BRD-K29983336_rondual-kinase-inhibitor_HA1E_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

76 genes differentially expressed following the BRD-K29983336_rondual-kinase-inhibitor_HA1E_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
CCL19 chemokine (C-C motif) ligand 19
COL11A1 collagen, type XI, alpha 1
CP ceruloplasmin (ferroxidase)
DEGS1 delta(4)-desaturase, sphingolipid 1
DUSP1 dual specificity phosphatase 1
F5 coagulation factor V (proaccelerin, labile factor)
GOLGA8B golgin A8 family, member B
GPR137B G protein-coupled receptor 137B
HLA-DRA major histocompatibility complex, class II, DR alpha
HP haptoglobin
KIAA1598
MCL1 myeloid cell leukemia 1
NNMT nicotinamide N-methyltransferase
PDE10A phosphodiesterase 10A
PON3 paraoxonase 3
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RGCC regulator of cell cycle
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SPRED2 sprouty-related, EVH1 domain containing 2
STK26 serine/threonine protein kinase 26
TM9SF3 transmembrane 9 superfamily member 3
TRIM2 tripartite motif containing 2
TUBB2A tubulin, beta 2A class IIa
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae)

decreased expression

Symbol Name
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AKR1C3 aldo-keto reductase family 1, member C3
ARMCX1 armadillo repeat containing, X-linked 1
ATP1A2 ATPase, Na+/K+ transporting, alpha 2 polypeptide
C2CD5 C2 calcium-dependent domain containing 5
CA12 carbonic anhydrase XII
CALB1 calbindin 1, 28kDa
CCND2 cyclin D2
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCL12 chemokine (C-X-C motif) ligand 12
DLK1 delta-like 1 homolog (Drosophila)
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6
FABP7 fatty acid binding protein 7, brain
FXYD2 FXYD domain containing ion transport regulator 2
GALC galactosylceramidase
GATA3 GATA binding protein 3
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GPX3 glutathione peroxidase 3
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
HK2 hexokinase 2
HSDL2 hydroxysteroid dehydrogenase like 2
IFRD1 interferon-related developmental regulator 1
JAM3 junctional adhesion molecule 3
JUN jun proto-oncogene
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
LCN2 lipocalin 2
MAL mal, T-cell differentiation protein
MYBPC1 myosin binding protein C, slow type
NPTX2 neuronal pentraxin II
NRCAM neuronal cell adhesion molecule
NREP neuronal regeneration related protein
P3H2 prolyl 3-hydroxylase 2
PIP5K1B phosphatidylinositol-4-phosphate 5-kinase, type I, beta
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PRSS2 protease, serine, 2 (trypsin 2)
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
RHOBTB3 Rho-related BTB domain containing 3
S100P S100 calcium binding protein P
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
SPINT2 serine peptidase inhibitor, Kunitz type, 2
TACSTD2 tumor-associated calcium signal transducer 2
TLK2 tousled-like kinase 2
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TPD52L1 tumor protein D52-like 1
VCAM1 vascular cell adhesion molecule 1