BRD-K30240666_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

96 genes differentially expressed following the BRD-K30240666_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACPP acid phosphatase, prostate
ACSL3 acyl-CoA synthetase long-chain family member 3
ADAM10 ADAM metallopeptidase domain 10
APOD apolipoprotein D
ARHGAP29 Rho GTPase activating protein 29
CAST calpastatin
CD24 CD24 molecule
CLIC4 chloride intracellular channel 4
CYB5R2 cytochrome b5 reductase 2
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
DHRS2 dehydrogenase/reductase (SDR family) member 2
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FDPS farnesyl diphosphate synthase
GPNMB glycoprotein (transmembrane) nmb
GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like)
GULP1 GULP, engulfment adaptor PTB domain containing 1
GUSBP3 glucuronidase, beta pseudogene 3
HBB hemoglobin, beta
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPB8 heat shock 22kDa protein 8
IDI1 isopentenyl-diphosphate delta isomerase 1
IFI44L interferon-induced protein 44-like
IKZF1 IKAROS family zinc finger 1 (Ikaros)
KIAA1598
KLK10 kallikrein-related peptidase 10
KLK11 kallikrein-related peptidase 11
KLK5 kallikrein-related peptidase 5
KLK6 kallikrein-related peptidase 6
KLK8 kallikrein-related peptidase 8
LPAR6 lysophosphatidic acid receptor 6
MAP7 microtubule-associated protein 7
MFSD10 major facilitator superfamily domain containing 10
MLPH melanophilin
MSMB microseminoprotein, beta-
MSMO1 methylsterol monooxygenase 1
MUC16 mucin 16, cell surface associated
OPN3 opsin 3
PAEP progestagen-associated endometrial protein
QPCT glutaminyl-peptide cyclotransferase
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SLC16A6 solute carrier family 16, member 6
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SQLE squalene epoxidase
SST somatostatin
ST6GALNAC5 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
TBX3 T-box 3
TFPI2 tissue factor pathway inhibitor 2
TRIB3 tribbles pseudokinase 3
TXNIP thioredoxin interacting protein
VGLL1 vestigial-like family member 1
VLDLR very low density lipoprotein receptor

decreased expression

Symbol Name
ABAT 4-aminobutyrate aminotransferase
ACSL5 acyl-CoA synthetase long-chain family member 5
AKR1C3 aldo-keto reductase family 1, member C3
CA2 carbonic anhydrase II
CLEC2B C-type lectin domain family 2, member B
CLTB clathrin, light chain B
CMAHP cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene
EGR3 early growth response 3
F12 coagulation factor XII (Hageman factor)
FABP1 fatty acid binding protein 1, liver
FCGBP Fc fragment of IgG binding protein
GRIA2 glutamate receptor, ionotropic, AMPA 2
HIGD1A HIG1 hypoxia inducible domain family, member 1A
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
JAG1 jagged 1
KIF5C kinesin family member 5C
KRT20 keratin 20, type I
LGALS4 lectin, galactoside-binding, soluble, 4
NREP neuronal regeneration related protein
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
PCOLCE2 procollagen C-endopeptidase enhancer 2
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PODXL podocalyxin-like
RAD23B RAD23 homolog B (S. cerevisiae)
RNF138 ring finger protein 138, E3 ubiquitin protein ligase
SEPP1 selenoprotein P, plasma, 1
SOX4 SRY (sex determining region Y)-box 4
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TGFB1 transforming growth factor, beta 1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TLR4 toll-like receptor 4
TPM1 tropomyosin 1 (alpha)
TXNDC9 thioredoxin domain containing 9
ZEB1 zinc finger E-box binding homeobox 1