BRD-K30849099_-666_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

102 genes differentially expressed following the BRD-K30849099_-666_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase
ARL4C ADP-ribosylation factor-like 4C
CAPN2 calpain 2, (m/II) large subunit
CD44 CD44 molecule (Indian blood group)
CYTIP cytohesin 1 interacting protein
DKK3 dickkopf WNT signaling pathway inhibitor 3
DLK1 delta-like 1 homolog (Drosophila)
FOSL1 FOS-like antigen 1
FST follistatin
FTH1 ferritin, heavy polypeptide 1
GADD45A growth arrest and DNA-damage-inducible, alpha
H2BFS H2B histone family, member S (pseudogene)
H3F3B H3 histone, family 3B (H3.3B)
HIC2 hypermethylated in cancer 2
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BC histone cluster 1, H2bc
HIST1H2BD histone cluster 1, H2bd
HIST1H2BE histone cluster 1, H2be
HIST1H2BF histone cluster 1, H2bf
HIST1H2BG histone cluster 1, H2bg
HIST1H2BH histone cluster 1, H2bh
HIST2H2BE histone cluster 2, H2be
HOXB2 homeobox B2
HOXB6 homeobox B6
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IDO1 indoleamine 2,3-dioxygenase 1
MMP12 matrix metallopeptidase 12
MXRA7 matrix-remodelling associated 7
S100A12 S100 calcium binding protein A12
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SNAI2 snail family zinc finger 2
TIMP1 TIMP metallopeptidase inhibitor 1
TPM1 tropomyosin 1 (alpha)
TUBB2A tubulin, beta 2A class IIa
TUBB2B tubulin, beta 2B class IIb

decreased expression

Symbol Name
AGR2 anterior gradient 2
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATAD2 ATPase family, AAA domain containing 2
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
B3GNT1
CA12 carbonic anhydrase XII
CDK1 cyclin-dependent kinase 1
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CENPA centromere protein A
CHPT1 choline phosphotransferase 1
CXCL12 chemokine (C-X-C motif) ligand 12
DCK deoxycytidine kinase
DCN decorin
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
EMP2 epithelial membrane protein 2
ERBB3 erb-b2 receptor tyrosine kinase 3
FXYD3 FXYD domain containing ion transport regulator 3
GADD45B growth arrest and DNA-damage-inducible, beta
GATA3 GATA binding protein 3
GLS glutaminase
IGFBP4 insulin-like growth factor binding protein 4
KIAA0101 KIAA0101
KRT7 keratin 7, type II
LUM lumican
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MELK maternal embryonic leucine zipper kinase
METTL7A methyltransferase like 7A
MGP matrix Gla protein
MKI67 marker of proliferation Ki-67
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MUC1 mucin 1, cell surface associated
NET1 neuroepithelial cell transforming 1
NFIB nuclear factor I/B
NPY1R neuropeptide Y receptor Y1
NR2F2 nuclear receptor subfamily 2, group F, member 2
OLFML3 olfactomedin-like 3
PDGFA platelet-derived growth factor alpha polypeptide
PPP1R1A protein phosphatase 1, regulatory (inhibitor) subunit 1A
PRC1 protein regulator of cytokinesis 1
PRKCD protein kinase C, delta
PTGES prostaglandin E synthase
RACGAP1 Rac GTPase activating protein 1
RRM2 ribonucleotide reductase M2
SPDEF SAM pointed domain containing ETS transcription factor
SYBU syntabulin (syntaxin-interacting)
TACSTD2 tumor-associated calcium signal transducer 2
TFF1 trefoil factor 1
TFPI2 tissue factor pathway inhibitor 2
TMEM135 transmembrane protein 135
TOMM70A translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae)
TOP2A topoisomerase (DNA) II alpha 170kDa
TPD52L1 tumor protein D52-like 1
TPX2 TPX2, microtubule-associated
TSPYL5 TSPY-like 5
TUSC3 tumor suppressor candidate 3
UBE2A ubiquitin-conjugating enzyme E2A
UBE2C ubiquitin-conjugating enzyme E2C
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VCAM1 vascular cell adhesion molecule 1
WFDC2 WAP four-disulfide core domain 2
XBP1 X-box binding protein 1