BRD-K30836161_NCGC00185094-01_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

133 genes differentially expressed following the BRD-K30836161_NCGC00185094-01_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5
ANXA10 annexin A10
ARMCX1 armadillo repeat containing, X-linked 1
ASPN asporin
BEX4 brain expressed, X-linked 4
BLNK B-cell linker
BTG2 BTG family, member 2
C3ORF14 chromosome 3 open reading frame 14
CADM1 cell adhesion molecule 1
CCP110 centriolar coiled coil protein 110kDa
CD44 CD44 molecule (Indian blood group)
CLEC2B C-type lectin domain family 2, member B
CLU clusterin
COL11A1 collagen, type XI, alpha 1
COL6A1 collagen, type VI, alpha 1
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DPT dermatopontin
EMX2 empty spiracles homeobox 2
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
EREG epiregulin
ESR1 estrogen receptor 1
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
F13A1 coagulation factor XIII, A1 polypeptide
FAM129A family with sequence similarity 129, member A
FAM3C family with sequence similarity 3, member C
FGFR2 fibroblast growth factor receptor 2
FGL2 fibrinogen-like 2
FRY furry homolog (Drosophila)
FRZB frizzled-related protein
GAS6 growth arrest-specific 6
GPNMB glycoprotein (transmembrane) nmb
GUSBP3 glucuronidase, beta pseudogene 3
HIST2H2BE histone cluster 2, H2be
IER5 immediate early response 5
IL6 interleukin 6
KCTD12 potassium channel tetramerization domain containing 12
LEF1 lymphoid enhancer-binding factor 1
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MBP myelin basic protein
MEF2C myocyte enhancer factor 2C
MMP13 matrix metallopeptidase 13
MPPED2 metallophosphoesterase domain containing 2
MXRA5 matrix-remodelling associated 5
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NPRL2 nitrogen permease regulator-like 2 (S. cerevisiae)
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa
PDP1 pyruvate dehyrogenase phosphatase catalytic subunit 1
PEA15 phosphoprotein enriched in astrocytes 15
PID1 phosphotyrosine interaction domain containing 1
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PTGDS prostaglandin D2 synthase 21kDa (brain)
RAB11FIP2 RAB11 family interacting protein 2 (class I)
RAB38 RAB38, member RAS oncogene family
RGCC regulator of cell cycle
RIPK4 receptor-interacting serine-threonine kinase 4
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5
SNAI2 snail family zinc finger 2
SOX17 SRY (sex determining region Y)-box 17
STC1 stanniocalcin 1
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TIMP3 TIMP metallopeptidase inhibitor 3
TNFAIP8 tumor necrosis factor, alpha-induced protein 8
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TWIST1 twist family bHLH transcription factor 1
TXNIP thioredoxin interacting protein
WASF1 WAS protein family, member 1
WT1 Wilms tumor 1
XIST X inactive specific transcript (non-protein coding)
ZFPM2 zinc finger protein, FOG family member 2

decreased expression

Symbol Name
ACSF2 acyl-CoA synthetase family member 2
ACSL1 acyl-CoA synthetase long-chain family member 1
ACTN1 actinin, alpha 1
ADI1 acireductone dioxygenase 1
AFP alpha-fetoprotein
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AKAP12 A kinase (PRKA) anchor protein 12
AMDHD2 amidohydrolase domain containing 2
ANXA2 annexin A2
C8ORF4 chromosome 8 open reading frame 4
CASP7 caspase 7, apoptosis-related cysteine peptidase
CDC25B cell division cycle 25B
CDCA4 cell division cycle associated 4
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CHMP4A charged multivesicular body protein 4A
COL9A3 collagen, type IX, alpha 3
CRLF1 cytokine receptor-like factor 1
CSE1L CSE1 chromosome segregation 1-like (yeast)
CTSC cathepsin C
CTTN cortactin
DHRS11 dehydrogenase/reductase (SDR family) member 11
EHBP1 EH domain binding protein 1
GDI2 GDP dissociation inhibitor 2
GMDS GDP-mannose 4,6-dehydratase
GSTT1 glutathione S-transferase theta 1
H2AFZ H2A histone family, member Z
HSPA8 heat shock 70kDa protein 8
IARS isoleucyl-tRNA synthetase
IFRD2 interferon-related developmental regulator 2
IGL immunoglobulin lambda locus
IRAK1 interleukin-1 receptor-associated kinase 1
ITGA6 integrin, alpha 6
KIF5B kinesin family member 5B
KPNB1 karyopherin (importin) beta 1
KRT14 keratin 14, type I
LANCL1 LanC lantibiotic synthetase component C-like 1 (bacterial)
LYZ lysozyme
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MAPK13 mitogen-activated protein kinase 13
MCAM melanoma cell adhesion molecule
MDK midkine (neurite growth-promoting factor 2)
NME4 NME/NM23 nucleoside diphosphate kinase 4
PAM peptidylglycine alpha-amidating monooxygenase
PCNA proliferating cell nuclear antigen
PHB prohibitin
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma
PLK1 polo-like kinase 1
PNKP polynucleotide kinase 3'-phosphatase
PRMT1 protein arginine methyltransferase 1
PTPRK protein tyrosine phosphatase, receptor type, K
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SNX11 sorting nexin 11
SOX9 SRY (sex determining region Y)-box 9
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
SYNM synemin, intermediate filament protein
TF transferrin
TM4SF1 transmembrane 4 L six family member 1
TRAPPC3 trafficking protein particle complex 3
TRIM14 tripartite motif containing 14
XPO7 exportin 7