BRD-K29983336_rondual-kinase-inhibitor_HCC515_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

72 genes differentially expressed following the BRD-K29983336_rondual-kinase-inhibitor_HCC515_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADO 2-aminoethanethiol (cysteamine) dioxygenase
ALOX5AP arachidonate 5-lipoxygenase-activating protein
AREG amphiregulin
BEX1 brain expressed, X-linked 1
C7 complement component 7
CLDN18 claudin 18
CST3 cystatin C
CSTA cystatin A (stefin A)
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CYR61 cysteine-rich, angiogenic inducer, 61
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked
DES desmin
EGR1 early growth response 1
EGR2 early growth response 2
EPN2 epsin 2
FHL1 four and a half LIM domains 1
FUT4 fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)
GEM GTP binding protein overexpressed in skeletal muscle
HBEGF heparin-binding EGF-like growth factor
HSPB8 heat shock 22kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
LTF lactotransferrin
LUM lumican
LYZ lysozyme
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAOB monoamine oxidase B
MLPH melanophilin
MYBPC1 myosin binding protein C, slow type
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PDLIM3 PDZ and LIM domain 3
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PROM1 prominin 1
S100A9 S100 calcium binding protein A9
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SGK1 serum/glucocorticoid regulated kinase 1
SPP1 secreted phosphoprotein 1
SPRY2 sprouty homolog 2 (Drosophila)
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TFF3 trefoil factor 3 (intestinal)
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AHNAK2 AHNAK nucleoprotein 2
ALDOA aldolase A, fructose-bisphosphate
CADM1 cell adhesion molecule 1
CAV1 caveolin 1, caveolae protein, 22kDa
CDC20 cell division cycle 20
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CLIC3 chloride intracellular channel 3
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
FST follistatin
GPX3 glutathione peroxidase 3
HILPDA hypoxia inducible lipid droplet-associated
IFITM1 interferon induced transmembrane protein 1
IGHM immunoglobulin heavy constant mu
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
ITGB1BP1 integrin beta 1 binding protein 1
JUP junction plakoglobin
KDM5D lysine (K)-specific demethylase 5D
MAL mal, T-cell differentiation protein
NR1H2 nuclear receptor subfamily 1, group H, member 2
PLAGL1 pleiomorphic adenoma gene-like 1
PRAME preferentially expressed antigen in melanoma
PRKCI protein kinase C, iota
RPS4Y1 ribosomal protein S4, Y-linked 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
STAT1 signal transducer and activator of transcription 1, 91kDa
TGFBI transforming growth factor, beta-induced, 68kDa
TUBB3 tubulin, beta 3 class III
UGCG UDP-glucose ceramide glucosyltransferase