protein kinase C, delta
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SOX11 SRY (sex determining region Y)-box 11
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)