BRD-K29983336_rondual-kinase-inhibitor_MCF7_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

65 genes differentially expressed following the BRD-K29983336_rondual-kinase-inhibitor_MCF7_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACKR3 atypical chemokine receptor 3
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
CD93 CD93 molecule
CENPE centromere protein E, 312kDa
CLDN3 claudin 3
CLIC3 chloride intracellular channel 3
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL11 chemokine (C-X-C motif) ligand 11
CXCL9 chemokine (C-X-C motif) ligand 9
DDIT4 DNA-damage-inducible transcript 4
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1
EXOSC4 exosome component 4
GBP1 guanylate binding protein 1, interferon-inducible
HILPDA hypoxia inducible lipid droplet-associated
IDO1 indoleamine 2,3-dioxygenase 1
IFITM1 interferon induced transmembrane protein 1
ISOC1 isochorismatase domain containing 1
KANK1 KN motif and ankyrin repeat domains 1
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
LAMP5 lysosomal-associated membrane protein family, member 5
LCN2 lipocalin 2
LMO3 LIM domain only 3 (rhombotin-like 2)
MAP7 microtubule-associated protein 7
MFAP5 microfibrillar associated protein 5
MT1E metallothionein 1E
MT1HL1 metallothionein 1H-like 1
MT1X metallothionein 1X
NEBL nebulette
OXA1L oxidase (cytochrome c) assembly 1-like
PLIN2 perilipin 2
RGS5 regulator of G-protein signaling 5
RHOBTB3 Rho-related BTB domain containing 3
SASH1 SAM and SH3 domain containing 1
SEC14L1 SEC14-like 1 (S. cerevisiae)
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SMAD3 SMAD family member 3
SPARCL1 SPARC-like 1 (hevin)
STAT1 signal transducer and activator of transcription 1, 91kDa
STC1 stanniocalcin 1
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
VWF von Willebrand factor
WARS tryptophanyl-tRNA synthetase
XYLT1 xylosyltransferase I
ZFP36L2 ZFP36 ring finger protein-like 2
ZNF318 zinc finger protein 318

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ARG1 arginase 1
COL8A2 collagen, type VIII, alpha 2
CTSH cathepsin H
GATA3 GATA binding protein 3
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GRWD1 glutamate-rich WD repeat containing 1
HAL histidine ammonia-lyase
JAG1 jagged 1
MFAP4 microfibrillar-associated protein 4
MREG melanoregulin
PMP22 peripheral myelin protein 22
PSD3 pleckstrin and Sec7 domain containing 3
PTGDS prostaglandin D2 synthase 21kDa (brain)
SDC4 syndecan 4
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPINK1 serine peptidase inhibitor, Kazal type 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)